Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were performed in 25 week-old male diet-induced (60% kC...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0186586-e0186586
Hauptverfasser:	More, Vijay R, Lao, Julie, McLaren, David G, Cumiskey, Anne-Marie, Murphy, Beth Ann, Chen, Ying, Previs, Stephen, Stout, Steven, Patel, Rajesh, Satapati, Santhosh, Li, Wenyu, Kowalik, Edward, Szeto, Daphne, Nawrocki, Andrea, Pocai, Alessandro, Wang, Liangsu, Carrington, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic agents Apolipoproteins Biology Biology and Life Sciences Cardiovascular disease Cholesterol Cholesterol - blood Complications and side effects Deuterium Diabetes Diet Dosage and administration Esterification Fatty acids Genetic aspects Glucagon Glucagon - agonists Glucagon - physiology Glucagon-Like Peptide Receptors - agonists Glucagon-Like Peptide Receptors - physiology Homeostasis Hyperglycemia Infusion Insulin LDLR protein Lipid Metabolism Lipids Lipogenesis Lipoprotein (low density) receptors Lipoproteins (low density) Lipoproteins (very low density) Liver Low density lipoprotein Male Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Oxidation Palmitic acid Peptides Pharmacology Physical Sciences Physiological aspects Plasma Plasmas (physics) Rodents Secretion Signaling Synthesis Triglycerides - blood Weight control
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