The sequence preference of DNA methylation variation in mammalians
Methylation of cytosine at the 5 position of the pyrimidine ring is the most prevalent and significant epigenetic modifications in mammalian DNA. The CpG methylation level shows a bimodal distribution but the bimodality can be overestimated due to the heterogeneity of per-base depth. Here, we develo...
Gespeichert in:
| Veröffentlicht in: | PloS one 2017-10, Vol.12 (10), p.e0186559-e0186559 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0186559 |
|---|---|
| container_issue | 10 |
| container_start_page | e0186559 |
| container_title | PloS one |
| container_volume | 12 |
| creator | Zhang, Ling Gu, Chan Yang, Lijiang Tang, Fuchou Gao, Yi Qin |
| description | Methylation of cytosine at the 5 position of the pyrimidine ring is the most prevalent and significant epigenetic modifications in mammalian DNA. The CpG methylation level shows a bimodal distribution but the bimodality can be overestimated due to the heterogeneity of per-base depth. Here, we developed an algorithm to eliminate the effect of per-base depth inhomogeneity on the bimodality and obtained a random CpG methylation distribution. By quantifying the deviation of the observed methylation distribution and the random one using the information formula, we find that in tetranucleotides 5'-N5CGN3-3' (N5, N3 = A, C, G or T), GCGN3 and CCGN3 show less apparent deviation than ACGN3 and TCGN3, indicating that GCGN3 and CCGN3 are less variant in their level of methylation. The methylation variation of N5CGN3 are conserved among different cells, tissues and species, implying common features in the mechanisms of methylation and demethylation, presumably mediated by DNMTs and TETs in mammalians, respectively. Sequence dependence of DNA methylation variation also relates to gene regulatory and promotes the reexamination of the role of DNA sequence in fundamental biological processes. |
| doi_str_mv | 10.1371/journal.pone.0186559 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1952672188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A510237628</galeid><doaj_id>oai_doaj_org_article_94983ec2c6fd4f76a55d033c4453eede</doaj_id><sourcerecordid>A510237628</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-afad7d7bab5b147974925c5ef83a01cb50dda50c63880703ed7481b5c35469373</originalsourceid><addsrcrecordid>eNqNkl1v0zAUhiMEYqPwDxBEQkJw0WLHX_ENUhlfkyYmweDWcuyT1pUTlziZ2L_HbbOpQbtAvvCR_Zz3-By_WfYcowUmAr_bhKFrtV9sQwsLhEvOmHyQnWJJijkvEHl4FJ9kT2LcIMRIyfnj7KSQiDIqyWn24WoNeYTfA7QG8m0HNXT7MNT5x2_LvIF-feN170KbX-vOHSLX5o1uGu2dbuPT7FGtfYRn4z7Lfn7-dHX2dX5x-eX8bHkxN1wW_VzX2gorKl2xClMhBZUFMwzqkmiETcWQtZohw0lZIoEIWEFLXDFDGOWSCDLLXh50tz5ENbYfFZas4KLAZZmI8wNhg96obeca3d2ooJ3aH4RupXTXO-NBSSpLAqYwvLa0FlwzZhEhhlJGACwkrfdjtaFqwBpo-077iej0pnVrtQrXinHKy_TgWfZmFOhCGm_sVeOiAe91C2HYv5sUUsj0KbPs1T_o_d2N1EqnBlxbh1TX7ETVkmFUEMGLHbW4h0rLQuNM8krt0vkk4e0kITE9_OlXeohRnf_4_v_s5a8p-_qIXYP2_ToGP-wMFKcgPYCmCzEmB94NGSO1s_rtNNTO6mq0ekp7cfxBd0m33iZ_AW-D98M</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1952672188</pqid></control><display><type>article</type><title>The sequence preference of DNA methylation variation in mammalians</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zhang, Ling ; Gu, Chan ; Yang, Lijiang ; Tang, Fuchou ; Gao, Yi Qin</creator><contributor>Deng, Dajun</contributor><creatorcontrib>Zhang, Ling ; Gu, Chan ; Yang, Lijiang ; Tang, Fuchou ; Gao, Yi Qin ; Deng, Dajun</creatorcontrib><description>Methylation of cytosine at the 5 position of the pyrimidine ring is the most prevalent and significant epigenetic modifications in mammalian DNA. The CpG methylation level shows a bimodal distribution but the bimodality can be overestimated due to the heterogeneity of per-base depth. Here, we developed an algorithm to eliminate the effect of per-base depth inhomogeneity on the bimodality