Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development

Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes, including cell cycle progression, transcription, signal transduction and development. Serving as the scaffold protein, cullins are crucial for the assembly of ligase complexes, which recognize and targe...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37070
Hauptverfasser:	Jiang, Baichun, Zhao, Wei, Yuan, Jupeng, Qian, Yanyan, Sun, Wenjie, Zou, Yongxin, Guo, Chenhong, Chen, Bingxi, Shao, Changshun, Gong, Yaoqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Apoptosis Base Sequence Biology Cell cycle Cell Proliferation Cullin Cullin Proteins - genetics Cullin Proteins - physiology Cyclin E Deactivation Delay Deoxyribonucleic acid DNA DNA, Complementary - genetics Drosophila Education Embryo Loss - enzymology Embryo Loss - genetics Embryogenesis Embryonic development Embryonic Development - genetics Embryonic Development - physiology Embryonic growth stage Embryos Epigenetics Exons Female Genomes Hemizygote Heterozygote Heterozygotes Humans Inactivation Insects Intellectual disabilities Laboratories Lethality Ligases Male Males Medicine Mental disorders Mental Retardation, X-Linked - embryology Mental Retardation, X-Linked - genetics Mice Mice, Inbred C57BL Mice, Knockout Mutation Nervous system Neurogenesis Null cells Placenta Placenta - abnormalities Placenta - blood supply Placenta - enzymology Pregnancy Proteins Rodents Sequence Deletion Signal processing Signal transduction Species Specificity Substrates Target recognition Transcription Transduction Ubiquitin Ubiquitin-protein ligase Vascularization X Chromosome Inactivation
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