Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle

Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient antivirals against HCV are needed. Compounds isol...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187857-e0187857
Hauptverfasser:	Shimizu, Jacqueline Farinha, Pereira, Carina Machado, Bittar, Cintia, Batista, Mariana Nogueira, Campos, Guilherme Rodrigues Fernandes, da Silva, Suely, Cintra, Adélia Cristina Oliveira, Zothner, Carsten, Harris, Mark, Sampaio, Suely Vilela, Aquino, Victor Hugo, Rahal, Paula, Jardim, Ana Carolina Gomes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral drugs Biology and Life Sciences Cell Line Cellular biology Crotalid Venoms - chemistry Crotalus Crotalus durissus terrificus Crotoxin Crotoxin - chemistry Crotoxin - pharmacology Crystal structure Crystallography, X-Ray Dengue Dengue fever Drug therapy Fever Genomics Hepacivirus - drug effects Hepacivirus - physiology Hepatitis Hepatitis C Humans Infections Interferon Laboratories Life cycle engineering Life cycles Lipids Liver Liver diseases Liver transplantation Measles Medicine and Health Sciences Membrane Fusion - drug effects Molecular biology Molecular Structure Pharmaceutical sciences Phospholipase Phospholipase A2 Phospholipases A2 - chemistry Phospholipases A2 - pharmacology Properties Proteins Replication Side effects Snakes Toxins Transplantation Vector-borne diseases Venom Viral diseases Virology Virus Replication - drug effects Viruses
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