Headcase promotes cell survival and niche maintenance in the Drosophila testis
At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub ce...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-07, Vol.8 (7), p.e68026-e68026 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e68026 |
|---|---|
| container_issue | 7 |
| container_start_page | e68026 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Resende, Luís Pedro F Boyle, Monica Tran, Darrell Fellner, Thomas Jones, D Leanne |
| description | At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to identify factors involved in regulating hub maintenance, we identified headcase (hdc). Hub cells depleted for hdc undergo programmed cell death, suggesting that anti-apoptotic pathways play an important role in maintenance of the niche. Using hdc as paradigm, we describe here the first comprehensive analysis on the effects of a progressive niche reduction on the testis stem cell pool. Surprisingly, single hub cells remain capable of supporting numerous stem cells, indicating that although the size and number of niche support cells influence stem cell maintenance, the testis stem cell niche appears to be remarkably robust in the its ability to support stem cells after severe damage. |
| doi_str_mv | 10.1371/journal.pone.0068026 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1974584855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478358022</galeid><doaj_id>oai_doaj_org_article_ee5a4a8894124a6cb53c3a65c620bb3d</doaj_id><sourcerecordid>A478358022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-38d15ed1e4ecdf29aeb1c20c70c4893ccb3de5fb6f4e5bab8a55b33e12a10a823</originalsourceid><addsrcrecordid>eNqNkl1v0zAYhSMEYmPwDxBEQkJw0eLvODdI0_hYpYlJfN1ab5w3ravU7uKkgn-PS7OpQbtAuUj0-jnH9snJsueUzCkv6Lt1GDoP7XwbPM4JUZow9SA7pSVnM8UIf3j0fZI9iXFNiORaqcfZCeO6EEIXp9mXS4TaQsR824VN6DHmFts2j0O3cztoc_B17p1dYb4B53v04C3mzud9Gn3oQgzblWshT8rexafZowbaiM_G91n249PH7xeXs6vrz4uL86uZVSXrZ1zXVGJNUaCtG1YCVtQyYgtihS65tRWvUTaVagTKCioNUlacI2VACWjGz7KXB99tG6IZo4iGloWQWmgpE7E4EHWAtdl2bgPdbxPAmb-D0C0NdL2zLRpECQK0LgVlApStJLcclLQpuiqdJHm9H3cbqg3WFn3fQTsxna54tzLLsDO8IEoxmgzejAZduBlSUmbj4j5n8BiGdG5BqeJMEZHQV_-g999upJaQLuB8E9K-dm9qzkWhuUxt2Kc0v4dKT40bZ1NvGpfmE8HbiSAxPf7qlzDEaBbfvv4_e_1zyr4-YlcIbb-KoR16F3ycguIA2tSs2GFzFzIlZl_72zTMvvZmrH2SvTj-QXei257zP7vl_cI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1974584855</pqid></control><display><type>article</type><title>Headcase promotes cell survival and niche maintenance in the Drosophila testis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Resende, Luís Pedro F ; Boyle, Monica ; Tran, Darrell ; Fellner, Thomas ; Jones, D Leanne</creator><contributor>Bökel, Christian</contributor><creatorcontrib>Resende, Luís Pedro F ; Boyle, Monica ; Tran, Darrell ; Fellner, Thomas ; Jones, D Leanne ; Bökel, Christian</creatorcontrib><description>At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to identify factors involved in regulating hub maintenance, we identified headcase (hdc). Hub cells depleted for hdc undergo programmed cell death, suggesting that anti-apoptotic pathways play an important role in maintenance of the niche. Using hdc as paradigm, we describe here the first comprehensive analysis on the effects of a progressive niche reduction on the testis stem cell pool. Surprisingly, single hub cells remain capable of supporting numerous stem cells, indicating that although the size and number of niche support cells influence stem cell maintenance, the testis stem cell niche appears to be remarkably robust in the its ability to support stem cells after severe damage.