A blaOXA-181-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance
Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage...
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| Veröffentlicht in: | PloS one 2017-12, Vol.12 (12), p.e0189438-e0189438 |
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| creator | Nahid, Fouzia Zahra, Rabaab Sandegren, Linus |
| description | Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147. Analysis from whole genome sequencing revealed a very high sequence similarity to the previously sequenced pan-resistant K. pneumoniae isolate MS6671 from the United Arab Emirates. The two isolates are very closely related with only 46 chromosomal nucleotide differences, 14 indels and differences in plasmid content. Both carry a substantial number of plasmid-borne and chromosomally encoded resistance determinants. Interestingly, the two differences in susceptibility between the isolates could be attributed to DA48896 lacking an insertion of blaOXA-181 into the mgrB gene that results in colistin resistance in MS6671 and SNPs affecting AcrAB efflux pump expression likely to result in tigecycline resistance. These differences between the otherwise very similar isolates indicate that strong selection has occurred for resistance towards these last-resort drugs and illustrates the trajectory of resistance evolution of OXA-181-producing versions of the ST147 international risk clone. |
| doi_str_mv | 10.1371/journal.pone.0189438 |
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Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147. Analysis from whole genome sequencing revealed a very high sequence similarity to the previously sequenced pan-resistant K. pneumoniae isolate MS6671 from the United Arab Emirates. The two isolates are very closely related with only 46 chromosomal nucleotide differences, 14 indels and differences in plasmid content. Both carry a substantial number of plasmid-borne and chromosomally encoded resistance determinants. Interestingly, the two differences in susceptibility between the isolates could be attributed to DA48896 lacking an insertion of blaOXA-181 into the mgrB gene that results in colistin resistance in MS6671 and SNPs affecting AcrAB efflux pump expression likely to result in tigecycline resistance. These differences between the otherwise very similar isolates indicate that strong selection has occurred for resistance towards these last-resort drugs and illustrates the trajectory of resistance evolution of OXA-181-producing versions of the ST147 international risk clone.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0189438</identifier><identifier>PMID: 29220374</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibiotics ; Antimicrobial agents ; Biochemistry ; Biology and Life Sciences ; Chemotherapy ; Chromosomes ; Colistin ; Deoxyribonucleic acid ; DNA ; Drug resistance ; Drugs ; Efflux ; Enterobacteriaceae ; Gene sequencing ; Genes ; Genomes ; Genomics ; Hospitals ; Identification ; Insertion ; Klebsiella ; Klebsiella pneumoniae ; Laboratories ; Medicine and Health Sciences ; Next-generation sequencing ; Nucleotide sequence ; Pandemics ; Plasmids ; Research and Analysis Methods ; Single-nucleotide polymorphism ; Tigecycline</subject><ispartof>PloS one, 2017-12, Vol.12 (12), p.e0189438-e0189438</ispartof><rights>2017 Nahid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147. Analysis from whole genome sequencing revealed a very high sequence similarity to the previously sequenced pan-resistant K. pneumoniae isolate MS6671 from the United Arab Emirates. The two isolates are very closely related with only 46 chromosomal nucleotide differences, 14 indels and differences in plasmid content. Both carry a substantial number of plasmid-borne and chromosomally encoded resistance determinants. Interestingly, the two differences in susceptibility between the isolates could be attributed to DA48896 lacking an insertion of blaOXA-181 into the mgrB gene that results in colistin resistance in MS6671 and SNPs affecting AcrAB efflux pump expression likely to result in tigecycline resistance. These differences between the otherwise very similar isolates indicate that strong selection has occurred for resistance towards these last-resort drugs and illustrates the trajectory of resistance evolution of OXA-181-producing versions of the ST147 international risk clone.</description><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Chemotherapy</subject><subject>Chromosomes</subject><subject>Colistin</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Drugs</subject><subject>Efflux</subject><subject>Enterobacteriaceae</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hospitals</subject><subject>Identification</subject><subject>Insertion</subject><subject>Klebsiella</subject><subject>Klebsiella 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Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nahid, Fouzia</au><au>Zahra, Rabaab</au><au>Sandegren, Linus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A blaOXA-181-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>12</volume><issue>12</issue><spage>e0189438</spage><epage>e0189438</epage><pages>e0189438-e0189438</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147. Analysis from whole genome sequencing revealed a very high sequence similarity to the previously sequenced pan-resistant K. pneumoniae isolate MS6671 from the United Arab Emirates. The two isolates are very closely related with only 46 chromosomal nucleotide differences, 14 indels and differences in plasmid content. Both carry a substantial number of plasmid-borne and chromosomally encoded resistance determinants. Interestingly, the two differences in susceptibility between the isolates could be attributed to DA48896 lacking an insertion of blaOXA-181 into the mgrB gene that results in colistin resistance in MS6671 and SNPs affecting AcrAB efflux pump expression likely to result in tigecycline resistance. These differences between the otherwise very similar isolates indicate that strong selection has occurred for resistance towards these last-resort drugs and illustrates the trajectory of resistance evolution of OXA-181-producing versions of the ST147 international risk clone.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29220374</pmid><doi>10.1371/journal.pone.0189438</doi><orcidid>https://orcid.org/0000-0001-7382-9782</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics Antimicrobial agents Biochemistry Biology and Life Sciences Chemotherapy Chromosomes Colistin Deoxyribonucleic acid DNA Drug resistance Drugs Efflux Enterobacteriaceae Gene sequencing Genes Genomes Genomics Hospitals Identification Insertion Klebsiella Klebsiella pneumoniae Laboratories Medicine and Health Sciences Next-generation sequencing Nucleotide sequence Pandemics Plasmids Research and Analysis Methods Single-nucleotide polymorphism Tigecycline |
| title | A blaOXA-181-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance |
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