Comparison between the diagnostic validities of Xpert MTB/RIF and interferon-γ release assays for tuberculous pericarditis using pericardial tissue
This study aimed to assess the diagnostic performance of Xpert MTB/RIF for tuberculous pericarditis (TBP) using pericardial tissues. The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) a...
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| creator | Yu, Guocan Ye, Bo Chen, Da Zhong, Fangming Chen, Gang Yang, Jun Xu, Liliang Xu, Xudong |
| description | This study aimed to assess the diagnostic performance of Xpert MTB/RIF for tuberculous pericarditis (TBP) using pericardial tissues.
The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) and the Xpert MTB/RIF test were performed using peripheral blood and pericardial tissues, respectively. TBP was confirmed using pericardial histopathology and a composite reference standard (CRS). We analyzed the sensitivity, specificity, predictive value (PV), likelihood ratio (LR), and area under curve (AUC) of both assays.
Fourteen patients were confirmed as TBP, 10 as non-TBP, and 3 as probable TBP. The sensitivity, specificity, positive PV (PPV), negative PV (NPV), PLR, NLR, and AUC (95% confidence interval [CI]) of the Xpert MTB/RIF assay were 78.6% (49.2-95.3%) and 70.6% (44.0-89.7%); 92.3% (64.0-99.8%) and 100% (69.2-100%); 91.7% (61.5-99.8%) and 100% (73.5-100%); 80.0% (51.9-95.7%) and 66.7% (38.4-88.2%); 10.21 (1.52-68.49) and the PLR value was undefined with CRS as the reference; 0.23 (0.08-0.64) and 0.29(0.14-0.61); and 0.854 (0.666-0.959) and 0.853 (0.664-0.959), against histopathology and CRS, respectively. The sensitivity, specificity, PPV, NPV, PLR, NLR, and AUC values (95% CI) of T-SPOT.TB were 92.9% (66.1-99.8%) and 94.1% (71.3-99.9%); 15.4% (1.9-45.5%) and 20.0% (2.5-55.6%); 54.2% (32.8-74.5%) and 66.7% (44.7-84.4%); 66.7% (9.4-99.2%) and 66.7% (9.4-99.2%); 1.10 (0.83-1.44) and 1.18 (0.84-1.6); 0.46 (0.05-4.53) and 0.29 (0.03-2.85); and 0.541(0.340-0.733) and 0.571(0.367-0.758), against histopathology and CRS, respectively. The differences in sensitivity, PPV, and AUC of Xpert MTB/RIF and T-SPOT.TB were not statistically significant (P > 0.05), compared to those of histopathology and CRS. However, the differences in specificity and NPV of the two assays were significant (P < 0.05), compared to those of histopathology and CRS.
Xpert MTB/RIF test is a valid diagnostic technique for TBP with higher sensitivity and specificity than T-SPOT.TB. |
| doi_str_mv | 10.1371/journal.pone.0188704 |
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The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) and the Xpert MTB/RIF test were performed using peripheral blood and pericardial tissues, respectively. TBP was confirmed using pericardial histopathology and a composite reference standard (CRS). We analyzed the sensitivity, specificity, predictive value (PV), likelihood ratio (LR), and area under curve (AUC) of both assays.
