Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in pigs caused by PRRS virus (PRRSV). Although PRRSV infection-induced cell apoptosis has been established, the related viral protein is still unknown. Here, we reported that PRRSV nonstructural protein 4 (nsp4) was...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69387
Hauptverfasser:	Ma, Zhitao, Wang, Yalan, Zhao, Haiyan, Xu, Ao-Tian, Wang, Yongqiang, Tang, Jun, Feng, Wen-hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - metabolism Animals Apoptosis Apoptosis - drug effects Biocatalysis - drug effects Caspase Caspase-3 Caspases - metabolism Chlorocebus aethiops COS Cells Enzyme Activation - drug effects Enzymes Genomes HeLa Cells Hogs Humans Immunology Infection Infections Laboratory animals Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - pathology Macrophages, Alveolar - virology Mitochondria Mutation Penicillin Porcine reproductive and respiratory syndrome Porcine Reproductive and Respiratory Syndrome - pathology Porcine Reproductive and Respiratory Syndrome - virology Porcine respiratory and reproductive syndrome virus - metabolism Protease Proteases Proteins Science Sequence Deletion Serine Serine Proteases - metabolism Serine proteinase Severe acute respiratory syndrome Site-directed mutagenesis Swine Thrombin Transfection Veterinary colleges Veterinary medicine Viral proteins Viral Proteins - metabolism Viral Proteins - pharmacology Virology Viruses
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