Intestinal Ralstonia pickettii augments glucose intolerance in obesity

An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0181693-e0181693
Hauptverfasser:	Udayappan, Shanthadevi D, Kovatcheva-Datchary, Petia, Bakker, Guido J, Havik, Stefan R, Herrema, Hilde, Cani, Patrice D, Bouter, Kristien E, Belzer, Clara, Witjes, Julia J, Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H, Aalvink, Steven, Dallinga-Thie, Geesje M, Heilig, Hans G H J, Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A, Hoekstra, Joost B L, Holleman, Frits, Stroes, Erik S G, Groen, Albert K, Bäckhed, Fredrik, de Vos, Willem M, Nieuwdorp, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Aged Animals Bacteria Biology and Life Sciences Deoxyribonucleic acid Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - microbiology Diet, High-Fat diet-induced obesity DNA DNA, Bacterial - analysis Endocrinology and Diabetes Endokrinologi och diabetes Endotoxins fat Feces - microbiology Female gastrointestinal-tract Glucose Glucose intolerance Glucose Intolerance - complications Glucose Intolerance - microbiology Glucose tolerance Gram-Negative Bacterial Infections - microbiology Gram-Negative Bacterial Infections - pathology gut microbiota Humans immunity Inflammation - complications Inflammation - pathology Insulin Insulin resistance Intestinal microflora Intestine Intestines - microbiology Intestines - pathology Intolerance Intra-Abdominal Fat - microbiology Intra-Abdominal Fat - pathology Laboratorium voor Microbiologie low-grade inflammation Male Medicine and Health Sciences Metabolic diseases Metabolic disorders metabolic syndrome Mice Mice, Inbred C57BL Microbiological Laboratory Microbiologie Microbiology Microbiota Microbiota (Symbiotic organisms) Obesity Obesity - complications Obesity - microbiology Pathogenesis Physical sciences Physiological aspects Ralstonia pickettii Ralstonia pickettii - physiology receptor 5 Risk factors Rodents rRNA 16S Soil bacteria Teaching hospitals VLAG WIMEK
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