Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase

Granulomatous inflammation causes severe tissue damage in mycobacterial infection while redox status was reported to be crucial in the granulomatous inflammation. Here, we used a NADPH oxidase 2 (NOX2)-deficient mice (Ncf1-/-) to investigate the role of leukocyte-produced reactive oxygen species (RO...

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Veröffentlicht in:	PloS one 2017-12, Vol.12 (12), p.e0189453-e0189453
Hauptverfasser:	Chao, Wen-Cheng, Yen, Chia-Liang, Hsieh, Cheng-Yuan, Huang, Ya-Fang, Tseng, Yau-Lin, Nigrovic, Peter Andrija, Shieh, Chi-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Biology and Life Sciences Body weight Body weight loss Chemokines Clinical medicine CYBB protein Cytokines Defects Diabetes Elastase Granulomas Hospitals Immunology Infections Infectious diseases Inflammasomes Inflammation Interleukin 1 Interleukin 1 receptors Laboratory animals Leukocytes Leukocytes (neutrophilic) Ligands Lungs Macrophages Medical research Medicine Medicine and Health Sciences Mice Mycobacterium marinum Mycobacterium tuberculosis NAD(P)H oxidase Neutrophils Oxidase Oxygen Pathogenesis Reactive oxygen species Research and Analysis Methods Rheumatology Rodents Stains & staining Studies Thoracic surgery TNF inhibitors Tuberculosis Tumor necrosis factor-TNF
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