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0068026</identifier><identifier>PMID: 23874487</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Apoptosis ; Apoptosis - genetics ; Biology ; Cell death ; Cell self-renewal ; Cell survival ; Cell Survival - genetics ; Cysts ; Drosophila ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Gene expression ; Genetics ; Homeostasis ; Insects ; Kinases ; Laboratories ; Maintenance ; Male ; Photoreceptors ; RNA Interference ; Somatic cells ; Sperm ; Stem Cell Niche - physiology ; Stem cells ; Stem Cells - metabolism ; Testis - metabolism ; Transcriptome ; Underpotential deposition</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e68026-e68026</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Resende et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Resende et al 2013 Resende et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-38d15ed1e4ecdf29aeb1c20c70c4893ccb3de5fb6f4e5bab8a55b33e12a10a823</citedby><cites>FETCH-LOGICAL-c692t-38d15ed1e4ecdf29aeb1c20c70c4893ccb3de5fb6f4e5bab8a55b33e12a10a823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706621/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706621/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23874487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bökel, Christian</contributor><creatorcontrib>Resende, Luís Pedro F</creatorcontrib><creatorcontrib>Boyle, Monica</creatorcontrib><creatorcontrib>Tran, Darrell</creatorcontrib><creatorcontrib>Fellner, Thomas</creatorcontrib><creatorcontrib>Jones, D Leanne</creatorcontrib><title>Headcase promotes cell survival and niche maintenance in the Drosophila testis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to identify factors involved in regulating hub maintenance, we identified headcase (hdc). Hub cells depleted for hdc undergo programmed cell death, suggesting that anti-apoptotic pathways play an important role in maintenance of the niche. Using hdc as paradigm, we describe here the first comprehensive analysis on the effects of a progressive niche reduction on the testis stem cell pool. Surprisingly, single hub cells remain capable of supporting numerous stem cells, indicating that although the size and number of niche support cells influence stem cell maintenance, the testis stem cell niche appears to be remarkably robust in the its ability to support stem cells after severe damage.</description><subject>Analysis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Biology</subject><subject>Cell death</subject><subject>Cell self-renewal</subject><subject>Cell survival</subject><subject>Cell Survival - genetics</subject><subject>Cysts</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Gene expression</subject><subject>Genetics</subject><subject>Homeostasis</subject><subject>Insects</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Maintenance</subject><subject>Male</subject><subject>Photoreceptors</subject><subject>RNA Interference</subject><subject>Somatic cells</subject><subject>Sperm</subject><subject>Stem Cell Niche - physiology</subject><subject>Stem cells</subject><subject>Stem Cells - metabolism</subject><subject>Testis - metabolism</subject><subject>Transcriptome</subject><subject>Underpotential deposition</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAYhSMEYmPwDxBEQkJw0eLvODdI0_hYpYlJfN1ab5w3ravU7uKkgn-PS7OpQbtAuUj0-jnH9snJsueUzCkv6Lt1GDoP7XwbPM4JUZow9SA7pSVnM8UIf3j0fZI9iXFNiORaqcfZCeO6EEIXp9mXS4TaQsR824VN6DHmFts2j0O3cztoc_B17p1dYb4B53v04C3mzud9Gn3oQgzblWshT8rexafZowbaiM_G91n249PH7xeXs6vrz4uL86uZVSXrZ1zXVGJNUaCtG1YCVtQyYgtihS65tRWvUTaVagTKCioNUlacI2VACWjGz7KXB99tG6IZo4iGloWQWmgpE7E4EHWAtdl2bgPdbxPAmb-D0C0NdL2zLRpECQK0LgVlApStJLcclLQpuiqdJHm9H3cbqg3WFn3fQTsxna54tzLLsDO8IEoxmgzejAZduBlSUmbj4j5n8BiGdG5BqeJMEZHQV_-g999upJaQLuB8E9K-dm9qzkWhuUxt2Kc0v4dKT40bZ1NvGpfmE8HbiSAxPf7qlzDEaBbfvv4_e_1zyr4-YlcIbb-KoR16F3ycguIA2tSs2GFzFzIlZl_72zTMvvZmrH2SvTj-QXei257zP7vl_cI</recordid><startdate>20130709</startdate><enddate>20130709</enddate><creator>Resende, Luís Pedro F</creator><creator>Boyle, Monica</creator><creator>Tran, Darrell</creator><creator>Fellner, Thomas</creator><creator>Jones, D Leanne</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130709</creationdate><title>Headcase promotes cell survival and niche maintenance in the Drosophila testis</title><author>Resende, Luís Pedro F ; Boyle, Monica ; Tran, Darrell ; Fellner, Thomas ; Jones, D Leanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-38d15ed1e4ecdf29aeb1c20c70c4893ccb3de5fb6f4e5bab8a55b33e12a10a823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Biology</topic><topic>Cell death</topic><topic>Cell