Cost-efficient vaccination protocols for network epidemiology
We investigate methods to vaccinate contact networks-i.e. removing nodes in such a way that disease spreading is hindered as much as possible-with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering o...
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| Veröffentlicht in: | PLoS computational biology 2017-09, Vol.13 (9), p.e1005696-e1005696 |
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| container_title | PLoS computational biology |
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| creator | Holme, Petter Litvak, Nelly |
| description | We investigate methods to vaccinate contact networks-i.e. removing nodes in such a way that disease spreading is hindered as much as possible-with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering of information about the network. Disregarding this, we argue, would lead to erroneous evaluation of vaccination protocols. We use the susceptible-infected-recovered model-the generic model for diseases making patients immune upon recovery-as our disease-spreading scenario, and analyze outbreaks on both empirical and model networks. For different relative costs, different protocols dominate. For high vaccination costs and low costs of gathering information, the so-called acquaintance vaccination is the most cost efficient. For other parameter values, protocols designed for query-efficient identification of the network's largest degrees are most efficient. |
| doi_str_mv | 10.1371/journal.pcbi.1005696 |
| format | Article |
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Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering of information about the network. Disregarding this, we argue, would lead to erroneous evaluation of vaccination protocols. We use the susceptible-infected-recovered model-the generic model for diseases making patients immune upon recovery-as our disease-spreading scenario, and analyze outbreaks on both empirical and model networks. For different relative costs, different protocols dominate. For high vaccination costs and low costs of gathering information, the so-called acquaintance vaccination is the most cost efficient. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Holme P, Litvak N (2017) Cost-efficient vaccination protocols for network epidemiology. PLoS Comput Biol13(9): e1005696. https://doi.org/10.1371/journal.pcbi.1005696</rights><rights>2017 Holme, Litvak 2017 Holme, Litvak</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Holme P, Litvak N (2017) Cost-efficient vaccination protocols for network epidemiology. 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| subjects | Biology and Life Sciences Communicable Disease Control - economics Communicable Disease Control - methods Communicable Diseases - transmission Computational Biology Computer and Information Sciences Computer Simulation Costs Costs and Cost Analysis Efficiency Empirical analysis Epidemics Epidemiology Hospitals Humans Immunization Infectious diseases Medicine and Health Sciences Outbreaks Protocol (computers) Research and Analysis Methods Social networks Spreading Studies Vaccination Vaccination - economics Vaccination - methods Vaccination - statistics & numerical data |
| title | Cost-efficient vaccination protocols for network epidemiology |
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