Lung and heart-lung transplantation in pulmonary arterial hypertension
Real use of lung (LT) and heart-lung (HLT) transplantation in pulmonary arterial hypertension (PAH) is unknown. The objectives were to describe the indication of these procedures on PAH treatment in a national cohort of PAH patients, and to analyze the potential improvement of its indication in seve...
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| Veröffentlicht in: | PloS one 2017-11, Vol.12 (11), p.e0187811-e0187811 |
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| creator | López-Meseguer, Manuel Quezada, Carlos A Ramon, Maria A Lázaro, María Dos, Laura Lara, Antonio López, Raquel Blanco, Isabel Escribano, Pilar Roman, Antonio |
| description | Real use of lung (LT) and heart-lung (HLT) transplantation in pulmonary arterial hypertension (PAH) is unknown. The objectives were to describe the indication of these procedures on PAH treatment in a national cohort of PAH patients, and to analyze the potential improvement of its indication in severe patients.
Eligibility for LT/HLT was assessed for each deceased patient. Incident patients from REHAP diagnosed between January 2007 and March 2015 and considered eligible for LT/HLT were grouped as follows: those who finally underwent transplantation (LTP) and those who died (D-Non-LT).
Of 1391 patients included in REHAP, 36 (3%) were LTP and 375 (27%) died. Among those who died, 36 (3%) were D-Non-LT. LTP and D-Non-LT were equal in terms of age, gender, and clinical status. Ten percent of those who died were functional class I-II. Patients functional class IV were less likely to undergo LT (8.3% LTP vs. 30.6% D-Non-LT, p = 0.017). Patients with idiopathic and drug/toxin-associated PAH were more likely to undergo LT (44.4% LTP vs. 16.7% D-Non-LT, p = 0.011).
The present results show that the use of LT/HLT could double for this indication. Relevant mortality in early functional class reflects the difficulties in establishing the risk of death in PAH. |
| doi_str_mv | 10.1371/journal.pone.0187811 |
| format | Article |
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Eligibility for LT/HLT was assessed for each deceased patient. Incident patients from REHAP diagnosed between January 2007 and March 2015 and considered eligible for LT/HLT were grouped as follows: those who finally underwent transplantation (LTP) and those who died (D-Non-LT).
Of 1391 patients included in REHAP, 36 (3%) were LTP and 375 (27%) died. Among those who died, 36 (3%) were D-Non-LT. LTP and D-Non-LT were equal in terms of age, gender, and clinical status. Ten percent of those who died were functional class I-II. Patients functional class IV were less likely to undergo LT (8.3% LTP vs. 30.6% D-Non-LT, p = 0.017). Patients with idiopathic and drug/toxin-associated PAH were more likely to undergo LT (44.4% LTP vs. 16.7% D-Non-LT, p = 0.011).
The present results show that the use of LT/HLT could double for this indication. Relevant mortality in early functional class reflects the difficulties in establishing the risk of death in PAH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0187811</identifier><identifier>PMID: 29161284</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Biomedical research ; Blood & organ donations ; Cardiology ; Care and treatment ; Complications and side effects ; Health aspects ; Heart ; Heart transplantation ; Hospitals ; Hypertension ; Indication ; Long-term potentiation ; Lung transplantation ; Medical prognosis ; Medicine and Health Sciences ; Methods ; Mortality ; Patients ; People and Places ; Physiological aspects ; Pulmonary hypertension ; Respiratory diseases ; Transplantation ; Transplants & implants</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0187811-e0187811</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 López-Meseguer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 López-Meseguer et al 2017 López-Meseguer et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-251360dca99a551d8e5c00e4874c9eb2b47b9499389f7691a291c917ce24355d3</citedby><cites>FETCH-LOGICAL-c692t-251360dca99a551d8e5c00e4874c9eb2b47b9499389f7691a291c917ce24355d3</cites><orcidid>0000-0003-2650-9238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697851/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697851/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29161284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Meseguer, Manuel</creatorcontrib><creatorcontrib>Quezada, Carlos A</creatorcontrib><creatorcontrib>Ramon, Maria A</creatorcontrib><creatorcontrib>Lázaro, María</creatorcontrib><creatorcontrib>Dos, Laura</creatorcontrib><creatorcontrib>Lara, Antonio</creatorcontrib><creatorcontrib>López, Raquel</creatorcontrib><creatorcontrib>Blanco, Isabel</creatorcontrib><creatorcontrib>Escribano, Pilar</creatorcontrib><creatorcontrib>Roman, Antonio</creatorcontrib><creatorcontrib>REHAP Investigators</creatorcontrib><creatorcontrib>on behalf of the REHAP Investigators</creatorcontrib><title>Lung and heart-lung transplantation in pulmonary arterial hypertension</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Real use of lung (LT) and heart-lung (HLT) transplantation in pulmonary arterial hypertension (PAH) is unknown. The objectives were to describe the indication of these procedures on PAH treatment in a national cohort of PAH patients, and to analyze the potential improvement of its indication in severe patients.
