Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model

Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalit...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187419-e0187419
Hauptverfasser:	Cagle, Laura A, Franzi, Lisa M, Linderholm, Angela L, Last, Jerold A, Adams, Jason Y, Harper, Richart W, Kenyon, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult respiratory distress syndrome Alveoli Analysis Animal models Animals Biology Biology and Life Sciences Bronchoalveolar lavage Bronchoalveolar Lavage Fluid Bronchus Capillary pressure Critical care Cytokines Development and progression Disease Models, Animal Female Histology Inflammation Injury prevention Intensive care Leukocytes (neutrophilic) Lungs Maneuvers Mechanical ventilation Mechanics Medicine Medicine and Health Sciences Mice Mice, Inbred BALB C Neutrophils Positive-Pressure Respiration - methods Pressure Prevention Recruitment Research and Analysis Methods Respiration, Artificial - adverse effects Respiratory distress syndrome Respiratory therapy Short term Sleep Studies Ventilation Ventilators
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