Fourteen patients were confirmed as TBP, 10 as non-TBP, and 3 as probable TBP. The sensitivity, specificity, positive PV (PPV), negative PV (NPV), PLR, NLR, and AUC (95% confidence interval [CI]) of the Xpert MTB/RIF assay were 78.6% (49.2-95.3%) and 70.6% (44.0-89.7%); 92.3% (64.0-99.8%) and 100% (69.2-100%); 91.7% (61.5-99.8%) and 100% (73.5-100%); 80.0% (51.9-95.7%) and 66.7% (38.4-88.2%); 10.21 (1.52-68.49) and the PLR value was undefined with CRS as the reference; 0.23 (0.08-0.64) and 0.29(0.14-0.61); and 0.854 (0.666-0.959) and 0.853 (0.664-0.959), against histopathology and CRS, respectively. The sensitivity, specificity, PPV, NPV, PLR, NLR, and AUC values (95% CI) of T-SPOT.TB were 92.9% (66.1-99.8%) and 94.1% (71.3-99.9%); 15.4% (1.9-45.5%) and 20.0% (2.5-55.6%); 54.2% (32.8-74.5%) and 66.7% (44.7-84.4%); 66.7% (9.4-99.2%) and 66.7% (9.4-99.2%); 1.10 (0.83-1.44) and 1.18 (0.84-1.6); 0.46 (0.05-4.53) and 0.29 (0.03-2.85); and 0.541(0.340-0.733) and 0.571(0.367-0.758), against histopathology and CRS, respectively. The differences in sensitivity, PPV, and AUC of Xpert MTB/RIF and T-SPOT.TB were not statistically significant (P > 0.05), compared to those of histopathology and CRS. However, the differences in specificity and NPV of the two assays were significant (P < 0.05), compared to those of histopathology and CRS.
Xpert MTB/RIF test is a valid diagnostic technique for TBP with higher sensitivity and specificity than T-SPOT.TB.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0188704</identifier><identifier>PMID: 29211755</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenosine ; Assaying ; Biology and Life Sciences ; Confidence intervals ; Consent ; Diagnostic systems ; Histopathology ; Hospitals ; Humans ; Infections ; Interferon ; Interferon-gamma Release Tests ; Likelihood ratio ; Medical diagnosis ; Medical imaging ; Medicine and Health Sciences ; Mycobacterium tuberculosis ; Patients ; Pericarditis ; Pericarditis, Tuberculous - diagnosis ; Peripheral blood ; Sensitivity ; Sensitivity analysis ; Sensitivity and Specificity ; Statistical analysis ; Surgery ; Thoracic surgery ; Tissues ; Tuberculosis</subject><ispartof>PloS one, 2017-12, Vol.12 (12), p.e0188704-e0188704</ispartof><rights>2017 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Yu et al 2017 Yu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-1bf4bed3330a0c88a778b53c743645b4d3835f360664d287d0d3e45c7f27c683</citedby><cites>FETCH-LOGICAL-c526t-1bf4bed3330a0c88a778b53c743645b4d3835f360664d287d0d3e45c7f27c683</cites><orcidid>0000-0003-0234-1565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718425/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718425/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29211755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wilkinson, Katalin Andrea</contributor><creatorcontrib>Yu, Guocan</creatorcontrib><creatorcontrib>Ye, Bo</creatorcontrib><creatorcontrib>Chen, Da</creatorcontrib><creatorcontrib>Zhong, Fangming</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Xu, Liliang</creatorcontrib><creatorcontrib>Xu, Xudong</creatorcontrib><title>Comparison between the diagnostic validities of Xpert MTB/RIF and interferon-γ release assays for tuberculous pericarditis using pericardial tissue</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to assess the diagnostic performance of Xpert MTB/RIF for tuberculous pericarditis (TBP) using pericardial tissues.
The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) and the Xpert MTB/RIF test were performed using peripheral blood and pericardial tissues, respectively. TBP was confirmed using pericardial histopathology and a composite reference standard (CRS). We analyzed the sensitivity, specificity, predictive value (PV), likelihood ratio (LR), and area under curve (AUC) of both assays.
