Development of rat female genital cortex and control of female puberty by sexual touch
Rat somatosensory cortex contains a large sexually monomorphic genital representation. Genital cortex undergoes an unusual 2-fold expansion during puberty. Here, we investigate genital cortex development and female rat sexual maturation. Ovariectomies and estradiol injections suggested sex hormones...
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| description | Rat somatosensory cortex contains a large sexually monomorphic genital representation. Genital cortex undergoes an unusual 2-fold expansion during puberty. Here, we investigate genital cortex development and female rat sexual maturation. Ovariectomies and estradiol injections suggested sex hormones cause the pubertal genital cortex expansion but not its maintenance at adult size. Genital cortex expanded by thalamic afferents invading surrounding dysgranular cortex. Genital touch was a dominant factor driving female sexual maturation. Raising female rats in contact with adult males promoted genital cortex expansion, whereas contact to adult females or nontactile (audio-visual-olfactory) male cues did not. Genital touch imposed by human experimenters powerfully advanced female genital cortex development and sexual maturation. Long-term blocking of genital cortex by tetrodotoxin in pubescent females housed with males prevented genital cortex expansion and decelerated vaginal opening. Sex hormones, sexual experience, and neural activity shape genital cortex, which contributes to the puberty promoting effects of sexual touch. |
| doi_str_mv | 10.1371/journal.pbio.2001283 |
| format | Article |
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Genital cortex undergoes an unusual 2-fold expansion during puberty. Here, we investigate genital cortex development and female rat sexual maturation. Ovariectomies and estradiol injections suggested sex hormones cause the pubertal genital cortex expansion but not its maintenance at adult size. Genital cortex expanded by thalamic afferents invading surrounding dysgranular cortex. Genital touch was a dominant factor driving female sexual maturation. Raising female rats in contact with adult males promoted genital cortex expansion, whereas contact to adult females or nontactile (audio-visual-olfactory) male cues did not. Genital touch imposed by human experimenters powerfully advanced female genital cortex development and sexual maturation. Long-term blocking of genital cortex by tetrodotoxin in pubescent females housed with males prevented genital cortex expansion and decelerated vaginal opening. Sex hormones, sexual experience, and neural activity shape genital cortex, which contributes to the puberty promoting effects of sexual touch.</description><identifier>ISSN: 1545-7885</identifier><identifier>ISSN: 1544-9173</identifier><identifier>EISSN: 1545-7885</identifier><identifier>DOI: 10.1371/journal.pbio.2001283</identifier><identifier>PMID: 28934203</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>17β-Estradiol ; Afferent Pathways - growth & development ; Animals ; Biology and Life Sciences ; Brain research ; Cortex (olfactory) ; Cortex (somatosensory) ; Cues ; Deceleration ; Expansion ; Female ; Females ; Gonadal Steroid Hormones - physiology ; Hormones ; Male ; Males ; Maturation ; Medicine and Health Sciences ; Neural circuitry ; Neurosciences ; Olfactory stimuli ; Ovariectomy ; Pheromones ; Physiological aspects ; Puberty ; Random Allocation ; Rats ; Rats, Wistar ; Rodents ; Sex ; Sex hormones ; Sexual Behavior, Animal - physiology ; Sexual Maturation ; Somatosensory cortex ; Somatosensory Cortex - growth & development ; Tetrodotoxin ; Thalamus ; Thalamus - growth & development ; Touch ; Uterus - growth & development ; Vagina ; Visual cortex ; Visual perception ; Visual stimuli</subject><ispartof>PLoS biology, 2017-09, Vol.15 (9), p.e2001283-e2001283</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Lenschow C, Sigl-Glöckner J, Brecht M (2017) Development of rat female genital cortex and control of female puberty by sexual touch. PLoS Biol15(9): e2001283. https://doi.org/10.1371/journal.pbio.2001283</rights><rights>2017 Lenschow et al 2017 Lenschow et al</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Lenschow C, Sigl-Glöckner J, Brecht M (2017) Development of rat female genital cortex and control of female puberty by sexual touch. PLoS Biol15(9): e2001283. https://doi.org/10.1371/journal.pbio.2001283</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c695t-c6b70ca4a50e4309f7870f45dd8f3002f4e97f0082f2cae5a71e5a177fee5c003</citedby><cites>FETCH-LOGICAL-c695t-c6b70ca4a50e4309f7870f45dd8f3002f4e97f0082f2cae5a71e5a177fee5c003</cites><orcidid>0000-0002-5387-0953</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608169/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608169/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28934203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kleinfeld, David</contributor><creatorcontrib>Lenschow, Constanze</creatorcontrib><creatorcontrib>Sigl-Glöckner, Johanna</creatorcontrib><creatorcontrib>Brecht, Michael</creatorcontrib><title>Development