Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

The sequential use of signaling pathways is essential for the guidance of pluripotent progenitors into diverse cell fates. Here, we show that Shp2 exclusively mediates FGF but not PDGF signaling in the neural crest to control lacrimal gland development. In addition to preventing p53-independent apop...

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Veröffentlicht in:	PLoS genetics 2017-10, Vol.13 (10), p.e1007047-e1007047
Hauptverfasser:	Garg, Ankur, Bansal, Mukesh, Gotoh, Noriko, Feng, Gen-Sheng, Zhong, Jian, Wang, Fen, Kariminejad, Ariana, Brooks, Steven, Zhang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aplasia Apoptosis Apoptosis - genetics Aquatic animals Biology and Life Sciences Cancer Cell Differentiation - genetics Cell Lineage - genetics Cellular signal transduction Deactivation Departments Embryos Eye diseases Fibroblast growth factor 10 Fibroblast Growth Factor 10 - genetics Fibroblast growth factors Gene Expression Regulation, Developmental Genes Genetic aspects Homeobox Homeodomain Proteins - genetics Humans Kinases Lacrimal apparatus Lacrimal Apparatus - growth & development Lacrimal Apparatus - metabolism Lacrimal gland and Nasolacrimal duct Medical research Medicine and Health Sciences Mesenchyme Mesoderm - growth & development Mice Molecular biology Morphogenesis Morphogenesis - genetics Neural crest Neural Crest - growth & development Neural stem cells p53 Protein Pathology Physiological aspects Platelet-derived growth factor Pluripotency Pluripotent Stem Cells - metabolism Protein Binding Proteins Reptiles & amphibians Research and Analysis Methods Rodents Signal Transduction Sox10 protein SOXE Transcription Factors - genetics
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