The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis

Mycolactones are polyketide-derived lipid virulence factors made by the slow-growing human pathogen, Mycobacterium ulcerans. Three unusually large and homologous plasmid-borne genes (mlsA1: 51 kb, mlsB: 42 kb and mlsA2: 7 kb) encode the mycolactone type I polyketide synthases (PKS). The extreme size...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e70520-e70520
Hauptverfasser:	Porter, Jessica L, Tobias, Nicholas J, Pidot, Sacha J, Falgner, Steffen, Tuck, Kellie L, Vettiger, Andrea, Hong, Hui, Leadlay, Peter F, Stinear, Timothy P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biofilms Biology Biosynthesis Blotting, Western Caprolactone Cell Wall - enzymology Cell walls Confocal Confocal microscopy Electrophoresis, Polyacrylamide Gel Enzymes Fractionation Gene expression Gene Expression Regulation, Bacterial Gene Order Genes Genetic engineering Genetically modified organisms Genomics Homology Immunoblotting Immunology Macrolides - metabolism Medicine Microscopy Microscopy, Fluorescence Mycobacterium marinum Mycobacterium marinum - genetics Mycobacterium marinum - metabolism Mycobacterium ulcerans Mycobacterium ulcerans - enzymology Mycobacterium ulcerans - genetics Natural products Plasmids - genetics Polyketide Synthases - genetics Polyketide Synthases - metabolism Polymerase chain reaction Protein Stability Protein Structure, Tertiary Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism Tandem Mass Spectrometry Triketide lactone Ulcers Virulence Virulence factors
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