Respiratory syncytial virus elicits enriched CD8+ T lymphocyte responses in lung compared with blood in African green monkeys

Respiratory syncytial virus (RSV) is a leading cause of serious lower respiratory tract disease in young children and older adults throughout the world. Prevention of severe RSV disease through active immunization is optimal but no RSV vaccine has been licensed so far. Immune mechanisms of protectio...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187642-e0187642
Hauptverfasser:	Li, Hualin, Callahan, Cheryl, Citron, Michael, Wen, Zhiyun, Touch, Sinoeun, Monslow, Morgan A, Cox, Kara S, DiStefano, Daniel J, Vora, Kalpit A, Bett, Andrew, Espeseth, Amy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antigens, CD - blood Antigens, CD - immunology Biology and Life Sciences Blood CD103 antigen CD28 antigen CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD69 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD95 antigen Cell adhesion & migration Children Chlorocebus aethiops Correlation analysis Fusion protein Immune clearance Immune response (cell-mediated) Immune response (humoral) Immunity, Cellular Immunization Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunologic Memory Immunological memory Immunology Infections Infectious diseases Influenza Kinetics Lung - immunology Lung - metabolism Lungs Lymphocytes Lymphocytes T Medicine and Health Sciences Monkeys Older people Peripheral blood Proteins Research and Analysis Methods Respiratory syncytial virus Respiratory Syncytial Virus Infections - blood Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Viruses - immunology Respiratory Syncytial Viruses - metabolism Respiratory tract Respiratory tract diseases Studies Vaccines Viral infections Viruses Young adults
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