Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension
To characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known n...
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| creator | Suzuki, Hideaki Gao, He Bai, Wenjia Evangelou, Evangelos Glocker, Ben O'Regan, Declan P Elliott, Paul Matthews, Paul M |
| description | To characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank.
For assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p |
| doi_str_mv | 10.1371/journal.pone.0187600 |
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For assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction).
The brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group.
Pathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0187600</identifier><identifier>PMID: 29145428</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Alzheimer's disease ; Alzheimers disease ; Biology and Life Sciences ; Blood ; Blood Pressure ; Body mass ; Body mass index ; Body size ; Brain ; Brain research ; Cardiovascular disease ; Cardiovascular diseases ; Cognitive ability ; Concentration (composition) ; Consent ; Councils ; Dementia ; Diabetes mellitus ; Epidemiology ; Female ; Hospitals ; Humans ; Hypertension ; Hypertension - diagnostic imaging ; Hypertension - pathology ; Intracellular ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine and Health Sciences ; Microstructure ; Middle Aged ; Multiple sclerosis ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Physical Sciences ; Physiological aspects ; Public health ; Radiation ; Research and Analysis Methods ; Risk factors ; Smoking ; Social Sciences ; Stroke ; Structure ; Substantia alba ; Thalamus ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0187600-e0187600</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Suzuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Suzuki et al 2017 Suzuki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6b0f053d390d5011503b6cb53e4b78e4b90f72019ca202c7623e82b71c6aa0ef3</citedby><cites>FETCH-LOGICAL-c692t-6b0f053d390d5011503b6cb53e4b78e4b90f72019ca202c7623e82b71c6aa0ef3</cites><orcidid>0000-0002-0410-6940</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690584/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690584/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29145428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lenglet, Christophe</contributor><creatorcontrib>Suzuki, Hideaki</creatorcontrib><creatorcontrib>Gao, He</creatorcontrib><creatorcontrib>Bai, Wenjia</creatorcontrib><creatorcontrib>Evangelou, Evangelos</creatorcontrib><creatorcontrib>Glocker, Ben</creatorcontrib><creatorcontrib>O'Regan, Declan P</creatorcontrib><creatorcontrib>Elliott, Paul</creatorcontrib><creatorcontrib>Matthews, Paul M</creatorcontrib><title>Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank.
For assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction).
The brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group.
Pathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.</description><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood Pressure</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Brain</subject><subject>Brain research</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cognitive ability</subject><subject>Concentration (composition)</subject><subject>Consent</subject><subject>Councils</subject><subject>Dementia</subject><subject>Diabetes 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Sciences</subject><subject>Stroke</subject><subject>Structure</subject><subject>Substantia alba</subject><subject>Thalamus</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - 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brain white matter microstructure is associated with both pre-hypertension and hypertension</title><author>Suzuki, Hideaki ; Gao, He ; Bai, Wenjia ; Evangelou, Evangelos ; Glocker, Ben ; O'Regan, Declan P ; Elliott, Paul ; Matthews, Paul M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6b0f053d390d5011503b6cb53e4b78e4b90f72019ca202c7623e82b71c6aa0ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood Pressure</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Brain</topic><topic>Brain research</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cognitive ability</topic><topic>Concentration 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One</addtitle><date>2017-11-16</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0187600</spage><epage>e0187600</epage><pages>e0187600-e0187600</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank.
For assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction).
The brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group.
Pathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29145428</pmid><doi>10.1371/journal.pone.0187600</doi><orcidid>https://orcid.org/0000-0002-0410-6940</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-11, Vol.12 (11), p.e0187600-e0187600 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Alzheimer's disease Alzheimers disease Biology and Life Sciences Blood Blood Pressure Body mass Body mass index Body size Brain Brain research Cardiovascular disease Cardiovascular diseases Cognitive ability Concentration (composition) Consent Councils Dementia Diabetes mellitus Epidemiology Female Hospitals Humans Hypertension Hypertension - diagnostic imaging Hypertension - pathology Intracellular Magnetic resonance Magnetic Resonance Imaging Male Medical research Medicine and Health Sciences Microstructure Middle Aged Multiple sclerosis Neuroimaging NMR Nuclear magnetic resonance Physical Sciences Physiological aspects Public health Radiation Research and Analysis Methods Risk factors Smoking Social Sciences Stroke Structure Substantia alba Thalamus White Matter - diagnostic imaging White Matter - pathology |
| title | Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T08%3A53%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abnormal%20brain%20white%20matter%20microstructure%20is%20associated%20with%20both%20pre-hypertension%20and%20hypertension&rft.jtitle=PloS%20one&rft.au=Suzuki,%20Hideaki&rft.date=2017-11-16&rft.volume=12&rft.issue=11&rft.spage=e0187600&rft.epage=e0187600&rft.pages=e0187600-e0187600&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0187600&rft_dat=%3Cgale_plos_%3EA514689416%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1965166416&rft_id=info:pmid/29145428&rft_galeid=A514689416&rft_doaj_id=oai_doaj_org_article_3c358dec68e94208b3053ec5fcdc099b&rfr_iscdi=true |