Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies
A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squ...
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| description | A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients. We retrieved databases and screened eligible papers up to March 10, 2017 and then we extracted the essential data. The subgroup analyses were also performed based on the tumor site, region, and genotyping means. Crude odds ratios (OR) at 95% confidence intervals (CI) were chosen to describe the strength of the association. As a result, 6 publications were included in our study which involved 8 independent case-control studies. A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs. GG: OR = 1.13; 95%CI = 1.00-1.29; CC vs. GG: OR = 1.19; 95%CI = 1.03-1.38]. According to the subgroup analysis based on tumor site, the risk of cancer was significantly increased among laryngeal cancer (dominant model: OR = 1.76, 95%CI = 1.26~2.46, P = 0.001; homozygote model: OR = 1.83, 95%CI = 1.25~2.67, P = 0.002) and nasopharyngeal carcinoma (homozygote model: OR = 1.41, 95%CI = 1.05~1.90, P = 0.022). In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site. Further studies including a larger sample size will be necessary to clarify these results. |
| doi_str_mv | 10.1371/journal.pone.0186609 |
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Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients. We retrieved databases and screened eligible papers up to March 10, 2017 and then we extracted the essential data. The subgroup analyses were also performed based on the tumor site, region, and genotyping means. Crude odds ratios (OR) at 95% confidence intervals (CI) were chosen to describe the strength of the association. As a result, 6 publications were included in our study which involved 8 independent case-control studies. A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs. GG: OR = 1.13; 95%CI = 1.00-1.29; CC vs. GG: OR = 1.19; 95%CI = 1.03-1.38]. According to the subgroup analysis based on tumor site, the risk of cancer was significantly increased among laryngeal cancer (dominant model: OR = 1.76, 95%CI = 1.26~2.46, P = 0.001; homozygote model: OR = 1.83, 95%CI = 1.25~2.67, P = 0.002) and nasopharyngeal carcinoma (homozygote model: OR = 1.41, 95%CI = 1.05~1.90, P = 0.022). In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site. Further studies including a larger sample size will be necessary to clarify these results.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0186609</identifier><identifier>PMID: 29049342</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alleles ; Analysis ; Biology and life sciences ; Breast cancer ; Cancer ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; China ; Confidence intervals ; Data processing ; Epidemiology ; Ethnicity ; Gene expression ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotyping ; Head & neck cancer ; Head and neck cancer ; Head and Neck Neoplasms - genetics ; Health risks ; Human papillomavirus ; Humans ; Laryngeal cancer ; Medical ethics ; Medicine and Health Sciences ; Meta-analysis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Nasopharyngeal carcinoma ; Otolaryngology ; Patients ; People and Places ; Physical Sciences ; Physiological aspects ; Polymorphism ; Polymorphism, Genetic ; Research and Analysis Methods ; Ribonucleic acid ; Risk ; Risk factors ; RNA ; Science Policy ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; Studies ; Throat cancer ; Thyroid cancer</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0186609-e0186609</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Zhang et al 2017 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-43db8dbeba438a56df4d5f7fa8f3c6987a2df3f2a8c486d34c198595e85153cf3</citedby><cites>FETCH-LOGICAL-c692t-43db8dbeba438a56df4d5f7fa8f3c6987a2df3f2a8c486d34c198595e85153cf3</cites><orcidid>0000-0001-6686-9743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648221/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648221/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29049342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Silin</creatorcontrib><creatorcontrib>Hu, Fangling</creatorcontrib><creatorcontrib>Liang, Hongxing</creatorcontrib><creatorcontrib>Liu, Yuanzhou</creatorcontrib><creatorcontrib>Yang, Jianqiang</creatorcontrib><creatorcontrib>Zhou, Wensheng</creatorcontrib><title>Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients. We retrieved databases and screened eligible papers up to March 10, 2017 and then we extracted the essential data. The subgroup analyses were also performed based on the tumor site, region, and genotyping means. Crude odds ratios (OR) at 95% confidence intervals (CI) were chosen to describe the strength of the association. As a result, 6 publications were included in our study which involved 8 independent case-control studies. A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs. GG: OR = 1.13; 95%CI = 1.00-1.29; CC vs. GG: OR = 1.19; 95%CI = 1.03-1.38]. According to the subgroup analysis based on tumor site, the risk of cancer was significantly increased among laryngeal cancer (dominant model: OR = 1.76, 95%CI = 1.26~2.46, P = 0.001; homozygote model: OR = 1.83, 95%CI = 1.25~2.67, P = 0.002) and nasopharyngeal carcinoma (homozygote model: OR = 1.41, 95%CI = 1.05~1.90, P = 0.022). In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site. Further studies including a larger sample size will be necessary to clarify these results.