HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2017-09, Vol.13 (9), p.e1006658-e1006658
Hauptverfasser:	Guo, Fang, Zhao, Qiong, Sheraz, Muhammad, Cheng, Junjun, Qi, Yonghe, Su, Qing, Cuconati, Andrea, Wei, Lai, Du, Yanming, Li, Wenhui, Chang, Jinhong, Guo, Ju-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Allosteric properties Amplification Antiviral agents Antiviral Agents - pharmacology Assembly Biology and Life Sciences Biosynthesis Blumberg, Baruch S Capsids Cell Line Circular DNA Core protein Cytoplasm Deoxyribonucleic acid Dismantling DNA DNA biosynthesis DNA polymerase DNA replication DNA, Circular - biosynthesis DNA, Circular - genetics DNA, Viral DNA-directed DNA polymerase DNA-Directed DNA Polymerase - metabolism DNA-directed RNA polymerase Dosage and administration Drug resistance Elongated structure Funding Genomes Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - physiology Hepatitis B, Chronic - virology Hepatocytes Hepatocytes - virology Hepatology Humans Infections Interferon Intracellular Kinetics Modulators Nucleocapsid - drug effects Nucleocapsid - genetics Nucleocapsids Offspring Physiological aspects Progeny Protein structure Proteins Real-Time Polymerase Chain Reaction Replication Research and analysis methods Ribonucleic acid RNA Rodents Uncoating Virions Virus Replication - drug effects Virus Replication - physiology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!