Dosimetric comparison of CT-guided iodine-125 seed stereotactic brachytherapy and stereotactic body radiation therapy in the treatment of NSCLC
This study aimed to assess the dosimetric differences between iodine-125 seed stereotactic brachytherapy (SBT) and stereotactic body radiation therapy (SBRT) in the treatment of non-small cell lung cancer (NSCLC). An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Presc...
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| creator | Li, Ranran Zhang, Ying Yuan, Yuan Lin, Qi Dai, Jianjian Xu, Ruicai Hu, Xudong Han, Mingyong |
| description | This study aimed to assess the dosimetric differences between iodine-125 seed stereotactic brachytherapy (SBT) and stereotactic body radiation therapy (SBRT) in the treatment of non-small cell lung cancer (NSCLC). An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Prescription of the dose and fractionation (fr) for SBRT was 48Gy/4fr. The planning aim for SBT was D90 (dose delivered to 90% of the target volume)≥120Gy. Student's paired t test was used to compare the dosimetric parameters. The SBT and SBRT plans had comparable PTV D90 (104.73±2.10Gyvs.107.64±2.29Gy), and similar mean volume receiving 100% of the prescription dose (V100%) (91.65% vs.92.44%, p = 0.410). The mean volume receiving 150% of the prescribed dose (V150%) for SBT was 64.71%, whereas it was 0% for SBRT. Mean heterogeneity index (HI) deviation for SBT vs. SBRT was 0.73 vs. 0.19 (p |
| doi_str_mv | 10.1371/journal.pone.0187390 |
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An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Prescription of the dose and fractionation (fr) for SBRT was 48Gy/4fr. The planning aim for SBT was D90 (dose delivered to 90% of the target volume)≥120Gy. Student's paired t test was used to compare the dosimetric parameters. The SBT and SBRT plans had comparable PTV D90 (104.73±2.10Gyvs.107.64±2.29Gy), and similar mean volume receiving 100% of the prescription dose (V100%) (91.65% vs.92.44%, p = 0.410). The mean volume receiving 150% of the prescribed dose (V150%) for SBT was 64.71%, whereas it was 0% for SBRT. Mean heterogeneity index (HI) deviation for SBT vs. SBRT was 0.73 vs. 0.19 (p<0.0001), and the mean conformity index (CI) for SBT vs. SBRT was 0.77 vs. 0.81 (p = 0.031). The mean lung doses (MLD) in SBT were significantly lower than those in SBRT (1.952±0.713 vs. 5.618±2.009, p<0.0001). In conclusion, compared with SBRT, SBT can generate a comparable dose within PTV, while the organs at risk (OARs) only receive a very low dose. But the HI and CI in SBT were lower than in SBRT.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0187390</identifier><identifier>PMID: 29121047</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and Life Sciences ; Brachytherapy ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; Care and treatment ; Comparative analysis ; Dosage and administration ; Dose-Response Relationship, Radiation ; Dosimetry ; Esophagus ; Female ; Fractionation ; Health aspects ; Heart ; Humans ; Iodine ; Iodine Radioisotopes - chemistry ; Lung cancer ; Lung diseases ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - radiotherapy ; Male ; Medicine and Health Sciences ; Middle Aged ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Oncology ; Organs ; Organs at Risk ; Patient outcomes ; Patients ; Planning ; Radiation ; Radiation therapy ; Radiosurgery ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Research and Analysis Methods ; Seeds ; Spinal cord ; Studies ; Tomography, X-Ray Computed</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0187390-e0187390</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Li et al 2017 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-70a660961035fba4d6cb3761ec5d7b315d257b745c26cd8f691e28b2418cb5093</citedby><cites>FETCH-LOGICAL-c692t-70a660961035fba4d6cb3761ec5d7b315d257b745c26cd8f691e28b2418cb5093</cites><orcidid>0000-0001-6563-2082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679513/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679513/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29121047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Multhoff, Gabriele</contributor><creatorcontrib>Li, Ranran</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Lin, Qi</creatorcontrib><creatorcontrib>Dai, Jianjian</creatorcontrib><creatorcontrib>Xu, Ruicai</creatorcontrib><creatorcontrib>Hu, Xudong</creatorcontrib><creatorcontrib>Han, Mingyong</creatorcontrib><title>Dosimetric