Impact of inability to turn in bed assessed by a wearable three-axis accelerometer on patients with Parkinson's disease
Difficulty turning over in bed is a common night-time symptom in Parkinson's disease (PD). We aimed to quantitatively evaluate overnight turnover movements using a three-axis accelerometer and to investigate whether inability to turn in bed is related to daytime sleepiness, sleep quality, and d...
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| creator | Uchino, Kenji Shiraishi, Makoto Tanaka, Keita Akamatsu, Masashi Hasegawa, Yasuhiro |
| description | Difficulty turning over in bed is a common night-time symptom in Parkinson's disease (PD). We aimed to quantitatively evaluate overnight turnover movements using a three-axis accelerometer and to investigate whether inability to turn in bed is related to daytime sleepiness, sleep quality, and depressive mood in PD patients.
We examined 64 patients with PD (mean age, 73.3±8.21 years; modified Hoehn-Yahr [mH-Y] stage, 3.0±1.0; disease duration, 7.2±6.3 years; unified Parkinson's disease rating scale [UPDRS], 36.9±18.3). Overnight monitoring of turnover movements using a wearable three-axis accelerometer was performed in all patients. Nocturnal kinetic parameters including total time recumbent, total time supine, number of turnover movements, and mean interval between turnover movements were obtained. Daytime immobility was assessed using the Barthel index (B-I), UPDRS, and mH-Y stage. Patients were also assessed with the Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale-2 (PDSS-2), and Beck Depression Inventory (BDI).
Number of turnover movements in bed correlated negatively with disease duration (r = -0.305; p |
| doi_str_mv | 10.1371/journal.pone.0187616 |
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We examined 64 patients with PD (mean age, 73.3±8.21 years; modified Hoehn-Yahr [mH-Y] stage, 3.0±1.0; disease duration, 7.2±6.3 years; unified Parkinson's disease rating scale [UPDRS], 36.9±18.3). Overnight monitoring of turnover movements using a wearable three-axis accelerometer was performed in all patients. Nocturnal kinetic parameters including total time recumbent, total time supine, number of turnover movements, and mean interval between turnover movements were obtained. Daytime immobility was assessed using the Barthel index (B-I), UPDRS, and mH-Y stage. Patients were also assessed with the Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale-2 (PDSS-2), and Beck Depression Inventory (BDI).
Number of turnover movements in bed correlated negatively with disease duration (r = -0.305; p<0.05), L-dopa-equivalent dose (r = -0.281; p<0.05), mH-Y staging (r = -0.336; p<0.01), total score of UPDRS (r = -0.386; p<0.01) and positively with B-I score (r = 0.365; p<0.01). Number of turnover movements in bed was generally inconsistent with awareness of turnover movement impairment as evaluated by PDSS-2 Item 9 scores, but patients who were never aware of impaired turnover movements showed ≥5 turnover movements overnight. Multivariate logistic regression analyses revealed no correlations between number of nocturnal turnover movements in bed and BDI, ESS, or PDSS-2. Use of anti-psychotic drugs was associated with ESS (p = 0.045). UPDRS was associated with PDSS-2 (p = 0.016).
Decreased number of turnover movements may not be a direct determinant of daytime sleepiness, sleep disorders, or depressive mood in PD patients. Use of anti-psychotic drugs and higher UPDRS score are factors significantly associated with daytime sleepiness and uncomfortable sleep, respectively.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0187616</identifier><identifier>PMID: 29121638</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accelerometers ; Accelerometry - instrumentation ; Accelerometry - methods ; Aged ; Aged, 80 and over ; Antipsychotic agents ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - adverse effects ; Beds ; Biology and Life Sciences ; Correlation analysis ; Daytime ; Depression - drug therapy ; Depression - physiopathology ; Depression - psychology ; Diagnosis ; Dihydroxyphenylalanine ; Drugs ; Engineering and Technology ; Female ; Health aspects ; Humans ; Levodopa ; Male ; Medicine ; Medicine and Health Sciences ; Mental depression ; Mood ; Movement ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Parkinson disease ; Parkinson Disease - drug therapy ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; Parkinson's disease ; Patients ; Physical Sciences ; Physiological aspects ; Regression analysis ; Research and Analysis Methods ; Sensors ; Sleep ; Sleep - drug effects ; Sleep and wakefulness ; Sleep disorders ; Sleep movements ; Sleepiness ; Wearable technology</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0187616-e0187616</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Uchino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Uchino et al 2017 Uchino et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-108bf6c74bc11d712d008dbadc489477e4a16febea5cde9892c8b64300daf67c3</citedby><cites>FETCH-LOGICAL-c692t-108bf6c74bc11d712d008dbadc489477e4a16febea5cde9892c8b64300daf67c3</cites><orcidid>0000-0003-0822-1599</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679594/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679594/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29121638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Veauthier, Christian</contributor><creatorcontrib>Uchino, Kenji</creatorcontrib><creatorcontrib>Shiraishi, Makoto</creatorcontrib><creatorcontrib>Tanaka, Keita</creatorcontrib><creatorcontrib>Akamatsu, Masashi</creatorcontrib><creatorcontrib>Hasegawa, Yasuhiro</creatorcontrib><title>Impact of inability to turn in bed assessed by a wearable three-axis accelerometer on patients with Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Difficulty turning over in bed is a common night-time symptom in Parkinson's disease (PD). We aimed to quantitatively evaluate overnight turnover movements using a three-axis accelerometer and to investigate whether inability to turn in bed is related to daytime sleepiness, sleep quality, and depressive mood in PD patients.
