Transcription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors

The purpose of this study was to explore the role of transcription factor Ets1 in estrogen receptor α (ERα)-positive breast cancer progression. We expressed human Ets1 or empty vector in four human ERα-positive breast cancer cell lines and observed increased colony formation. Further examination of...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68815
Hauptverfasser:	Kalet, Brian T, Anglin, Sara R, Handschy, Anne, O'Donoghue, Liza E, Halsey, Charles, Chubb, Laura, Korch, Christopher, Duval, Dawn L
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Amino acids Animals Apoptosis Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer cells Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation - drug effects DNA methylation Estradiol Estradiol - metabolism Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogens Ets-1 protein Female Gene Expression Genes Growth Humans Ki-67 Antigen - metabolism Kinases Luciferase MCF-7 Cells Medicine Mice Multiprotein Complexes - metabolism Phenols Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Progesterone Protein Binding Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Protein c-ets-1 - metabolism Response Elements Rodents Sex hormones Staining Trefoil factor Tumor Burden - drug effects Tumor cell lines Tumor Stem Cell Assay Tumors
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