and obtained a random CpG methylation distribution. By quantifying the deviation of the observed methylation distribution and the random one using the information formula, we find that in tetranucleotides 5'-N5CGN3-3' (N5, N3 = A, C, G or T), GCGN3 and CCGN3 show less apparent deviation than ACGN3 and TCGN3, indicating that GCGN3 and CCGN3 are less variant in their level of methylation. The methylation variation of N5CGN3 are conserved among different cells, tissues and species, implying common features in the mechanisms of methylation and demethylation, presumably mediated by DNMTs and TETs in mammalians, respectively. Sequence dependence of DNA methylation variation also relates to gene regulatory and promotes the reexamination of the role of DNA sequence in fundamental biological processes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0186559</identifier><identifier>PMID: 29045493</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Base Sequence ; Biological activity ; Biology and life sciences ; Brain ; Brain - metabolism ; Cancer ; Chromosomes, Human, Pair 1 - genetics ; Computational chemistry ; Conserved Sequence - genetics ; CpG islands ; CpG Islands - genetics ; Cytosine ; Demethylation ; Deoxyribonucleic acid ; Deviation ; DNA ; DNA methylation ; DNA Methylation - genetics ; DNA sequencing ; Engineering ; Epigenetics ; Genetic aspects ; Genomes ; Humans ; Inhomogeneity ; Integrated software ; Life sciences ; Mammals ; Mammals - genetics ; Methylation ; Mice ; Nucleotide sequence ; Nucleotides - genetics ; Organ Specificity - genetics ; Oxidation ; Physical Sciences ; Physiological aspects ; Regulatory sequences ; Researchers ; Sequence Analysis, DNA ; Species Specificity ; Stem cells ; Studies ; Tissues ; Variation</subject><ispartof>PloS one, 2017-10, Vol.12 (10), p.e0186559-e0186559</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Zhang et al 2017 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-afad7d7bab5b147974925c5ef83a01cb50dda50c63880703ed7481b5c35469373</citedby><cites>FETCH-LOGICAL-c692t-afad7d7bab5b147974925c5ef83a01cb50dda50c63880703ed7481b5c35469373</cites><orcidid>0000-0002-4309-9376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646869/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646869/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29045493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Deng, Dajun</contributor><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Gu, Chan</creatorcontrib><creatorcontrib>Yang, Lijiang</creatorcontrib><creatorcontrib>Tang, Fuchou</creatorcontrib><creatorcontrib>Gao, Yi Qin</creatorcontrib><title>The sequence preference of DNA methylation variation in mammalians</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Methylation of cytosine at the 5 position of the pyrimidine ring is the most prevalent and significant epigenetic modifications in mammalian DNA. The CpG methylation level shows a bimodal distribution but the bimodality can be overestimated due to the heterogeneity of per-base depth. Here, we developed an algorithm to eliminate the effect of per-base depth inhomogeneity on the bimodality and obtained a random CpG methylation distribution. By quantifying the deviation of the observed methylation distribution and the random one using the information formula, we find that in tetranucleotides 5'-N5CGN3-3' (N5, N3 = A, C, G or T), GCGN3 and CCGN3 show less apparent deviation than ACGN3 and TCGN3, indicating that GCGN3 and CCGN3 are less variant in their level of methylation. The methylation variation of N5CGN3 are conserved among different cells, tissues and species, implying common features in the mechanisms of methylation and demethylation, presumably mediated by DNMTs and TETs in mammalians, respectively. Sequence dependence of DNA methylation variation also relates to gene regulatory and promotes the reexamination of the role of DNA sequence in fundamental biological processes.