Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

It has recently been shown that signal peptide peptidase (SPP) can catalyze the intramembrane cleavage of heme oxygenase-1 (HO-1) that leads to translocation of HO-1 into the cytosol and nucleus. While there is consensus that translocated HO-1 promotes tumor progression and drug resistance, the phys...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0188344
Hauptverfasser:	Schaefer, Bianca, Moriishi, Kohji, Behrends, Soenke
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Biological transport Biology and Life Sciences Catalysis Catalytic activity Cell culture Cell Hypoxia Cell Membrane - chemistry Cell Membrane - metabolism Chimeras Cleavage Cloning Cloning, Molecular Confocal microscopy Cytosol Drug resistance Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism HEK293 Cells Heme Heme oxygenase (decyclizing) Heme Oxygenase (Decyclizing) - chemistry Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 - chemistry Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hepatitis Humans Hypoxia Immunoprecipitation Microscopy Mutant Chimeric Proteins - chemistry Mutant Chimeric Proteins - genetics Mutant Chimeric Proteins - metabolism Mutation Oxidases Oxygenase Peptidase Peptides Pests Pharmacology Pharmacy Physical Sciences Physiological aspects Physiology Proteases Protein Interaction Domains and Motifs Protein Transport Proteins Proteolysis Research and Analysis Methods Rodents Scanning microscopy Sequence Alignment Sequence Homology, Amino Acid Signal peptide peptidase Toxicology Translocation
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