Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats

The objective of this study was to identify the key changed subtype of T helper cells (Th cells) and their cytokines in pristane-induced arthritis (PIA) in rats. The severity of arthritis was evaluated by body weight, clinical score, the perimeter of ankle and mid-paw and histological assessment of...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188199
Hauptverfasser:	Wang, Bo, Zhao, Panpan, Zhou, Yan, Meng, Liesu, Zhu, Wenhua, Jiang, Congshan, Wang, Linyu, Cai, Yongsong, Lu, Shemin, Hou, Weikun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Ankle Arthritis Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - metabolism Autoimmune diseases Biochemistry Biology and Life Sciences Body weight Collagen Correlation analysis Cytokines Cytokines - metabolism Development and progression Disease Disease Models, Animal Enzyme-Linked Immunosorbent Assay Gene expression Genetic aspects Helper cells Hospitals Inflammation Interleukin 22 Interleukins - blood Interleukins - metabolism Joint diseases Joint surgery Laboratories Lymph nodes Lymph Nodes - metabolism Lymphocytes Lymphocytes T Medicine Medicine and Health Sciences Molecular biology mRNA Pathogenesis Pathogens Pristane Rats Real time Real-Time Polymerase Chain Reaction Receptors Rheumatism Rheumatoid arthritis Rheumatology Rodents Spleen Spleen - metabolism Synovial membrane T cells Terpenes - toxicity Th17 Cells - metabolism Western blotting
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