Fourteen patients were confirmed as TBP, 10 as non-TBP, and 3 as probable TBP. The sensitivity, specificity, positive PV (PPV), negative PV (NPV), PLR, NLR, and AUC (95% confidence interval [CI]) of the Xpert MTB/RIF assay were 78.6% (49.2-95.3%) and 70.6% (44.0-89.7%); 92.3% (64.0-99.8%) and 100% (69.2-100%); 91.7% (61.5-99.8%) and 100% (73.5-100%); 80.0% (51.9-95.7%) and 66.7% (38.4-88.2%); 10.21 (1.52-68.49) and the PLR value was undefined with CRS as the reference; 0.23 (0.08-0.64) and 0.29(0.14-0.61); and 0.854 (0.666-0.959) and 0.853 (0.664-0.959), against histopathology and CRS, respectively. The sensitivity, specificity, PPV, NPV, PLR, NLR, and AUC values (95% CI) of T-SPOT.TB were 92.9% (66.1-99.8%) and 94.1% (71.3-99.9%); 15.4% (1.9-45.5%) and 20.0% (2.5-55.6%); 54.2% (32.8-74.5%) and 66.7% (44.7-84.4%); 66.7% (9.4-99.2%) and 66.7% (9.4-99.2%); 1.10 (0.83-1.44) and 1.18 (0.84-1.6); 0.46 (0.05-4.53) and 0.29 (0.03-2.85); and 0.541(0.340-0.733) and 0.571(0.367-0.758), against histopathology and CRS, respectively. The differences in sensitivity, PPV, and AUC of Xpert MTB/RIF and T-SPOT.TB were not statistically significant (P > 0.05), compared to those of histopathology and CRS. However, the differences in specificity and NPV of the two assays were significant (P < 0.05), compared to those of histopathology and CRS.
Xpert MTB/RIF test is a valid diagnostic technique for TBP with higher sensitivity and specificity than T-SPOT.TB.</description><subject>Adenosine</subject><subject>Assaying</subject><subject>Biology and Life Sciences</subject><subject>Confidence intervals</subject><subject>Consent</subject><subject>Diagnostic systems</subject><subject>Histopathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon-gamma Release Tests</subject><subject>Likelihood ratio</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Mycobacterium tuberculosis</subject><subject>Patients</subject><subject>Pericarditis</subject><subject>Pericarditis, Tuberculous - diagnosis</subject><subject>Peripheral blood</subject><subject>Sensitivity</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Thoracic 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between the diagnostic validities of Xpert MTB/RIF and interferon-γ release assays for tuberculous pericarditis using pericardial tissue</title><author>Yu, Guocan ; Ye, Bo ; Chen, Da ; Zhong, Fangming ; Chen, Gang ; Yang, Jun ; Xu, Liliang ; Xu, Xudong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-1bf4bed3330a0c88a778b53c743645b4d3835f360664d287d0d3e45c7f27c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosine</topic><topic>Assaying</topic><topic>Biology and Life Sciences</topic><topic>Confidence intervals</topic><topic>Consent</topic><topic>Diagnostic systems</topic><topic>Histopathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interferon-gamma Release Tests</topic><topic>Likelihood ratio</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Mycobacterium tuberculosis</topic><topic>Patients</topic><topic>Pericarditis</topic><topic>Pericarditis, Tuberculous - diagnosis</topic><topic>Peripheral blood</topic><topic>Sensitivity</topic><topic>Sensitivity analysis</topic><topic>Sensitivity and Specificity</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Thoracic surgery</topic><topic>Tissues</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Guocan</creatorcontrib><creatorcontrib>Ye, Bo</creatorcontrib><creatorcontrib>Chen, Da</creatorcontrib><creatorcontrib>Zhong, Fangming</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Xu, Liliang</creatorcontrib><creatorcontrib>Xu, Xudong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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One</addtitle><date>2017-12-06</date><risdate>2017</risdate><volume>12</volume><issue>12</issue><spage>e0188704</spage><epage>e0188704</epage><pages>e0188704-e0188704</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to assess the diagnostic performance of Xpert MTB/RIF for tuberculous pericarditis (TBP) using pericardial tissues.
