SNPs near the cysteine proteinase cathepsin O gene determine tamoxifen sensitivity in ER[alpha]-positive breast cancer through regulation of BRCA1

Tamoxifen is one of the most commonly employed endocrine therapies for patients with estrogen receptor [alpha] (ER[alpha])-positive breast cancer. Unfortunately the clinical benefit is limited due to intrinsic and acquired drug resistance. We previously reported a genome-wide association study that...

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Veröffentlicht in:	PLoS genetics 2017-10, Vol.13 (10)
Hauptverfasser:	Cairns, Junmei, Ingle, James N, Wickerham, Lawrence D, Weinshilboum, Richard, Liu, Mohan, Wang, Liewei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers BRCA1 protein Breast cancer Cathepsins Cell cycle Cell growth Cell proliferation Clinical trials Cysteine proteinase Disease prevention Dosage and administration Drug interactions Drug resistance Drug therapy Endocrine therapy Estrogen receptors Estrogens Funding Genes Genetic aspects Genome-wide association studies Genomes Genotypes Health aspects Lymphoblastoid cell lines Mass spectroscopy Medical research Pharmacology Poly(ADP-ribose) polymerase Proteinase Proteins Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Tamoxifen Transcription factors
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