Association between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study
To examine the association between a history of periodontitis (PD) and incident systemic lupus erythematosus (SLE). We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly sel...
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| creator | Wu, Yi-Da Lin, Ching-Heng Chao, Wen-Cheng Liao, Tsai-Ling Chen, Der-Yuan Chen, Hsin-Hua |
| description | To examine the association between a history of periodontitis (PD) and incident systemic lupus erythematosus (SLE).
We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly selecting 72,040 non-SLE patients matched (1:10) for age, gender, and first diagnosis date (index date) as the control group. The correlation between PD and SLE risk was estimated using conditional logistic regression analysis, after making adjustments for confounders (including a history of diabetes and number of non-PD related dental visits before the index date). To evaluate the effects of PD severity and the lag time which occurred since the last PD visit on SLE development, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for subgroups of patients with PD according to their number of visits, cumulative cost and also the time gaps between their last PD-related visit and the index date.
A statistically significant association between a history of PD and newly diagnosed SLE was observed (OR, 1.21; 95% CI, 1.14-1.28; p-value, |
| doi_str_mv | 10.1371/journal.pone.0187075 |
| format | Article |
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We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly selecting 72,040 non-SLE patients matched (1:10) for age, gender, and first diagnosis date (index date) as the control group. The correlation between PD and SLE risk was estimated using conditional logistic regression analysis, after making adjustments for confounders (including a history of diabetes and number of non-PD related dental visits before the index date). To evaluate the effects of PD severity and the lag time which occurred since the last PD visit on SLE development, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for subgroups of patients with PD according to their number of visits, cumulative cost and also the time gaps between their last PD-related visit and the index date.
A statistically significant association between a history of PD and newly diagnosed SLE was observed (OR, 1.21; 95% CI, 1.14-1.28; p-value, <0.001). The association was both dose- and time-dependent and was found to be strongest when the interval between the last PD-related visit and the index date was less than three months (OR, 1.83; 95% CI, 1.61-2.09; p-value, <0.001). The association between PD exposure and SLE risk was consistently significant among subgroups stratified based on age, gender, or DM status.
The results of this nationwide, population-based, case-control study suggest that there is a significant association between a history of PD and incident SLE in Taiwan. This weak association is limited to lack of information on individual smoking status in the database.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0187075</identifier><identifier>PMID: 29059229</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ambulatory care ; Autoimmune diseases ; Bacterial infections ; Biology and Life Sciences ; Case-Control Studies ; Chronic conditions ; Complications and side effects ; Confidence intervals ; Confounding Factors (Epidemiology) ; Development and progression ; Diabetes ; Diabetes mellitus ; Disease ; Female ; Glycoproteins ; Gum disease ; Hospitals ; Humans ; Immunoglobulins ; Immunology ; Infections ; Internal medicine ; Lag time ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Male ; Medical research ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Patients ; People and Places ; Periodontitis ; Periodontitis - complications ; Physical Sciences ; Population ; Population studies ; Population-based studies ; Prognosis ; Regression analysis ; Research and Analysis Methods ; Rheumatoid arthritis ; Rheumatology ; Risk ; Risk Factors ; Smoking ; Statistical analysis ; Studies ; Subgroups ; Systemic lupus erythematosus ; Taiwan - epidemiology</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0187075-e0187075</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Wu et al 2017 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-adfeee68fff4d88dfce93600a595a0c0369ab5f1edcde7a6bf1b2ed855bc841c3</citedby><cites>FETCH-LOGICAL-c758t-adfeee68fff4d88dfce93600a595a0c0369ab5f1edcde7a6bf1b2ed855bc841c3</cites><orcidid>0000-0002-7304-4587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653351/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653351/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79355,79356</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29059229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kuwana, Masataka</contributor><creatorcontrib>Wu, Yi-Da</creatorcontrib><creatorcontrib>Lin, Ching-Heng</creatorcontrib><creatorcontrib>Chao, Wen-Cheng</creatorcontrib><creatorcontrib>Liao, Tsai-Ling</creatorcontrib><creatorcontrib>Chen, Der-Yuan</creatorcontrib><creatorcontrib>Chen, Hsin-Hua</creatorcontrib><title>Association between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To examine the association between a history of periodontitis (PD) and incident systemic lupus erythematosus (SLE).
