Biomarkers and echocardiography for evaluating the improvement of the ventricular diastolic function after surgical relief of hydronephrosis
The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarke...
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| creator | Yeh, Huei-Ming Lin, Ting-Tse Yeh, Chih-Fan Huang, Ho-Shiang Chang, Sheng-Nan Lin, Jou-Wei Tsai, Chia-Ti Lai, Ling-Ping Huang, Yi-You Chu, Chun-Lin |
| description | The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarkers and echocardiography. This was a prospective, single-center study. Eighty-seven patients who presented with acute unilateral hydronephrosis and received ureteroscope stone manipulation were enrolled. Echocardiography and cytokines were measured on the day of the operation and 24 hours after the procedure. Changes before and after surgery were assessed by the paired t-test and Wilcoxon test. Correlation analyses between echocardiographic diastolic indices and cytokine levels were performed using Pearson's correlation coefficients. Patients with hydronephrosis showed a higher left atrium volume index (LAVI), decreased E', and increased E/ E' ratio, which indicated diastolic dysfunction. Patients with hydronephrosis also exhibited decreased global strain rates during isovolumetric relaxation (SRIVR) and E/ SRIVR, which confirmed the diastolic dysfunction. Significant reductions in LAVI, increases in SRIVR and decreases in E/ SRIVR were observed after the operation. Biomarkers, such as TGF-β and serum NT-proBNP, were significantly decreased after surgery. In addition, a significant correlation was observed between the post-surgical decrease in TGF-β1 and increase in SRIVR. Unilateral hydronephrosis causes cardiac diastolic dysfunction, and relieving hydronephrosis could improve diastolic function. Improvements in cardiac dysfunction can be evaluated by echocardiography and measuring cytokine levels. The results of this study will inform efforts to improve the early diagnosis of CRS and prevent further deterioration of cardiac function when treating patients with hydronephrosis. |
| doi_str_mv | 10.1371/journal.pone.0188597 |
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Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarkers and echocardiography. This was a prospective, single-center study. Eighty-seven patients who presented with acute unilateral hydronephrosis and received ureteroscope stone manipulation were enrolled. Echocardiography and cytokines were measured on the day of the operation and 24 hours after the procedure. Changes before and after surgery were assessed by the paired t-test and Wilcoxon test. Correlation analyses between echocardiographic diastolic indices and cytokine levels were performed using Pearson's correlation coefficients. Patients with hydronephrosis showed a higher left atrium volume index (LAVI), decreased E', and increased E/ E' ratio, which indicated diastolic dysfunction. Patients with hydronephrosis also exhibited decreased global strain rates during isovolumetric relaxation (SRIVR) and E/ SRIVR, which confirmed the diastolic dysfunction. Significant reductions in LAVI, increases in SRIVR and decreases in E/ SRIVR were observed after the operation. Biomarkers, such as TGF-β and serum NT-proBNP, were significantly decreased after surgery. In addition, a significant correlation was observed between the post-surgical decrease in TGF-β1 and increase in SRIVR. Unilateral hydronephrosis causes cardiac diastolic dysfunction, and relieving hydronephrosis could improve diastolic function. Improvements in cardiac dysfunction can be evaluated by echocardiography and measuring cytokine levels. The results of this study will inform efforts to improve the early diagnosis of CRS and prevent further deterioration of cardiac function when treating patients with hydronephrosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0188597</identifier><identifier>PMID: 29161313</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anesthesiology ; Atrium ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomedical engineering ; Cardiology ; Care and treatment ; Correlation ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Cytokines ; Diagnosis ; Echocardiography ; Feasibility studies ; Heart diseases ; Heart failure ; Hospitals ; Hydronephrosis ; Internal medicine ; Kidneys ; Lithiasis ; Measurement techniques ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Patient outcomes ; Patients ; Peptides ; Physicians ; Physiology ; Research and Analysis Methods ; Surgery ; Transforming growth factor-b1 ; Urolithiasis ; Urology ; Ventricle</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0188597-e0188597</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Yeh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Yeh et al 2017 Yeh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2f2bda994be9552beeb8bb8117737c23d78d52e39360203265c251c353e8909c3</citedby><cites>FETCH-LOGICAL-c692t-2f2bda994be9552beeb8bb8117737c23d78d52e39360203265c251c353e8909c3</cites><orcidid>0000-0001-9122-4437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697892/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697892/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29161313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lionetti, Vincenzo</contributor><creatorcontrib>Yeh, Huei-Ming</creatorcontrib><creatorcontrib>Lin, Ting-Tse</creatorcontrib><creatorcontrib>Yeh, Chih-Fan</creatorcontrib><creatorcontrib>Huang, Ho-Shiang</creatorcontrib><creatorcontrib>Chang, Sheng-Nan</creatorcontrib><creatorcontrib>Lin, Jou-Wei</creatorcontrib><creatorcontrib>Tsai, Chia-Ti</creatorcontrib><creatorcontrib>Lai, Ling-Ping</creatorcontrib><creatorcontrib>Huang, Yi-You</creatorcontrib><creatorcontrib>Chu, Chun-Lin</creatorcontrib><title>Biomarkers and echocardiography for evaluating the improvement of the ventricular diastolic function after surgical relief of hydronephrosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarkers and echocardiography. This was a