The study involved 30 patients admitted with suspected TBP from January-December 2016; three patients were later excluded. The interferon-γ release assay (T-SPOT.TB) and the Xpert MTB/RIF test were performed using peripheral blood and pericardial tissues, respectively. TBP was confirmed using pericardial histopathology and a composite reference standard (CRS). We analyzed the sensitivity, specificity, predictive value (PV), likelihood ratio (LR), and area under curve (AUC) of both assays.
Fourteen patients were confirmed as TBP, 10 as non-TBP, and 3 as probable TBP. The sensitivity, specificity, positive PV (PPV), negative PV (NPV), PLR, NLR, and AUC (95% confidence interval [CI]) of the Xpert MTB/RIF assay were 78.6% (49.2-95.3%) and 70.6% (44.0-89.7%); 92.3% (64.0-99.8%) and 100% (69.2-100%); 91.7% (61.5-99.8%) and 100% (73.5-100%); 80.0% (51.9-95.7%) and 66.7% (38.4-88.2%); 10.21 (1.52-68.49) and the PLR value was undefined with CRS as the reference; 0.23 (0.08-0.64) and 0.29(0.14-0.61); and 0.854 (0.666-0.959) and 0.853 (0.664-0.959), against histopathology and CRS, respectively. The sensitivity, specificity, PPV, NPV, PLR, NLR, and AUC values (95% CI) of T-SPOT.TB were 92.9% (66.1-99.8%) and 94.1% (71.3-99.9%); 15.4% (1.9-45.5%) and 20.0% (2.5-55.6%); 54.2% (32.8-74.5%) and 66.7% (44.7-84.4%); 66.7% (9.4-99.2%) and 66.7% (9.4-99.2%); 1.10 (0.83-1.44) and 1.18 (0.84-1.6); 0.46 (0.05-4.53) and 0.29 (0.03-2.85); and 0.541(0.340-0.733) and 0.571(0.367-0.758), against histopathology and CRS, respectively. The differences in sensitivity, PPV, and AUC of Xpert MTB/RIF and T-SPOT.TB were not statistically significant (P > 0.05), compared to those of histopathology and CRS. However, the differences in specificity and NPV of the two assays were significant (P < 0.05), compared to those of histopathology and CRS.
Xpert MTB/RIF test is a valid diagnostic technique for TBP with higher sensitivity and specificity than T-SPOT.TB.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29211755</pmid><doi>10.1371/journal.pone.0188704</doi><orcidid>https://orcid.org/0000-0003-0234-1565</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-12, Vol.12 (12), p.e0188704-e0188704 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1973446105 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adenosine Assaying Biology and Life Sciences Confidence intervals Consent Diagnostic systems Histopathology Hospitals Humans Infections Interferon Interferon-gamma Release Tests Likelihood ratio Medical diagnosis Medical imaging Medicine and Health Sciences Mycobacterium tuberculosis Patients Pericarditis Pericarditis, Tuberculous - diagnosis Peripheral blood Sensitivity Sensitivity analysis Sensitivity and Specificity Statistical analysis Surgery Thoracic surgery Tissues Tuberculosis |
| title | Comparison between the diagnostic validities of Xpert MTB/RIF and interferon-γ release assays for tuberculous pericarditis using pericardial tissue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T16%3A58%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20between%20the%20diagnostic%20validities%20of%20Xpert%20MTB/RIF%20and%20interferon-%CE%B3%20release%20assays%20for%20tuberculous%20pericarditis%20using%20pericardial%20tissue&rft.jtitle=PloS%20one&rft.au=Yu,%20Guocan&rft.date=2017-12-06&rft.volume=12&rft.issue=12&rft.spage=e0188704&rft.epage=e0188704&rft.pages=e0188704-e0188704&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0188704&rft_dat=%3Cproquest_plos_%3E1973446105%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1973446105&rft_id=info:pmid/29211755&rft_doaj_id=oai_doaj_org_article_e4104d34472f4edf89db5a31e29bcdec&rfr_iscdi=true |