BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

TGF-β family members play a relevant role in tumorigenic processes, including hepatocellular carcinoma (HCC), but a specific implication of the Bone Morphogenetic Protein (BMP) subfamily is still unknown. Although originally isolated from fetal liver, little is known about BMP9, a BMP family member,...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69535-e69535
Hauptverfasser:	Herrera, Blanca, García-Álvaro, María, Cruz, Silvia, Walsh, Peter, Fernández, Margarita, Roncero, Cesáreo, Fabregat, Isabel, Sánchez, Aránzazu, Inman, Gareth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type II - chemistry Activin Receptors, Type II - metabolism Analysis Angiogenesis Apoptosis Apoptosis - drug effects Autocrine Communication - drug effects Biology Bone morphogenetic protein 9 Bone Morphogenetic Protein Receptors - metabolism Bone morphogenetic proteins Cancer Cancer cells Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Adhesion - drug effects Cell Count Cell cycle Cell growth Cell Line, Transformed Cell proliferation Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Chemical inhibitors Càncer de fetge Cèl·lules canceroses Deoxyribonucleic acid DNA Epidermal growth factor Fetuses Gene expression Gene silencing Genetic engineering Growth Differentiation Factor 2 Growth Differentiation Factors - metabolism Growth Differentiation Factors - pharmacology Health aspects Hep G2 Cells Hepatocellular carcinoma Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatology Humans Id1 protein Immunohistochemistry Kinases Ligands Liver Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Medical research Medicine Pathogenesis Phosphorylation Protein Structure, Tertiary Rodents Serum Signal Transduction - drug effects Signaling Smad Proteins - metabolism Survival factor Therapeutic applications Tissues Transforming growth factors
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