Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals

Blood based Interferon-(IFN)-γ release assays (IGRAs) have a poor predictive value for the development of tuberculosis. This study aimed to investigate the correlation between IGRAs and pulmonary immune responses in tuberculosis contacts in Germany. IGRAs were performed on bronchoalveolar lavage (BA...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187882-e0187882
Hauptverfasser:	Herzmann, Christian, Ernst, Martin, Lange, Christoph, Stenger, Steffen, Kaufmann, Stefan H E, Reiling, Norbert, Schaberg, Tom, van der Merwe, Lize, Maertzdorf, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Antigens Biology Biology and Life Sciences Biomarkers Blood Bronchoalveolar lavage Bronchoalveolar Lavage Fluid Bronchus Cell activation Cell culture Chemokines Consortia Correlation Correlation analysis Cytokines Cytometry Data collection Development and progression ESAT-6 antigen Filtrate Flow cytometry Gene expression Genetic aspects Germany Humans Immune response Immunity Immunology Infections Infectious diseases Interferon Interleukin Interleukin 2 Lung - immunology Lymphocytes Macrophages Medicine and Health Sciences Multiplexing Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Peripheral blood Physiological aspects Proteins Stimulation Studies Tuberculin Tuberculosis γ-Interferon
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