comparison of CT-guided iodine-125 seed stereotactic brachytherapy and stereotactic body radiation therapy in the treatment of NSCLC</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to assess the dosimetric differences between iodine-125 seed stereotactic brachytherapy (SBT) and stereotactic body radiation therapy (SBRT) in the treatment of non-small cell lung cancer (NSCLC). An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Prescription of the dose and fractionation (fr) for SBRT was 48Gy/4fr. The planning aim for SBT was D90 (dose delivered to 90% of the target volume)≥120Gy. Student's paired t test was used to compare the dosimetric parameters. The SBT and SBRT plans had comparable PTV D90 (104.73±2.10Gyvs.107.64±2.29Gy), and similar mean volume receiving 100% of the prescription dose (V100%) (91.65% vs.92.44%, p = 0.410). The mean volume receiving 150% of the prescribed dose (V150%) for SBT was 64.71%, whereas it was 0% for SBRT. Mean heterogeneity index (HI) deviation for SBT vs. SBRT was 0.73 vs. 0.19 (p<0.0001), and the mean conformity index (CI) for SBT vs. SBRT was 0.77 vs. 0.81 (p = 0.031). The mean lung doses (MLD) in SBT were significantly lower than those in SBRT (1.952±0.713 vs. 5.618±2.009, p<0.0001). In conclusion, compared with SBRT, SBT can generate a comparable dose within PTV, while the organs at risk (OARs) only receive a very low dose. But the HI and CI in SBT were lower than in SBRT.</description><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Brachytherapy</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Dosimetry</subject><subject>Esophagus</subject><subject>Female</subject><subject>Fractionation</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Iodine</subject><subject>Iodine Radioisotopes - chemistry</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncology</subject><subject>Organs</subject><subject>Organs at Risk</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Planning</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiosurgery</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Research and Analysis Methods</subject><subject>Seeds</subject><subject>Spinal cord</subject><subject>Studies</subject><subject>Tomography, X-Ray Computed</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggiISG42MWH2IlvkKrlVGlFJVq4tSa2s-tVEm9tB7FPwSvjdNOqW_UC-SI-fP8_mbEny15iNMe0xB82bvA9tPOt680c4aqkAj3KjrGgZMYJoo_vzI-yZyFsEGK04vxpdkQEJhgV5XH295MLtjPRW5Ur123B2-D63DX54nK2Gqw2OrdO297MMGF5MGkdovHGRVAxiWoPar2La-Nhu8uhv3_s9C73oC1Em3xvOHs9zaM3EDvTxzHg94vFcvE8e9JAG8yL6XuS_fzy-XLxbbY8_3q2OF3OFBckzkoEnCPBMaKsqaHQXNW05NgopsuaYqYJK-uyYIpwpauGC2xIVZMCV6pmSNCT7PXed9u6IKdaBokFJ4RzXo3E2Z7QDjZy620HficdWHm94fxKgk8ptkY2AumGQ1MUjBW8ZpWoMQBDlaa8BsyT18cp2lB3RquUsYf2wPTwpLdruXK_JeOlYJgmg3eTgXdXgwlRdjYo07bQGzdc_zclZcn4iL65hz6c3UStICVg-8aluGo0lacpoBCUliM1f4BKQ5vOqvTwGpv2DwTvDwSJieZPXMEQgjy7-PH_7PmvQ_btHXZtoI3r4NphfFThECz2oPIuBG-a2yJjJMe-uamGHPtGTn2TZK_uXtCt6KZR6D9HbBOq</recordid><startdate>20171109</startdate><enddate>20171109</enddate><creator>Li, 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comparison of CT-guided iodine-125 seed stereotactic brachytherapy and stereotactic body radiation therapy in the treatment of NSCLC</title><author>Li, Ranran ; Zhang, Ying ; Yuan, Yuan ; Lin, Qi ; Dai, Jianjian ; Xu, Ruicai ; Hu, Xudong ; Han, Mingyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-70a660961035fba4d6cb3761ec5d7b315d257b745c26cd8f691e28b2418cb5093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Brachytherapy</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - radiotherapy</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Dosimetry</topic><topic>Esophagus</topic><topic>Female</topic><topic>Fractionation</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Humans</topic><topic>Iodine</topic><topic>Iodine Radioisotopes - chemistry</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Oncology</topic><topic>Organs</topic><topic>Organs