Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice

Sepsis-induced neuroinflammation plays an important role in sepsis-related brain dysfunction. However, the molecules that are targeted during neuroinflammation resulting from sepsis-induced brain dysfunction remain unclear. Herein, we tried to investigate the expression and roles of NMDA receptor su...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188273-e0188273
Hauptverfasser:	Zhang, Shuibing, Wang, Xueqin, Ai, Sha, Ouyang, Wen, Le, Yuan, Tong, Jianbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Animal cognition Animal models Biology and Life Sciences Brain Cecum Complications and side effects Cyclic AMP response element-binding protein D-Serine Development and progression Experiments Genetic aspects Glutamic acid receptors (ionotropic) Hippocampus IL-1β Inflammation Injection Kinases Learning Lipopolysaccharides Medical research Medicine and Health Sciences Memory Methyl aspartate Mice mRNA N-Methyl-D-aspartic acid receptors Nervous system diseases Neuropathology Open-field behavior Oxidative stress Perforation Physiological aspects Polymerase chain reaction Reactive oxygen species Receptors Research and Analysis Methods Risk factors Rodents Sepsis Staining Surgery Synaptophysin Tumor necrosis factor-α
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