The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization

Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on elucid...

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Veröffentlicht in:	PLoS computational biology 2017-10, Vol.13 (10), p.e1005804-e1005804
Hauptverfasser:	Hübel, Niklas, Hosseini-Zare, Mahshid S, Žiburkus, Jokūbas, Ullah, Ghanim
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Astrocytes - drug effects Astrocytes - metabolism Biochemistry Biology and Life Sciences Brain Brain diseases Brain Diseases - metabolism Brain Diseases - pathology Brain research Case studies Cell Size Computational Biology Computational neuroscience Cortex Depolarization Deprivation Dynamics Electrophysiological Phenomena Firing pattern Glucose Glutamate Glutamic Acid - metabolism Headache Hematoma Hemorrhage Hinges Homeostasis In Vitro Techniques Ion Channels - metabolism Ischemia Male Medicine and Health Sciences Membrane Potentials Migraine Models, Neurological N-Methylaspartate - metabolism Neurons Neurons - cytology Neurons - metabolism Neurosciences Osmosis Oxygen Perfusion Physiological aspects Physiology Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Rodents Signaling Software Spreading Spreading depression Stroke Subarachnoid hemorrhage Trauma Traumatic brain injury Visual Cortex - drug effects Visual Cortex - metabolism
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