Stiffness analysis of 3D spheroids using microtweezers

We describe a novel mechanical characterization method that has directly measured the stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a key parameter that characterizes cancerous and normal cells. Atomic force microscopy or optical tweezers have been typic...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188346-e0188346
Hauptverfasser:	Jaiswal, Devina, Cowley, Norah, Bian, Zichao, Zheng, Guoan, Claffey, Kevin P, Hoshino, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Atomic force microscopy Biology and Life Sciences Biomedical engineering Cancer Cancer cells Cellular structure Collagen Collagenase Mechanical properties Microscopy Modulus of elasticity Neural networks Physical Sciences Physiological aspects Pillars Research and analysis methods Spheroids Stiffness Tissue engineering Viscoelasticity
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