We examined 64 patients with PD (mean age, 73.3±8.21 years; modified Hoehn-Yahr [mH-Y] stage, 3.0±1.0; disease duration, 7.2±6.3 years; unified Parkinson's disease rating scale [UPDRS], 36.9±18.3). Overnight monitoring of turnover movements using a wearable three-axis accelerometer was performed in all patients. Nocturnal kinetic parameters including total time recumbent, total time supine, number of turnover movements, and mean interval between turnover movements were obtained. Daytime immobility was assessed using the Barthel index (B-I), UPDRS, and mH-Y stage. Patients were also assessed with the Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale-2 (PDSS-2), and Beck Depression Inventory (BDI).
Number of turnover movements in bed correlated negatively with disease duration (r = -0.305; p<0.05), L-dopa-equivalent dose (r = -0.281; p<0.05), mH-Y staging (r = -0.336; p<0.01), total score of UPDRS (r = -0.386; p<0.01) and positively with B-I score (r = 0.365; p<0.01). Number of turnover movements in bed was generally inconsistent with awareness of turnover movement impairment as evaluated by PDSS-2 Item 9 scores, but patients who were never aware of impaired turnover movements showed ≥5 turnover movements overnight. Multivariate logistic regression analyses revealed no correlations between number of nocturnal turnover movements in bed and BDI, ESS, or PDSS-2. Use of anti-psychotic drugs was associated with ESS (p = 0.045). UPDRS was associated with PDSS-2 (p = 0.016).
Decreased number of turnover movements may not be a direct determinant of daytime sleepiness, sleep disorders, or depressive mood in PD patients. Use of anti-psychotic drugs and higher UPDRS score are factors significantly associated with daytime sleepiness and uncomfortable sleep, respectively.</description><subject>Accelerometers</subject><subject>Accelerometry - instrumentation</subject><subject>Accelerometry - methods</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antipsychotic agents</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Beds</subject><subject>Biology and Life Sciences</subject><subject>Correlation analysis</subject><subject>Daytime</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Depression - psychology</subject><subject>Diagnosis</subject><subject>Dihydroxyphenylalanine</subject><subject>Drugs</subject><subject>Engineering and Technology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Levodopa</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Mood</subject><subject>Movement</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Sensors</subject><subject>Sleep</subject><subject>Sleep - drug effects</subject><subject>Sleep and wakefulness</subject><subject>Sleep disorders</subject><subject>Sleep movements</subject><subject>Sleepiness</subject><subject>Wearable technology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rHCEUhofS0qRp_0FphUI_LnarjuPoTSGEfiwEUvp1K2f0zK7p7LhRt8n--5pkE7IlF0VBOT7nVV89VfWc0SmrW_b-NKzjCMN0FUacUqZayeSDap_pmk8kp_XDO_O96klKp5Q2tZLycbXHNeNM1mq_Op8tV2AzCT3xI3R-8HlDciC5iJcI6dARSAlLd6TbECDnCBG6AUleRMQJXPhEwFocMIYlZowkjGQF2eOYEzn3eUG-QvztxxTGN4k4nxASPq0e9TAkfLYdD6qfnz7-OPoyOT75PDs6PJ5YqXmeMKq6XtpWdJYx1zLuKFWuA2eF0qJtUQCTPXYIjXWoleZWdVLUlDroZWvrg-rlte5qCMlsPUuGacm5UJy2hZhdEy7AqVlFv4S4MQG8uQqEODcQs7cDGtaxWmohet0KwYQCKZHTptdOKQmqL1oftrutuyU6WyyIMOyI7q6MfmHm4Y9pZKsbLYrA261ADGdrTNksfSreDjBiWF-du-at4qwp6Kt_0Ptvt6XmUC7gxz6Ufe2lqDlsWK11XXNdqOk9VGkOl96WD9b7Et9JeLeTUJiMF3kO65TM7Pu3_2dPfu2yr--wC4QhL1IY1tmHMe2C4hq0MaQUsb81mVFzWR83bpjL-jDb-ihpL-4-0G3STUHUfwE5EQuJ</recordid><startdate>20171109</startdate><enddate>20171109</enddate><creator>Uchino, Kenji</creator><creator>Shiraishi, Makoto</creator><creator>Tanaka, Keita</creator><creator>Akamatsu, Masashi</creator><creator>Hasegawa, Yasuhiro</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0822-1599</orcidid></search><sort><creationdate>20171109</creationdate><title>Impact of inability to turn in bed assessed by a wearable three-axis accelerometer on patients with Parkinson's disease</title><author>Uchino, Kenji ; Shiraishi, Makoto ; Tanaka, Keita ; Akamatsu, Masashi ; Hasegawa, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-108bf6c74bc11d712d008dbadc489477e4a16febea5cde9892c8b64300daf67c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accelerometers</topic><topic>Accelerometry - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchino, Kenji</au><au>Shiraishi, Makoto</au><au>Tanaka, Keita</au><au>Akamatsu, Masashi</au><au>Hasegawa, Yasuhiro</au><au>Veauthier, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of inability to turn in bed assessed by a wearable three-axis accelerometer on patients with Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-11-09</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0187616</spage><epage>e0187616</epage><pages>e0187616-e0187616</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Difficulty turning over in bed is a common night-time symptom in Parkinson's disease (PD). We aimed to quantitatively evaluate overnight turnover movements using a three-axis accelerometer and to investigate whether inability to turn in bed is related to daytime sleepiness, sleep quality, and depressive mood in PD patients.