Eligibility for LT/HLT was assessed for each deceased patient. Incident patients from REHAP diagnosed between January 2007 and March 2015 and considered eligible for LT/HLT were grouped as follows: those who finally underwent transplantation (LTP) and those who died (D-Non-LT).
Of 1391 patients included in REHAP, 36 (3%) were LTP and 375 (27%) died. Among those who died, 36 (3%) were D-Non-LT. LTP and D-Non-LT were equal in terms of age, gender, and clinical status. Ten percent of those who died were functional class I-II. Patients functional class IV were less likely to undergo LT (8.3% LTP vs. 30.6% D-Non-LT, p = 0.017). Patients with idiopathic and drug/toxin-associated PAH were more likely to undergo LT (44.4% LTP vs. 16.7% D-Non-LT, p = 0.011).
The present results show that the use of LT/HLT could double for this indication. 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and heart-lung transplantation in pulmonary arterial hypertension</title><author>López-Meseguer, Manuel ; Quezada, Carlos A ; Ramon, Maria A ; Lázaro, María ; Dos, Laura ; Lara, Antonio ; López, Raquel ; Blanco, Isabel ; Escribano, Pilar ; Roman, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-251360dca99a551d8e5c00e4874c9eb2b47b9499389f7691a291c917ce24355d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Biomedical research</topic><topic>Blood & organ donations</topic><topic>Cardiology</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart transplantation</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Indication</topic><topic>Long-term potentiation</topic><topic>Lung transplantation</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Mortality</topic><topic>Patients</topic><topic>People and Places</topic><topic>Physiological aspects</topic><topic>Pulmonary hypertension</topic><topic>Respiratory diseases</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Meseguer, Manuel</creatorcontrib><creatorcontrib>Quezada, Carlos A</creatorcontrib><creatorcontrib>Ramon, Maria A</creatorcontrib><creatorcontrib>Lázaro, María</creatorcontrib><creatorcontrib>Dos, Laura</creatorcontrib><creatorcontrib>Lara, Antonio</creatorcontrib><creatorcontrib>López, Raquel</creatorcontrib><creatorcontrib>Blanco, Isabel</creatorcontrib><creatorcontrib>Escribano, Pilar</creatorcontrib><creatorcontrib>Roman, Antonio</creatorcontrib><creatorcontrib>REHAP Investigators</creatorcontrib><creatorcontrib>on behalf 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the REHAP Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung and heart-lung transplantation in pulmonary arterial hypertension</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-11-21</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0187811</spage><epage>e0187811</epage><pages>e0187811-e0187811</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Real use of lung (LT) and heart-lung (HLT) transplantation in pulmonary arterial hypertension (PAH) is unknown. The objectives were to describe the indication of these procedures on PAH treatment in a national cohort of PAH patients, and to analyze the potential improvement of its indication in severe patients.
Eligibility for LT/HLT was assessed for each deceased patient. Incident patients from REHAP diagnosed between January 2007 and March 2015 and considered eligible for LT/HLT were grouped as follows: those who finally underwent transplantation (LTP) and those who died (D-Non-LT).
Of 1391 patients included in REHAP, 36 (3%) were LTP and 375 (27%) died. Among those who died, 36 (3%) were D-Non-LT. LTP and D-Non-LT were equal in terms of age, gender, and clinical status. Ten percent of those who died were functional class I-II. Patients functional class IV were less likely to undergo LT (8.3% LTP vs. 30.6% D-Non-LT, p = 0.017). Patients with idiopathic and drug/toxin-associated PAH were more likely to undergo LT (44.4% LTP vs. 16.7% D-Non-LT, p = 0.011).
The present results show that the use of LT/HLT could double for this indication. Relevant mortality in early functional class reflects the difficulties in establishing the risk of death in PAH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29161284</pmid><doi>10.1371/journal.pone.0187811</doi><tpages>e0187811</tpages><orcidid>https://orcid.org/0000-0003-2650-9238</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Biology and Life Sciences Biomedical research Blood & organ donations Cardiology Care and treatment Complications and side effects Health aspects Heart Heart transplantation Hospitals Hypertension Indication Long-term potentiation Lung transplantation Medical prognosis Medicine and Health Sciences Methods Mortality Patients People and Places Physiological aspects Pulmonary hypertension Respiratory diseases Transplantation Transplants & implants |
| title | Lung and heart-lung transplantation in pulmonary arterial hypertension |
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