Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis

Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms in the HO1 gene (...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187772-e0187772
Hauptverfasser:	Gibbons, Simon J, Grover, Madhusudan, Choi, Kyoung Moo, Wadhwa, Akhilesh, Zubair, Adeel, Wilson, Laura A, Wu, Yanhong, Abell, Thomas L, Hasler, William L, Koch, Kenneth L, McCallum, Richard W, Nguyen, Linda A B, Parkman, Henry P, Sarosiek, Irene, Snape, William J, Tonascia, James, Hamilton, Frank A, Pasricha, Pankaj J, Farrugia, Gianrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Analysis Animals Atherosclerosis Biology and Life Sciences Black or African American - genetics Carbon monoxide Cardiovascular disease Coronary vessels Deoxyribonucleic acid Diabetes Diabetes Complications - genetics Diabetes Complications - pathology Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - pathology Diabetic retinopathy Diabetics DNA Etiology Female Gastric emptying Gastric Emptying - genetics Gastric motility Gastroenterology Gastroparesis Gastroparesis - genetics Gastroparesis - pathology Genes Genetic aspects Genetic polymorphisms Genomics Heme oxygenase (decyclizing) Heme Oxygenase-1 - genetics Humans Male Medicine and Health Sciences Mice Middle Aged Minority & ethnic groups Morbidity Motility Nausea Neurosciences Oxidases People and places Physiological aspects Physiology Polymorphism, Genetic Public health Research and Analysis Methods Risk analysis Risk factors Rodents Statistical analysis Studies Tandem Repeat Sequences - genetics Vomiting
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