We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly selecting 72,040 non-SLE patients matched (1:10) for age, gender, and first diagnosis date (index date) as the control group. The correlation between PD and SLE risk was estimated using conditional logistic regression analysis, after making adjustments for confounders (including a history of diabetes and number of non-PD related dental visits before the index date). To evaluate the effects of PD severity and the lag time which occurred since the last PD visit on SLE development, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for subgroups of patients with PD according to their number of visits, cumulative cost and also the time gaps between their last PD-related visit and the index date.
A statistically significant association between a history of PD and newly diagnosed SLE was observed (OR, 1.21; 95% CI, 1.14-1.28; p-value, <0.001). The association was both dose- and time-dependent and was found to be strongest when the interval between the last PD-related visit and the index date was less than three months (OR, 1.83; 95% CI, 1.61-2.09; p-value, <0.001). The association between PD exposure and SLE risk was consistently significant among subgroups stratified based on age, gender, or DM status.
The results of this nationwide, population-based, case-control study suggest that there is a significant association between a history of PD and incident SLE in Taiwan. This weak association is limited to lack of information on individual smoking status in the database.</description><subject>Ambulatory care</subject><subject>Autoimmune diseases</subject><subject>Bacterial infections</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Chronic conditions</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease</subject><subject>Female</subject><subject>Glycoproteins</subject><subject>Gum disease</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Infections</subject><subject>Internal medicine</subject><subject>Lag time</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>People and Places</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Systemic lupus erythematosus</subject><subject>Taiwan - epidemiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21v0zAQxyMEYmPwDRBYQkIgrcWO48ThBVI18VBp0iQYvLUc-9y6pHFmO4x-FL4tTttNK9oLFEV-uN_9z3f2ZdlzgqeEVuTdyg2-k-20dx1MMeEVrtiD7JjUNJ-UOaYP78yPsichrDBmlJfl4-worzGr87w-zv7MQnDKymhdhxqI1wAdkmhpQ3R-g5xBPXjrtOuijTYg2WkUl4C8DT9Ha9iECGurUDv0Q0DgN8m6ltGFtLIdupT2Wnbv0Qx12xjXVsMp6l0_tNv1pJEB9ClSaZioFMW7FoU46M3T7JGRbYBn-_Ek-_7p4-XZl8n5xef52ex8oirG40RqAwAlN8YUmnNtFNS0xFiymkmsMC1r2TBDQCsNlSwbQ5ocNGesUbwgip5kL3e6feuC2Fc1CFKzospx-hMx3xHayZXovV1LvxFOWrHdcH4hpI9WtSA4rTnGpTIF5YUsMedNXlPKcc4Uk7lJWh_20YZmnc4EKWPZHogeWjq7FAv3S7CSUcpIEnizF_DuaoAQxdoGBW0rO3DD9twMl7TidUJf_YPen92eWsiUgO2MS3HVKCpmjBBclLwYtab3UOnT4-2nJ2hs2j9weHvgMN4t_I4LOYQg5t--_j978eOQfX2HXYJs4zK4dhgfUzgEix2ovAvBg7ktMsFi7KCbaoixg8S-g5Lbi7sXdOt00zL0L1DeGfo</recordid><startdate>20171023</startdate><enddate>20171023</enddate><creator>Wu, 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between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study</title><author>Wu, Yi-Da ; Lin, Ching-Heng ; Chao, Wen-Cheng ; Liao, Tsai-Ling ; Chen, Der-Yuan ; Chen, Hsin-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-adfeee68fff4d88dfce93600a595a0c0369ab5f1edcde7a6bf1b2ed855bc841c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Ambulatory care</topic><topic>Autoimmune diseases</topic><topic>Bacterial infections</topic><topic>Biology and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Chronic conditions</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes 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arthritis</topic><topic>Rheumatology</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Systemic lupus erythematosus</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yi-Da</creatorcontrib><creatorcontrib>Lin, Ching-Heng</creatorcontrib><creatorcontrib>Chao, Wen-Cheng</creatorcontrib><creatorcontrib>Liao, Tsai-Ling</creatorcontrib><creatorcontrib>Chen, Der-Yuan</creatorcontrib><creatorcontrib>Chen, Hsin-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central 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Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yi-Da</au><au>Lin, Ching-Heng</au><au>Chao, Wen-Cheng</au><au>Liao, Tsai-Ling</au><au>Chen, Der-Yuan</au><au>Chen, Hsin-Hua</au><au>Kuwana, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-23</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0187075</spage><epage>e0187075</epage><pages>e0187075-e0187075</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To examine the association between a history of periodontitis (PD) and incident systemic lupus erythematosus (SLE).