at Risk</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Planning</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Radiosurgery</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><topic>Research and Analysis Methods</topic><topic>Seeds</topic><topic>Spinal 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ranran</au><au>Zhang, Ying</au><au>Yuan, Yuan</au><au>Lin, Qi</au><au>Dai, Jianjian</au><au>Xu, Ruicai</au><au>Hu, Xudong</au><au>Han, Mingyong</au><au>Multhoff, Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric comparison of CT-guided iodine-125 seed stereotactic brachytherapy and stereotactic body radiation therapy in the treatment of NSCLC</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-11-09</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0187390</spage><epage>e0187390</epage><pages>e0187390-e0187390</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to assess the dosimetric differences between iodine-125 seed stereotactic brachytherapy (SBT) and stereotactic body radiation therapy (SBRT) in the treatment of non-small cell lung cancer (NSCLC). An SBT plan and an SBRT plan were generated for eleven patients with T1-2 NSCLC. Prescription of the dose and fractionation (fr) for SBRT was 48Gy/4fr. The planning aim for SBT was D90 (dose delivered to 90% of the target volume)≥120Gy. Student's paired t test was used to compare the dosimetric parameters. The SBT and SBRT plans had comparable PTV D90 (104.73±2.10Gyvs.107.64±2.29Gy), and similar mean volume receiving 100% of the prescription dose (V100%) (91.65% vs.92.44%, p = 0.410). The mean volume receiving 150% of the prescribed dose (V150%) for SBT was 64.71%, whereas it was 0% for SBRT. Mean heterogeneity index (HI) deviation for SBT vs. SBRT was 0.73 vs. 0.19 (p<0.0001), and the mean conformity index (CI) for SBT vs. SBRT was 0.77 vs. 0.81 (p = 0.031). The mean lung doses (MLD) in SBT were significantly lower than those in SBRT (1.952±0.713 vs. 5.618±2.009, p<0.0001). In conclusion, compared with SBRT, SBT can generate a comparable dose within PTV, while the organs at risk (OARs) only receive a very low dose. But the HI and CI in SBT were lower than in SBRT.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29121047</pmid><doi>10.1371/journal.pone.0187390</doi><tpages>e0187390</tpages><orcidid>https://orcid.org/0000-0001-6563-2082</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2017-11, Vol.12 (11), p.e0187390-e0187390 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Biology and Life Sciences Brachytherapy Cancer therapies Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - radiotherapy Care and treatment Comparative analysis Dosage and administration Dose-Response Relationship, Radiation Dosimetry Esophagus Female Fractionation Health aspects Heart Humans Iodine Iodine Radioisotopes - chemistry Lung cancer Lung diseases Lung Neoplasms - diagnostic imaging Lung Neoplasms - radiotherapy Male Medicine and Health Sciences Middle Aged Non-small cell lung cancer Non-small cell lung carcinoma Oncology Organs Organs at Risk Patient outcomes Patients Planning Radiation Radiation therapy Radiosurgery Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Research and Analysis Methods Seeds Spinal cord Studies Tomography, X-Ray Computed |
| title | Dosimetric comparison of CT-guided iodine-125 seed stereotactic brachytherapy and stereotactic body radiation therapy in the treatment of NSCLC |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T01%3A10%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dosimetric%20comparison%20of%20CT-guided%20iodine-125%20seed%20stereotactic%20brachytherapy%20and%20stereotactic%20body%20radiation%20therapy%20in%20the%20treatment%20of%20NSCLC&rft.jtitle=PloS%20one&rft.au=Li,%20Ranran&rft.date=2017-11-09&rft.volume=12&rft.issue=11&rft.spage=e0187390&rft.epage=e0187390&rft.pages=e0187390-e0187390&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0187390&rft_dat=%3Cgale_plos_%3EA513993379%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1962266689&rft_id=info:pmid/29121047&rft_galeid=A513993379&rft_doaj_id=oai_doaj_org_article_f90df6af445546b589b1aa508d36ba16&rfr_iscdi=true |