prospective, single-center study. Eighty-seven patients who presented with acute unilateral hydronephrosis and received ureteroscope stone manipulation were enrolled. Echocardiography and cytokines were measured on the day of the operation and 24 hours after the procedure. Changes before and after surgery were assessed by the paired t-test and Wilcoxon test. Correlation analyses between echocardiographic diastolic indices and cytokine levels were performed using Pearson's correlation coefficients. Patients with hydronephrosis showed a higher left atrium volume index (LAVI), decreased E', and increased E/ E' ratio, which indicated diastolic dysfunction. Patients with hydronephrosis also exhibited decreased global strain rates during isovolumetric relaxation (SRIVR) and E/ SRIVR, which confirmed the diastolic dysfunction. Significant reductions in LAVI, increases in SRIVR and decreases in E/ SRIVR were observed after the operation. Biomarkers, such as TGF-β and serum NT-proBNP, were significantly decreased after surgery. In addition, a significant correlation was observed between the post-surgical decrease in TGF-β1 and increase in SRIVR. Unilateral hydronephrosis causes cardiac diastolic dysfunction, and relieving hydronephrosis could improve diastolic function. Improvements in cardiac dysfunction can be evaluated by echocardiography and measuring cytokine levels. The results of this study will inform efforts to improve the early diagnosis of CRS and prevent further deterioration of cardiac function when treating patients with hydronephrosis.</description><subject>Anesthesiology</subject><subject>Atrium</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomedical engineering</subject><subject>Cardiology</subject><subject>Care and treatment</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Echocardiography</subject><subject>Feasibility studies</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Hydronephrosis</subject><subject>Internal medicine</subject><subject>Kidneys</subject><subject>Lithiasis</subject><subject>Measurement 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and echocardiography for evaluating the improvement of the ventricular diastolic function after surgical relief of hydronephrosis</title><author>Yeh, Huei-Ming ; Lin, Ting-Tse ; Yeh, Chih-Fan ; Huang, Ho-Shiang ; Chang, Sheng-Nan ; Lin, Jou-Wei ; Tsai, Chia-Ti ; Lai, Ling-Ping ; Huang, Yi-You ; Chu, Chun-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2f2bda994be9552beeb8bb8117737c23d78d52e39360203265c251c353e8909c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anesthesiology</topic><topic>Atrium</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomedical engineering</topic><topic>Cardiology</topic><topic>Care and treatment</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation 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Sheng-Nan</au><au>Lin, Jou-Wei</au><au>Tsai, Chia-Ti</au><au>Lai, Ling-Ping</au><au>Huang, Yi-You</au><au>Chu, Chun-Lin</au><au>Lionetti, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers and echocardiography for evaluating the improvement of the ventricular diastolic function after surgical relief of hydronephrosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-11-21</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0188597</spage><epage>e0188597</epage><pages>e0188597-e0188597</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarkers and echocardiography. This was a prospective, single-center study. Eighty-seven patients who presented with acute unilateral hydronephrosis and received ureteroscope stone manipulation were enrolled. Echocardiography and cytokines were measured on the day of the operation and 24 hours after the procedure. Changes before and after surgery were assessed by the paired t-test and Wilcoxon test. Correlation analyses between echocardiographic diastolic indices and cytokine levels were performed using Pearson's correlation coefficients. Patients with hydronephrosis showed a higher left atrium volume index (LAVI), decreased E', and increased E/ E' ratio, which indicated diastolic dysfunction. Patients with hydronephrosis also exhibited decreased global strain rates during isovolumetric relaxation (SRIVR) and E/ SRIVR, which confirmed the diastolic dysfunction. Significant reductions in LAVI, increases in SRIVR and decreases in E/ SRIVR were observed after the operation. Biomarkers, such as TGF-β and serum NT-proBNP, were significantly decreased after surgery. In addition, a significant correlation was observed between the post-surgical decrease in TGF-β1 and increase in SRIVR. Unilateral hydronephrosis causes cardiac diastolic dysfunction, and relieving hydronephrosis could improve diastolic function. Improvements in cardiac dysfunction can be evaluated by echocardiography and measuring cytokine levels. The results of this study will inform efforts to improve the early diagnosis of CRS and prevent further deterioration of cardiac function when treating patients with hydronephrosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29161313</pmid><doi>10.1371/journal.pone.0188597</doi><tpages>e0188597</tpages><orcidid>https://orcid.org/0000-0001-9122-4437</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anesthesiology Atrium Biological markers Biology and Life Sciences Biomarkers Biomedical engineering Cardiology Care and treatment Correlation Correlation analysis Correlation coefficient Correlation coefficients Cytokines Diagnosis Echocardiography Feasibility studies Heart diseases Heart failure Hospitals Hydronephrosis Internal medicine Kidneys Lithiasis Measurement techniques Medical imaging Medicine Medicine and Health Sciences Patient outcomes Patients Peptides Physicians Physiology Research and Analysis Methods Surgery Transforming growth factor-b1 Urolithiasis Urology Ventricle |
| title | Biomarkers and echocardiography for evaluating the improvement of the ventricular diastolic function after surgical relief of hydronephrosis |
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