High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: an analysis of 715 cases from Malawi

Mortality from bacterial meningitis in African adults is significantly higher than those in better resourced settings and adjunctive therapeutic interventions such as dexamethasone and glycerol have been shown to be ineffective. We conducted a study analysing data from clinical trials of bacterial m...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69783-e69783
Hauptverfasser:	Wall, Emma C, Cartwright, Katharine, Scarborough, Matthew, Ajdukiewicz, Katherine M, Goodson, Patrick, Mwambene, James, Zijlstra, Eduard E, Gordon, Stephen B, French, Neil, Faragher, Brian, Heyderman, Robert S, Lalloo, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Adult Adults Africa South of the Sahara - epidemiology Age Analysis Anemia Antibiotics Bacteria Bacterial meningitis Cell culture Cerebrospinal fluid Clinical trials Coma Communities Data processing Dexamethasone Fatalities Female Glycerol HIV HIV antibodies HIV tests Hospitals Human immunodeficiency virus Humans Infectious diseases Leukocytes (neutrophilic) Malawi - epidemiology Male Medical research Medical schools Medicine Meningitis Meningitis, Bacterial - epidemiology Meningitis, Bacterial - mortality Middle Aged Mortality Multivariate analysis Odds Ratio Prognosis Regression analysis Risk Factors Seizures Sepsis Streptococcus infections Studies Tachycardia Teenagers Therapeutic applications White blood cell count Young Adult Youth
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