The efficacy of chimeric antigen receptor (CAR) immunotherapy in animal models for solid tumors: A systematic review and meta-analysis

Most recently, an emerging theme in the field of tumor immunology predominates: chimeric antigen receptor (CAR) therapy in treating solid tumors. The number of related preclinical trials was surging. However, an evaluation of the effects of preclinical studies remained absent. Hence, a meta-analysis...

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Veröffentlicht in:PloS one 2017-11, Vol.12 (11), p.e0187902-e0187902
Hauptverfasser: Wu, Yingcheng, Xu, Ran, Jia, Keren, Shi, Hui
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description Most recently, an emerging theme in the field of tumor immunology predominates: chimeric antigen receptor (CAR) therapy in treating solid tumors. The number of related preclinical trials was surging. However, an evaluation of the effects of preclinical studies remained absent. Hence, a meta-analysis was conducted on the efficacy of CAR in animal models for solid tumors. The authors searched PubMed/Medline, Embase, and Google scholar up to April 2017. HR for survival was extracted based on the survival curve. The authors used fixed effect models to combine the results of all the trials. Heterogeneity was assessed by I-square statistic. Quality assessment was conducted following the Stroke Therapy Academic Industry Roundtable standard. Publication bias was assessed using Egger's test. Eleven trials were included, including 54 experiments with a total of 362 animals involved. CAR immunotherapy significantly improved the survival of animals (HR: 0.25, 95% CI: 0.13-0.37, P < 0.001). The quality assessment revealed that no study reported whether allocation concealment and blinded outcome assessment were conducted, and only five studies implemented randomization. This meta-analysis indicated that CAR therapy may be a potential clinical strategy in treating solid tumors.
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subjects Animal models
Animals
Antigens
Bias
Biology and Life Sciences
Care and treatment
Chimeric antigen receptors
Clinical trials
Cytokines
Disease Models, Animal
Gene therapy
Humans
Immunology
Immunotherapy
Lymphocytes
Medical research
Medicine and Health Sciences
Meta-analysis
Methods
Neoplasms - therapy
Ovarian cancer
Pancreatic cancer
Physical Sciences
Quality assessment
Quality control
Receptors, Antigen - immunology
Receptors, Antigen - therapeutic use
Recombinant Fusion Proteins - immunology
Recombinant Fusion Proteins - therapeutic use
Research and Analysis Methods
Scientific papers
Search engines
Solid tumors
Stroke
Studies
Survival
Therapy
Thoracic surgery
Tumors
title The efficacy of chimeric antigen receptor (CAR) immunotherapy in animal models for solid tumors: A systematic review and meta-analysis
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