We examined 64 patients with PD (mean age, 73.3±8.21 years; modified Hoehn-Yahr [mH-Y] stage, 3.0±1.0; disease duration, 7.2±6.3 years; unified Parkinson's disease rating scale [UPDRS], 36.9±18.3). Overnight monitoring of turnover movements using a wearable three-axis accelerometer was performed in all patients. Nocturnal kinetic parameters including total time recumbent, total time supine, number of turnover movements, and mean interval between turnover movements were obtained. Daytime immobility was assessed using the Barthel index (B-I), UPDRS, and mH-Y stage. Patients were also assessed with the Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale-2 (PDSS-2), and Beck Depression Inventory (BDI).
Number of turnover movements in bed correlated negatively with disease duration (r = -0.305; p<0.05), L-dopa-equivalent dose (r = -0.281; p<0.05), mH-Y staging (r = -0.336; p<0.01), total score of UPDRS (r = -0.386; p<0.01) and positively with B-I score (r = 0.365; p<0.01). Number of turnover movements in bed was generally inconsistent with awareness of turnover movement impairment as evaluated by PDSS-2 Item 9 scores, but patients who were never aware of impaired turnover movements showed ≥5 turnover movements overnight. Multivariate logistic regression analyses revealed no correlations between number of nocturnal turnover movements in bed and BDI, ESS, or PDSS-2. Use of anti-psychotic drugs was associated with ESS (p = 0.045). UPDRS was associated with PDSS-2 (p = 0.016).
Decreased number of turnover movements may not be a direct determinant of daytime sleepiness, sleep disorders, or depressive mood in PD patients. Use of anti-psychotic drugs and higher UPDRS score are factors significantly associated with daytime sleepiness and uncomfortable sleep, respectively.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29121638</pmid><doi>10.1371/journal.pone.0187616</doi><tpages>e0187616</tpages><orcidid>https://orcid.org/0000-0003-0822-1599</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1962248207 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Accelerometers Accelerometry - instrumentation Accelerometry - methods Aged Aged, 80 and over Antipsychotic agents Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Beds Biology and Life Sciences Correlation analysis Daytime Depression - drug therapy Depression - physiopathology Depression - psychology Diagnosis Dihydroxyphenylalanine Drugs Engineering and Technology Female Health aspects Humans Levodopa Male Medicine Medicine and Health Sciences Mental depression Mood Movement Movement disorders Neurodegenerative diseases Neurology Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson's disease Patients Physical Sciences Physiological aspects Regression analysis Research and Analysis Methods Sensors Sleep Sleep - drug effects Sleep and wakefulness Sleep disorders Sleep movements Sleepiness Wearable technology |
| title | Impact of inability to turn in bed assessed by a wearable three-axis accelerometer on patients with Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T14%3A11%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20inability%20to%20turn%20in%20bed%20assessed%20by%20a%20wearable%20three-axis%20accelerometer%20on%20patients%20with%20Parkinson's%20disease&rft.jtitle=PloS%20one&rft.au=Uchino,%20Kenji&rft.date=2017-11-09&rft.volume=12&rft.issue=11&rft.spage=e0187616&rft.epage=e0187616&rft.pages=e0187616-e0187616&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0187616&rft_dat=%3Cgale_plos_%3EA513993329%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1962248207&rft_id=info:pmid/29121638&rft_galeid=A513993329&rft_doaj_id=oai_doaj_org_article_1b136944f9744148a66e205f9d886a8f&rfr_iscdi=true |