Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities
Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more tha...
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| description | Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more than 10% (right > left asymmetry) or less than -10% (left > right asymmetry) were defined as abnormal. Regional cerebral glucose metabolism were compared between right and left cerebral hemispheres, and between the following subgroups: multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, and low-grade intraventricular hemorrhage.
In the individual analysis, 21 (58.3%) of 36 VLBW infants exhibited asymmetric cerebral glucose metabolism. Fifteen infants (41.7%) exhibited right > left asymmetry, while six (16.7%) exhibited left > right asymmetry. In the regional analysis, right > left asymmetry was more extensive than left > right asymmetry. The metabolic ratio in the right frontal, temporal, and occipital cortices and right thalamus were significantly higher than those in the corresponding left regions. In the subgroup analyses, the cerebral glucose metabolism in infants with multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, or low-grade intraventricular hemorrhage were significantly lower than those in infants without these.
VLBW infants without structural abnormalities have asymmetry of cerebral glucose metabolism. Decreased cerebral glucose metabolism are noted in infants with neurodevelopmental risk factors. F-18 FDG PET could show microstructural abnormalities not detected by MRI in VLBW infants. |
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In the individual analysis, 21 (58.3%) of 36 VLBW infants exhibited asymmetric cerebral glucose metabolism. Fifteen infants (41.7%) exhibited right > left asymmetry, while six (16.7%) exhibited left > right asymmetry. In the regional analysis, right > left asymmetry was more extensive than left > right asymmetry. The metabolic ratio in the right frontal, temporal, and occipital cortices and right thalamus were significantly higher than those in the corresponding left regions. In the subgroup analyses, the cerebral glucose metabolism in infants with multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, or low-grade intraventricular hemorrhage were significantly lower than those in infants without these.
VLBW infants without structural abnormalities have asymmetry of cerebral glucose metabolism. Decreased cerebral glucose metabolism are noted in infants with neurodevelopmental risk factors. F-18 FDG PET could show microstructural abnormalities not detected by MRI in VLBW infants.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0186976</identifier><identifier>PMID: 29095842</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Age ; Asymmetry ; Automation ; Biology and Life Sciences ; Birth weight ; Births ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Brain injury ; Care and treatment ; Cerebral hemispheres ; Cerebral palsy ; Diagnosis ; Drug dosages ; Dysplasia ; Female ; Fluorine ; Fluorodeoxyglucose F18 - metabolism ; Glucose ; Glucose - metabolism ; Head injuries ; Health aspects ; Hemispheric laterality ; Hemorrhage ; Humans ; Infant, Newborn ; Infant, Very Low Birth Weight ; Infants ; Low birth weight ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medicine and Health Sciences ; Metabolism ; Neurodevelopment ; NMR ; Nuclear magnetic resonance ; Nuclear medicine ; Pediatrics ; People and Places ; Positron emission ; Positron emission tomography ; Quality ; Radioisotopes ; Regional analysis ; Regional planning ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Rupture ; Studies ; Subgroups ; Thalamus ; Tomography ; Tomography, X-Ray Computed ; Traumatic brain injury</subject><ispartof>PloS one, 2017-11, Vol.12 (11), p.e0186976-e0186976</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Park et al 2017 Park et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8453855be7953ea3c6ce768a0c0a64945ead72022ddfffc0eb4a85b5550dc7a3</citedby><cites>FETCH-LOGICAL-c692t-8453855be7953ea3c6ce768a0c0a64945ead72022ddfffc0eb4a85b5550dc7a3</cites><orcidid>0000-0002-6707-3904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667759/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667759/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29095842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jae Hyun</creatorcontrib><creatorcontrib>Kim, Chun Soo</creatorcontrib><creatorcontrib>Won, Kyoung Sook</creatorcontrib><creatorcontrib>Oh, Jungsu S</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Kim, Hae Won</creatorcontrib><title>Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more than 10% (right > left asymmetry) or less than -10% (left > right asymmetry) were defined as abnormal. Regional cerebral glucose metabolism were compared between right and left cerebral hemispheres, and between the following subgroups: multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, and low-grade intraventricular hemorrhage.
In the individual analysis, 21 (58.3%) of 36 VLBW infants exhibited asymmetric cerebral glucose metabolism. Fifteen infants (41.7%) exhibited right > left asymmetry, while six (16.7%) exhibited left > right asymmetry. In the regional analysis, right > left asymmetry was more extensive than left > right asymmetry. The metabolic ratio in the right frontal, temporal, and occipital cortices and right thalamus were significantly higher than those in the corresponding left regions. In the subgroup analyses, the cerebral glucose metabolism in infants with multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, or low-grade intraventricular hemorrhage were significantly lower than those in infants without these.