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological activity</subject><subject>Biology and life sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cancer</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Computational chemistry</subject><subject>Conserved Sequence - genetics</subject><subject>CpG islands</subject><subject>CpG Islands - genetics</subject><subject>Cytosine</subject><subject>Demethylation</subject><subject>Deoxyribonucleic acid</subject><subject>Deviation</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Methylation - genetics</subject><subject>DNA sequencing</subject><subject>Engineering</subject><subject>Epigenetics</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Humans</subject><subject>Inhomogeneity</subject><subject>Integrated software</subject><subject>Life sciences</subject><subject>Mammals</subject><subject>Mammals - genetics</subject><subject>Methylation</subject><subject>Mice</subject><subject>Nucleotide sequence</subject><subject>Nucleotides - genetics</subject><subject>Organ Specificity - genetics</subject><subject>Oxidation</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Regulatory sequences</subject><subject>Researchers</subject><subject>Sequence Analysis, DNA</subject><subject>Species Specificity</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Tissues</subject><subject>Variation</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYqPwDxBEQkJw0WLHX_ENUhlfkyYmweDWcuyT1pUTlziZ2L_HbbOpQbtAvvCR_Zz3-By_WfYcowUmAr_bhKFrtV9sQwsLhEvOmHyQnWJJijkvEHl4FJ9kT2LcIMRIyfnj7KSQiDIqyWn24WoNeYTfA7QG8m0HNXT7MNT5x2_LvIF-feN170KbX-vOHSLX5o1uGu2dbuPT7FGtfYRn4z7Lfn7-dHX2dX5x-eX8bHkxN1wW_VzX2gorKl2xClMhBZUFMwzqkmiETcWQtZohw0lZIoEIWEFLXDFDGOWSCDLLXh50tz5ENbYfFZas4KLAZZmI8wNhg96obeca3d2ooJ3aH4RupXTXO-NBSSpLAqYwvLa0FlwzZhEhhlJGACwkrfdjtaFqwBpo-077iej0pnVrtQrXinHKy_TgWfZmFOhCGm_sVeOiAe91C2HYv5sUUsj0KbPs1T_o_d2N1EqnBlxbh1TX7ETVkmFUEMGLHbW4h0rLQuNM8krt0vkk4e0kITE9_OlXeohRnf_4_v_s5a8p-_qIXYP2_ToGP-wMFKcgPYCmCzEmB94NGSO1s_rtNNTO6mq0ekp7cfxBd0m33iZ_AW-D98M</recordid><startdate>20171018</startdate><enddate>20171018</enddate><creator>Zhang, Ling</creator><creator>Gu, Chan</creator><creator>Yang, Lijiang</creator><creator>Tang, Fuchou</creator><creator>Gao, Yi Qin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4309-9376</orcidid></search><sort><creationdate>20171018</creationdate><title>The sequence preference of DNA methylation variation in mammalians</title><author>Zhang, Ling ; Gu, Chan ; Yang, Lijiang ; Tang, Fuchou ; Gao, Yi Qin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-afad7d7bab5b147974925c5ef83a01cb50dda50c63880703ed7481b5c35469373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological activity</topic><topic>Biology and life sciences</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Cancer</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Computational chemistry</topic><topic>Conserved Sequence - genetics</topic><topic>CpG islands</topic><topic>CpG Islands - genetics</topic><topic>Cytosine</topic><topic>Demethylation</topic><topic>Deoxyribonucleic acid</topic><topic>Deviation</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA Methylation - genetics</topic><topic>DNA sequencing</topic><topic>Engineering</topic><topic>Epigenetics</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Humans</topic><topic>Inhomogeneity</topic><topic>Integrated software</topic><topic>Life sciences</topic><topic>Mammals</topic><topic>Mammals - genetics</topic><topic>Methylation</topic><topic>Mice</topic><topic>Nucleotide sequence</topic><topic>Nucleotides - genetics</topic><topic>Organ Specificity - genetics</topic><topic>Oxidation</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Regulatory sequences</topic><topic>Researchers</topic><topic>Sequence