</description><subject>Alleles</subject><subject>Analysis</subject><subject>Biology and life sciences</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Confidence intervals</subject><subject>Data processing</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotyping</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Health risks</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Medical ethics</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Nasopharyngeal carcinoma</subject><subject>Otolaryngology</subject><subject>Patients</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Research and Analysis Methods</subject><subject>Ribonucleic acid</subject><subject>Risk</subject><subject>Risk factors</subject><subject>RNA</subject><subject>Science Policy</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Studies</subject><subject>Throat cancer</subject><subject>Thyroid cancer</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG4yBLHjuNwgbSqOFSqqFQOt5bjw65LYqcZB9g34jFxutuqi3qBIiWR_c0_nn88WfYUFwtMavzmIkyjl91iCN4sCswZK5p72SFuSJmzsiD3b_0fZI8ALoqiIgl7mB2UTUEbQsvD7M8SICgnowsetSb-MsYjiXp3_nmZY8okGkK36cM4rB30SHqNYAJlhuha17m4QTGgtZH6assb9QPB5ST7MAFSpuuQkqNyPvQSOY-O184bMGhI-YyP8BYtUW-izGWqZAMOULCIpxgwuQo-jqFDECftDDzOHljZgXmy-x5l3z68_3r8KT89-3hyvDzNFWvKmFOiW65b00pKuKyYtlRXtraSW5IIXstSW2JLyRXlTBOqcMOrpjK8whVRlhxlz7e6QxdA7EwGgZuK4IoXjCXiZEvoIC_EMLpejhsRpBNXC2FcCTlGpzojal7Uqm3L9OI0HYdjrSptmWG1sdjWSevdLtvU9karZMoouz3R_R3v1mIVfoqKUV6WOAm82gmM4XIyEEXvYDZeepN6MJ-bFqxsOEnoi3_Qu6vbUSuZCnDehpRXzaJiWeGCYkLxTC3uoNKjTe9S54x1aX0v4PVewNxd8zuu5AQgTr6c_z979n2ffXmLTRexi2sI3TTfZ9gH6RZUYwAYjb0xGRdiHqhrN8Q8UGI3UCns2e0G3QRdTxD5C6KOHa4</recordid><startdate>20171019</startdate><enddate>20171019</enddate><creator>Zhang, Silin</creator><creator>Hu, Fangling</creator><creator>Liang, Hongxing</creator><creator>Liu, Yuanzhou</creator><creator>Yang, Jianqiang</creator><creator>Zhou, Wensheng</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6686-9743</orcidid></search><sort><creationdate>20171019</creationdate><title>Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies</title><author>Zhang, Silin ; Hu, Fangling ; Liang, Hongxing ; Liu, Yuanzhou ; Yang, Jianqiang ; Zhou, Wensheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-43db8dbeba438a56df4d5f7fa8f3c6987a2df3f2a8c486d34c198595e85153cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alleles</topic><topic>Analysis</topic><topic>Biology and life sciences</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Confidence intervals</topic><topic>Data processing</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotyping</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Health risks</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Laryngeal cancer</topic><topic>Medical ethics</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Nasopharyngeal carcinoma</topic><topic>Otolaryngology</topic><topic>Patients</topic><topic>People and Places</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Research and Analysis Methods</topic><topic>Ribonucleic acid</topic><topic>Risk</topic><topic>Risk factors</topic><topic>RNA</topic><topic>Science Policy</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Studies</topic><topic>Throat cancer</topic><topic>Thyroid cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Silin</creatorcontrib><creatorcontrib>Hu, Fangling</creatorcontrib><creatorcontrib>Liang, Hongxing</creatorcontrib><creatorcontrib>Liu, Yuanzhou</creatorcontrib><creatorcontrib>Yang, Jianqiang</creatorcontrib><creatorcontrib>Zhou, Wensheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Silin</au><au>Hu, Fangling</au><au>Liang, Hongxing</au><au>Liu, Yuanzhou</au><au>Yang, Jianqiang</au><au>Zhou, Wensheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-19</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0186609</spage><epage>e0186609</epage><pages>e0186609-e0186609</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients. We retrieved databases and screened eligible papers up to March 10, 2017 and then we extracted the essential data. The subgroup analyses were also performed based on the tumor site, region, and genotyping means. Crude odds ratios (OR) at 95% confidence intervals (CI) were chosen to describe the strength of the association. As a result, 6 publications were included in our study which involved 8 independent case-control studies. A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs. GG: OR = 1.13; 95%CI = 1.00-1.29; CC vs. GG: OR = 1.19; 95%CI = 1.03-1.38]. According to the subgroup analysis based on tumor site, the risk of cancer was significantly increased among laryngeal cancer (dominant model: OR = 1.76, 95%CI = 1.26~2.46, P = 0.001; homozygote model: OR = 1.83, 95%CI = 1.25~2.67, P = 0.002) and nasopharyngeal carcinoma (homozygote model: OR = 1.41, 95%CI = 1.05~1.90, P = 0.022). In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site. Further studies including a larger sample size will be necessary to clarify these results.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29049342</pmid><doi>10.1371/journal.pone.0186609</doi><tpages>e0186609</tpages><orcidid>https://orcid.org/0000-0001-6686-9743</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1953158066 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alleles Analysis Biology and life sciences Breast cancer Cancer Carcinoma, Squamous Cell - genetics Case-Control Studies China Confidence intervals Data processing Epidemiology Ethnicity Gene expression Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotyping Head & neck cancer Head and neck cancer Head and Neck Neoplasms - genetics Health risks Human papillomavirus Humans Laryngeal cancer Medical ethics Medicine and Health Sciences Meta-analysis MicroRNA MicroRNAs MicroRNAs - genetics miRNA Nasopharyngeal carcinoma Otolaryngology Patients People and Places Physical Sciences Physiological aspects Polymorphism Polymorphism, Genetic Research and Analysis Methods Ribonucleic acid Risk Risk factors RNA Science Policy Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Studies Throat cancer Thyroid cancer |
| title | Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A12%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20a%20miRNA-146a%20polymorphism%20and%20susceptibility%20to%20head%20and%20neck%20squamous%20cell%20carcinoma%20in%20Chinese%20patients:%20A%20meta-analysis%20of%208%20case-control%20studies&rft.jtitle=PloS%20one&rft.au=Zhang,%20Silin&rft.date=2017-10-19&rft.volume=12&rft.issue=10&rft.spage=e0186609&rft.epage=e0186609&rft.pages=e0186609-e0186609&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0186609&rft_dat=%3Cgale_plos_%3EA510413416%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1953158066&rft_id=info:pmid/29049342&rft_galeid=A510413416&rft_doaj_id=oai_doaj_org_article_7807cbb27cb848a581dc5df6e67ef1f7&rfr_iscdi=true |