HIV dynamics linked to memory CD4+ T cell homeostasis

The dynamics of latent HIV is linked to infection and clearance of resting memory CD4+ T cells. Infection also resides within activated, non-dividing memory cells and can be impacted by antigen-driven and homeostatic proliferation despite suppressive antiretroviral therapy (ART). We investigated whe...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0186101-e0186101
Hauptverfasser:	Murray, John M, Zaunders, John, Emery, Sean, Cooper, David A, Hey-Nguyen, William J, Koelsch, Kersten K, Kelleher, Anthony D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology and Life Sciences CD4 antigen CD4 lymphocytes CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell proliferation Computer memory Computer simulation Decay Deoxyribonucleic acid Development and progression Diagnosis DNA Drug Administration Schedule Drug therapy Drugs Dynamics Genetic aspects Half-life Health aspects HIV HIV - physiology HIV infections HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Integrase Inhibitors - administration & dosage HIV Integrase Inhibitors - therapeutic use Homeostasis Human immunodeficiency virus Humans Immunologic Memory Immunological memory Infections Latent infection Lymphocytes Lymphocytes T Mathematical models Medicine and Health Sciences Memory cells Peripheral blood Physiological aspects Raltegravir Potassium - administration & dosage Raltegravir Potassium - therapeutic use Studies Viral Load Viremia Virions
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