Analysis, DNA</topic><topic>Species Specificity</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Tissues</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Gu, Chan</creatorcontrib><creatorcontrib>Yang, Lijiang</creatorcontrib><creatorcontrib>Tang, Fuchou</creatorcontrib><creatorcontrib>Gao, Yi Qin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ling</au><au>Gu, Chan</au><au>Yang, Lijiang</au><au>Tang, Fuchou</au><au>Gao, Yi Qin</au><au>Deng, Dajun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The sequence preference of DNA methylation variation in mammalians</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-10-18</date><risdate>2017</risdate><volume>12</volume><issue>10</issue><spage>e0186559</spage><epage>e0186559</epage><pages>e0186559-e0186559</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Methylation of cytosine at the 5 position of the pyrimidine ring is the most prevalent and significant epigenetic modifications in mammalian DNA. The CpG methylation level shows a bimodal distribution but the bimodality can be overestimated due to the heterogeneity of per-base depth. Here, we developed an algorithm to eliminate the effect of per-base depth inhomogeneity on the bimodality and obtained a random CpG methylation distribution. By quantifying the deviation of the observed methylation distribution and the random one using the information formula, we find that in tetranucleotides 5'-N5CGN3-3' (N5, N3 = A, C, G or T), GCGN3 and CCGN3 show less apparent deviation than ACGN3 and TCGN3, indicating that GCGN3 and CCGN3 are less variant in their level of methylation. The methylation variation of N5CGN3 are conserved among different cells, tissues and species, implying common features in the mechanisms of methylation and demethylation, presumably mediated by DNMTs and TETs in mammalians, respectively. Sequence dependence of DNA methylation variation also relates to gene regulatory and promotes the reexamination of the role of DNA sequence in fundamental biological processes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29045493</pmid><doi>10.1371/journal.pone.0186559</doi><tpages>e0186559</tpages><orcidid>https://orcid.org/0000-0002-4309-9376</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-10, Vol.12 (10), p.e0186559-e0186559 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1952672188 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Base Sequence Biological activity Biology and life sciences Brain Brain - metabolism Cancer Chromosomes, Human, Pair 1 - genetics Computational chemistry Conserved Sequence - genetics CpG islands CpG Islands - genetics Cytosine Demethylation Deoxyribonucleic acid Deviation DNA DNA methylation DNA Methylation - genetics DNA sequencing Engineering Epigenetics Genetic aspects Genomes Humans Inhomogeneity Integrated software Life sciences Mammals Mammals - genetics Methylation Mice Nucleotide sequence Nucleotides - genetics Organ Specificity - genetics Oxidation Physical Sciences Physiological aspects Regulatory sequences Researchers Sequence Analysis, DNA Species Specificity Stem cells Studies Tissues Variation |
| title | The sequence preference of DNA methylation variation in mammalians |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T15%3A59%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20sequence%20preference%20of%20DNA%20methylation%20variation%20in%20mammalians&rft.jtitle=PloS%20one&rft.au=Zhang,%20Ling&rft.date=2017-10-18&rft.volume=12&rft.issue=10&rft.spage=e0186559&rft.epage=e0186559&rft.pages=e0186559-e0186559&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0186559&rft_dat=%3Cgale_plos_%3EA510237628%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1952672188&rft_id=info:pmid/29045493&rft_galeid=A510237628&rft_doaj_id=oai_doaj_org_article_94983ec2c6fd4f76a55d033c4453eede&rfr_iscdi=true |