VLBW infants without structural abnormalities have asymmetry of cerebral glucose metabolism. Decreased cerebral glucose metabolism are noted in infants with neurodevelopmental risk factors. F-18 FDG PET could show microstructural abnormalities not detected by MRI in VLBW infants.</description><subject>Abnormalities</subject><subject>Age</subject><subject>Asymmetry</subject><subject>Automation</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Births</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain injury</subject><subject>Care and treatment</subject><subject>Cerebral hemispheres</subject><subject>Cerebral palsy</subject><subject>Diagnosis</subject><subject>Drug dosages</subject><subject>Dysplasia</subject><subject>Female</subject><subject>Fluorine</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Head injuries</subject><subject>Health aspects</subject><subject>Hemispheric laterality</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants</subject><subject>Low birth weight</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Neurodevelopment</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear medicine</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Quality</subject><subject>Radioisotopes</subject><subject>Regional analysis</subject><subject>Regional planning</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Rupture</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Thalamus</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Traumatic brain 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of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities</title><author>Park, Jae Hyun ; Kim, Chun Soo ; Won, Kyoung Sook ; Oh, Jungsu S ; Kim, Jae Seung ; Kim, Hae Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8453855be7953ea3c6ce768a0c0a64945ead72022ddfffc0eb4a85b5550dc7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abnormalities</topic><topic>Age</topic><topic>Asymmetry</topic><topic>Automation</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Births</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain injury</topic><topic>Care and treatment</topic><topic>Cerebral hemispheres</topic><topic>Cerebral palsy</topic><topic>Diagnosis</topic><topic>Drug dosages</topic><topic>Dysplasia</topic><topic>Female</topic><topic>Fluorine</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Head injuries</topic><topic>Health aspects</topic><topic>Hemispheric laterality</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants</topic><topic>Low birth weight</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Neurodevelopment</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear medicine</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Quality</topic><topic>Radioisotopes</topic><topic>Regional analysis</topic><topic>Regional 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One</addtitle><date>2017-11-02</date><risdate>2017</risdate><volume>12</volume><issue>11</issue><spage>e0186976</spage><epage>e0186976</epage><pages>e0186976-e0186976</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more than 10% (right > left asymmetry) or less than -10% (left > right asymmetry) were defined as abnormal. Regional cerebral glucose metabolism were compared between right and left cerebral hemispheres, and between the following subgroups: multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, and low-grade intraventricular hemorrhage.
In the individual analysis, 21 (58.3%) of 36 VLBW infants exhibited asymmetric cerebral glucose metabolism. Fifteen infants (41.7%) exhibited right > left asymmetry, while six (16.7%) exhibited left > right asymmetry. In the regional analysis, right > left asymmetry was more extensive than left > right asymmetry. The metabolic ratio in the right frontal, temporal, and occipital cortices and right thalamus were significantly higher than those in the corresponding left regions. In the subgroup analyses, the cerebral glucose metabolism in infants with multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, or low-grade intraventricular hemorrhage were significantly lower than those in infants without these.
VLBW infants without structural abnormalities have asymmetry of cerebral glucose metabolism. Decreased cerebral glucose metabolism are noted in infants with neurodevelopmental risk factors. F-18 FDG PET could show microstructural abnormalities not detected by MRI in VLBW infants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29095842</pmid><doi>10.1371/journal.pone.0186976</doi><tpages>e0186976</tpages><orcidid>https://orcid.org/0000-0002-6707-3904</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-11, Vol.12 (11), p.e0186976-e0186976 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Age Asymmetry Automation Biology and Life Sciences Birth weight Births Brain Brain - diagnostic imaging Brain - metabolism Brain injury Care and treatment Cerebral hemispheres Cerebral palsy Diagnosis Drug dosages Dysplasia Female Fluorine Fluorodeoxyglucose F18 - metabolism Glucose Glucose - metabolism Head injuries Health aspects Hemispheric laterality Hemorrhage Humans Infant, Newborn Infant, Very Low Birth Weight Infants Low birth weight Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medicine and Health Sciences Metabolism Neurodevelopment NMR Nuclear magnetic resonance Nuclear medicine Pediatrics People and Places Positron emission Positron emission tomography Quality Radioisotopes Regional analysis Regional planning Research and Analysis Methods Risk analysis Risk factors Rupture Studies Subgroups Thalamus Tomography Tomography, X-Ray Computed Traumatic brain injury |
| title | Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A05%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Asymmetry%20of%20cerebral%20glucose%20metabolism%20in%20very%20low-birth-weight%20infants%20without%20structural%20abnormalities&rft.jtitle=PloS%20one&rft.au=Park,%20Jae%20Hyun&rft.date=2017-11-02&rft.volume=12&rft.issue=11&rft.spage=e0186976&rft.epage=e0186976&rft.pages=e0186976-e0186976&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0186976&rft_dat=%3Cgale_plos_%3EA512896155%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1959206076&rft_id=info:pmid/29095842&rft_galeid=A512896155&rft_doaj_id=oai_doaj_org_article_764683a1a8ec4c0cb29fbfc55c54b961&rfr_iscdi=true |