self-renewal</topic><topic>Cell survival</topic><topic>Cell Survival - genetics</topic><topic>Cysts</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila - metabolism</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Gene expression</topic><topic>Genetics</topic><topic>Homeostasis</topic><topic>Insects</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Maintenance</topic><topic>Male</topic><topic>Photoreceptors</topic><topic>RNA Interference</topic><topic>Somatic cells</topic><topic>Sperm</topic><topic>Stem Cell Niche - physiology</topic><topic>Stem cells</topic><topic>Stem Cells - metabolism</topic><topic>Testis - metabolism</topic><topic>Transcriptome</topic><topic>Underpotential deposition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Resende, Luís Pedro F</creatorcontrib><creatorcontrib>Boyle, Monica</creatorcontrib><creatorcontrib>Tran, Darrell</creatorcontrib><creatorcontrib>Fellner, Thomas</creatorcontrib><creatorcontrib>Jones, D Leanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Resende, Luís Pedro F</au><au>Boyle, Monica</au><au>Tran, Darrell</au><au>Fellner, Thomas</au><au>Jones, D Leanne</au><au>Bökel, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Headcase promotes cell survival and niche maintenance in the Drosophila testis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-09</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e68026</spage><epage>e68026</epage><pages>e68026-e68026</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>At the apical tip of the Drosophila testis, germline and somatic stem cells surround a cluster of somatic cells called the hub. Hub cells produce a self-renewal factor, Unpaired (Upd), that activates the JAK-STAT pathway in adjacent stem cells to regulate stem cell behavior. Therefore, apical hub cells are a critical component of the stem cell niche in the testis. In the course of a screen to identify factors involved in regulating hub maintenance, we identified headcase (hdc). Hub cells depleted for hdc undergo programmed cell death, suggesting that anti-apoptotic pathways play an important role in maintenance of the niche. Using hdc as paradigm, we describe here the first comprehensive analysis on the effects of a progressive niche reduction on the testis stem cell pool. Surprisingly, single hub cells remain capable of supporting numerous stem cells, indicating that although the size and number of niche support cells influence stem cell maintenance, the testis stem cell niche appears to be remarkably robust in the its ability to support stem cells after severe damage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23874487</pmid><doi>10.1371/journal.pone.0068026</doi><tpages>e68026</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-07, Vol.8 (7), p.e68026-e68026 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1974584855 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animals Apoptosis Apoptosis - genetics Biology Cell death Cell self-renewal Cell survival Cell Survival - genetics Cysts Drosophila Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene expression Genetics Homeostasis Insects Kinases Laboratories Maintenance Male Photoreceptors RNA Interference Somatic cells Sperm Stem Cell Niche - physiology Stem cells Stem Cells - metabolism Testis - metabolism Transcriptome Underpotential deposition |
| title | Headcase promotes cell survival and niche maintenance in the Drosophila testis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T17%3A20%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Headcase%20promotes%20cell%20survival%20and%20niche%20maintenance%20in%20the%20Drosophila%20testis&rft.jtitle=PloS%20one&rft.au=Resende,%20Lu%C3%ADs%20Pedro%20F&rft.date=2013-07-09&rft.volume=8&rft.issue=7&rft.spage=e68026&rft.epage=e68026&rft.pages=e68026-e68026&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0068026&rft_dat=%3Cgale_plos_%3EA478358022%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1974584855&rft_id=info:pmid/23874487&rft_galeid=A478358022&rft_doaj_id=oai_doaj_org_article_ee5a4a8894124a6cb53c3a65c620bb3d&rfr_iscdi=true |