Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer

Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69148-e69148
Hauptverfasser:	Huang, Yeqing, Jiang, Ying, Lu, Weiqi, Zhang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology c-Myb protein c-Myc protein Cancer Cell Cycle Cell division Cell growth Cell Proliferation Colon Degradation Down-Regulation - genetics Drosophila Female Hospitals Humans Insects Intracellular Signaling Peptides and Proteins - metabolism Ki-67 Antigen - metabolism Kinases MCF-7 Cells Medical research Medicine Middle Aged Myc protein Phosphorylation Polyclonal antibodies Proteasomes Protein-Serine-Threonine Kinases - metabolism Proteins Proteolysis Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myb - metabolism Regulation Rodents Signal transduction Signaling Surgery Tissues Transcription factors Tumors Ubiquitination Wnt protein
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