Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload

Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized tha...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187950-e0187950
Hauptverfasser:	Ohba, Takayoshi, Watanabe, Hiroyuki, Murakami, Manabu, Iino, Kenji, Adachi, Takeshi, Baba, Yoshihiro, Kurosaki, Tomohiro, Ono, Kyoichi, Ito, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta Biology and Life Sciences Blood pressure Body weight Brain Brain natriuretic peptide Calcium (reticular) Calcium signalling Cardiac muscle Cardiomyocytes Cardiovascular disease Cellular proteins Development and progression Fetuses Genes Genetic aspects Haploinsufficiency Heart Heart diseases Heart enlargement Heart failure Hypertrophy Immunology Laboratory animals Lymphocytes Medicine Medicine and Health Sciences Mice Musculoskeletal system Mutation Physical Sciences Physiological aspects Physiology Polymerase chain reaction Proteins Research and Analysis Methods Reverse transcription Rodents Sarcoplasmic reticulum Standard error STIM1 protein Stress Stresses Transient receptor potential proteins University graduates
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