Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox"). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila gian...

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Veröffentlicht in:	PLoS biology 2017-09, Vol.15 (9), p.e2001655-e2001655
Hauptverfasser:	Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J, Madem, Sirisha Kudumala, Adcott, Jennifer, Kerr, Fiona, Wong, Chi Tung, Vincent, Alec, Godenschwege, Tanja, Boucrot, Emmanuel, Partridge, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - physiology Animals Biology and Life Sciences Cellular signal transduction Connexins - metabolism Data collection Drosophila Drosophila - physiology Electrical junctions Electrical transmission Escape Reaction - physiology Escape systems Evolution Female Flies Funding Gap junctions Gap Junctions - physiology Gene expression Guanosine Health aspects Health care Insects Insulin Insulin - metabolism Insulin-like growth factors Kinases Life span Male Medicine and Health Sciences Molecular biology Nervous system Neural circuitry Neurotransmission Proteins rab GTP-Binding Proteins - metabolism Research and Analysis Methods Scholarships & fellowships Shaking Somatomedins - metabolism Synaptic Transmission University colleges
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