Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress

Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the pero...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188596
Hauptverfasser:	Sekulic-Jablanovic, Marijana, Petkovic, Vesna, Wright, Matthew B, Kucharava, Krystsina, Huerzeler, Nathan, Levano, Soledad, Brand, Yves, Leitmeyer, Katharina, Glutz, Andrea, Bausch, Alexander, Bodmer, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amyotrophic lateral sclerosis Animals Apoptosis Auditory defects Biology and Life Sciences Brain research Caspase Cochlea Detoxification Diabetes Diabetes mellitus Drug delivery Drugs Dyslipidemia Explants Fenofibrate Gene expression Genes Gentamicin Glucose metabolism Glutathione Hair cells Hearing loss Homeostasis Hospitals Immunofluorescence Kinases Lipid metabolism Lipid peroxidation Lysates Medicine and Health Sciences Metabolism Neurosciences Organ of Corti Otolaryngology Ototoxicity Oxidative stress Oxygen Parkinson's disease Peroxidation Poly(ADP-ribose) polymerase Proteins Reactive oxygen species Receptors Research and Analysis Methods Restoration Stroke Studies Toxicity Transcription factors Western blotting
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