We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly selecting 72,040 non-SLE patients matched (1:10) for age, gender, and first diagnosis date (index date) as the control group. The correlation between PD and SLE risk was estimated using conditional logistic regression analysis, after making adjustments for confounders (including a history of diabetes and number of non-PD related dental visits before the index date). To evaluate the effects of PD severity and the lag time which occurred since the last PD visit on SLE development, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for subgroups of patients with PD according to their number of visits, cumulative cost and also the time gaps between their last PD-related visit and the index date.
A statistically significant association between a history of PD and newly diagnosed SLE was observed (OR, 1.21; 95% CI, 1.14-1.28; p-value, <0.001). The association was both dose- and time-dependent and was found to be strongest when the interval between the last PD-related visit and the index date was less than three months (OR, 1.83; 95% CI, 1.61-2.09; p-value, <0.001). The association between PD exposure and SLE risk was consistently significant among subgroups stratified based on age, gender, or DM status.
The results of this nationwide, population-based, case-control study suggest that there is a significant association between a history of PD and incident SLE in Taiwan. This weak association is limited to lack of information on individual smoking status in the database.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29059229</pmid><doi>10.1371/journal.pone.0187075</doi><tpages>e0187075</tpages><orcidid>https://orcid.org/0000-0002-7304-4587</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-10, Vol.12 (10), p.e0187075-e0187075 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1954720472 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Ambulatory care Autoimmune diseases Bacterial infections Biology and Life Sciences Case-Control Studies Chronic conditions Complications and side effects Confidence intervals Confounding Factors (Epidemiology) Development and progression Diabetes Diabetes mellitus Disease Female Glycoproteins Gum disease Hospitals Humans Immunoglobulins Immunology Infections Internal medicine Lag time Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - epidemiology Male Medical research Medicine Medicine and Health Sciences Middle Aged Patients People and Places Periodontitis Periodontitis - complications Physical Sciences Population Population studies Population-based studies Prognosis Regression analysis Research and Analysis Methods Rheumatoid arthritis Rheumatology Risk Risk Factors Smoking Statistical analysis Studies Subgroups Systemic lupus erythematosus Taiwan - epidemiology |
| title | Association between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T20%3A06%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20a%20history%20of%20periodontitis%20and%20the%20risk%20of%20systemic%20lupus%20erythematosus%20in%20Taiwan:%20A%20nationwide,%20population-based,%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Wu,%20Yi-Da&rft.date=2017-10-23&rft.volume=12&rft.issue=10&rft.spage=e0187075&rft.epage=e0187075&rft.pages=e0187075-e0187075&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0187075&rft_dat=%3Cgale_plos_%3EA511046849%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1954720472&rft_id=info:pmid/29059229&rft_galeid=A511046849&rft_doaj_id=oai_doaj_org_article_8398006cf4384a6088b29338025c5a2f&rfr_iscdi=true |