HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum

HIV-1 and addictive drugs, such as cocaine (COC), may act in combination to produce serious neurological complications. In the present experiments, striatal brain slices from HIV-1 transgenic (Tg) and F344 control female rats were studied. First, we examined dopamine (DA) reuptake in control, HIV-1,...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188404-e0188404
Hauptverfasser:	Javadi-Paydar, Mehrak, Roscoe, Jr, Robert F, Denton, Adam R, Mactutus, Charles F, Booze, Rosemarie M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Brain Brain research Brain slice preparation Cocaine Cocaine - pharmacology Complications Corpus Striatum - cytology Dendritic spines Dendritic Spines - drug effects Dendritic Spines - metabolism Disruption Dopamine Dopamine - metabolism Dopamine transporter Drug abuse Drug addiction Drugs Female Gene expression Health aspects HIV HIV-1 - physiology Human immunodeficiency virus Laboratory animals Medicine and Health Sciences Morphology Narcotics Neostriatum Neurological complications Neurons Neurons - drug effects Neurons - metabolism Neurosciences Neurotoxicity Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Physical Sciences Physiological aspects Proteins Rats Rats, Inbred F344 Rats, Transgenic Rodents Spine Spiny neurons
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