Downregulation of TAP1 and TAP2 in early stage breast cancer

TAP1-TAP2 heterodimeric complexes are recognized as the transporter associated with antigen processing of major histocompatibility complex class I peptides for recognition by tumor-specific cytotoxic T lymphocytes. In this study, we investigated the immunohistochemical expression of TAP1 and TAP2 in...

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Veröffentlicht in:	PloS one 2017-11, Vol.12 (11), p.e0187323-e0187323
Hauptverfasser:	Henle, Andrea M, Nassar, Aziza, Puglisi-Knutson, Danell, Youssef, Bahaaeldin, Knutson, Keith L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigen presentation Antigen processing ATP Binding Cassette Transporter, Subfamily B, Member 2 - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 3 - metabolism Biology and Life Sciences Breast cancer Breast Neoplasms - metabolism Cancer Care and treatment Cohort Studies Cytotoxicity Defects Diagnosis Down-Regulation Early Diagnosis ErbB-2 protein Estrogens Female Gene expression Gene mutation Histopathology Humans Immunohistochemistry Immunology Immunotherapy Lung cancer Lymphocytes Lymphocytes T Major histocompatibility complex Medicine and Health Sciences Melanoma Metastasis Middle Aged Mutation Patients Peptides Progesterone Proteins Skin cancer T cells TAP protein Tumor necrosis factor Tumors Viral infections
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