Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

We previously reported a high plasma chemokine interferon gamma-inducible protein 10 (IP-10) level and prolonged electrocardiography QT-interval in methadone maintenance treatment (MMT) patients with HIV or HCV infection. The purpose of this study was to evaluate the genetic association of high plas...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187639-e0187639
Hauptverfasser:	Liu, Tung-Hsia, Chung, Ren-Hua, Wang, Sheng-Chang, Fang, Chiu-Ping, Tsou, Hsiao-Hui, Shih, Chia-Lung, Kuo, Hsiang-Wei, Wang, Yun, Liu, Yu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Analysis Bioinformatics Biological response modifiers Biology and Life Sciences Carriers Chemokine CXCL10 - blood Chemokines Claudins - genetics Complications and side effects Diabetes Dosage and administration EKG Electrocardiography Female Genes Genetic aspects Genome-wide association studies Genomes Genomics Health aspects Health sciences HIV Human immunodeficiency virus Humans Infections Interferon Interferon gamma IP-10 protein Male Medical research Medicine and Health Sciences Methadone Methadone - administration & dosage Missense mutation MMT Morphine Morphine - administration & dosage Morphine - urine Mutation Mutation, Missense Opiate Substitution Treatment Patients Physiological aspects Plasma Plasma levels Polymorphism Population Proteins Single-nucleotide polymorphism Studies Substance Abuse Detection - methods Urine γ-Interferon
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