Real world data on young patients with high-risk diffuse large B-cell lymphoma treated with R-CHOP or R-CHOEP - MYC, BCL2 and BCL6 as prognostic biomarkers

Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Whether this ap...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0186983-e0186983
Hauptverfasser:	Pedersen, Mette Ølgod, Gang, Anne Ortved, Brown, Peter, Pedersen, Michael, Knudsen, Helle, Nielsen, Signe Ledou, Poulsen, Tim, Wirenfeldt Klausen, Tobias, Høgdall, Estrid, Nørgaard, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Monoclonal, Murine-Derived - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-cell lymphoma Bcl-6 protein Biology and Life Sciences Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Care and treatment Cell survival Chemotherapy Cyclophosphamide - administration & dosage Doxorubicin - administration & dosage Etoposide Etoposide - administration & dosage Female Fluorescence Fluorescence in situ hybridization Gene expression Genetic aspects Hematology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Kaplan-Meier Estimate Leukemia Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - metabolism Lymphomas Male Medical prognosis Medicine and Health Sciences Middle Aged Myc protein Neoplasms Pathology Patients People and Places Prednisone - administration & dosage Prognosis Protein expression Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Research and Analysis Methods Retrospective Studies Risk Risk Factors Studies Survival Translocation Vincristine - administration & dosage Young Adult
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