of rat female genital cortex and control of female puberty by sexual touch</title><title>PLoS biology</title><addtitle>PLoS Biol</addtitle><description>Rat somatosensory cortex contains a large sexually monomorphic genital representation. Genital cortex undergoes an unusual 2-fold expansion during puberty. Here, we investigate genital cortex development and female rat sexual maturation. Ovariectomies and estradiol injections suggested sex hormones cause the pubertal genital cortex expansion but not its maintenance at adult size. Genital cortex expanded by thalamic afferents invading surrounding dysgranular cortex. Genital touch was a dominant factor driving female sexual maturation. Raising female rats in contact with adult males promoted genital cortex expansion, whereas contact to adult females or nontactile (audio-visual-olfactory) male cues did not. Genital touch imposed by human experimenters powerfully advanced female genital cortex development and sexual maturation. Long-term blocking of genital cortex by tetrodotoxin in pubescent females housed with males prevented genital cortex expansion and decelerated vaginal opening. Sex hormones, sexual experience, and neural activity shape genital cortex, which contributes to the puberty promoting effects of sexual touch.</description><subject>17β-Estradiol</subject><subject>Afferent Pathways - growth & development</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Cortex (olfactory)</subject><subject>Cortex (somatosensory)</subject><subject>Cues</subject><subject>Deceleration</subject><subject>Expansion</subject><subject>Female</subject><subject>Females</subject><subject>Gonadal Steroid Hormones - physiology</subject><subject>Hormones</subject><subject>Male</subject><subject>Males</subject><subject>Maturation</subject><subject>Medicine and Health Sciences</subject><subject>Neural circuitry</subject><subject>Neurosciences</subject><subject>Olfactory stimuli</subject><subject>Ovariectomy</subject><subject>Pheromones</subject><subject>Physiological aspects</subject><subject>Puberty</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sex</subject><subject>Sex hormones</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Sexual Maturation</subject><subject>Somatosensory cortex</subject><subject>Somatosensory Cortex - growth & development</subject><subject>Tetrodotoxin</subject><subject>Thalamus</subject><subject>Thalamus - growth & development</subject><subject>Touch</subject><subject>Uterus - growth & development</subject><subject>Vagina</subject><subject>Visual cortex</subject><subject>Visual perception</subject><subject>Visual stimuli</subject><issn>1545-7885</issn><issn>1544-9173</issn><issn>1545-7885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVk11r2zAUhs3YWLtu_2Bsht1sF8n0Gck3g9J9BcoK--itkOWj1EG2Ukkuyb-fvLilGb3YEEhCfs6ro_f4FMVLjOaYCvx-7YfQazff1K2fE4QwkfRRcYw54zMhJX98b39UPItxjRAhFZFPiyMiK8oIosfF5Ue4Aec3HfSp9LYMOpUWOu2gXEHfJu1K40OCban7Jm_7FLwbwQnaDDWEtCvrXRlhO2Q8-cFcPS-eWO0ivJjWk-LX508_z77Ozi--LM9Oz2dmUfGU51ogo5nmCBhFlRVSIMt400hLc7qWQSUsQpJYYjRwLXCesBAWgBuE6Enxeq-7cT6qyZKocMUx40Qgmonlnmi8XqtNaDsddsrrVv058GGldEitcaAQ1LzJRnLLKyYk03VtG02oobYBQVjW-jDdNtQdNCZ7FrQ7ED380rdXauVvFF8giRdVFng7CQR_PUBMqmujAed0D34Y82ZkkUk85v3mL_Th103UKhdDtb31-V4ziqpTjgSVHLGRmj9A5dFA1-aagm3z-UHAu4OAse6wTSs9xKiWP77_B_vt39mLy0OW7VkTfIwB7J3PGKmxA24NUWMHqKkDctir-zW6C7r95elvNxYAdA</recordid><startdate>20170921</startdate><enddate>20170921</enddate><creator>Lenschow, Constanze</creator><creator>Sigl-Glöckner, Johanna</creator><creator>Brecht, Michael</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZG</scope><orcidid>https://orcid.org/0000-0002-5387-0953</orcidid></search><sort><creationdate>20170921</creationdate><title>Development of rat female genital cortex and control of female puberty by sexual touch</title><author>Lenschow, Constanze ; Sigl-Glöckner, Johanna ; Brecht, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c695t-c6b70ca4a50e4309f7870f45dd8f3002f4e97f0082f2cae5a71e5a177fee5c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>17β-Estradiol</topic><topic>Afferent Pathways - growth & development</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Brain research</topic><topic>Cortex (olfactory)</topic><topic>Cortex (somatosensory)</topic><topic>Cues</topic><topic>Deceleration</topic><topic>Expansion</topic><topic>Female</topic><topic>Females</topic><topic>Gonadal Steroid Hormones - physiology</topic><topic>Hormones</topic><topic>Male</topic><topic>Males</topic><topic>Maturation</topic><topic>Medicine and Health Sciences</topic><topic>Neural circuitry</topic><topic>Neurosciences</topic><topic>Olfactory stimuli</topic><topic>Ovariectomy</topic><topic>Pheromones</topic><topic>Physiological aspects</topic><topic>Puberty</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sex</topic><topic>Sex hormones</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Sexual Maturation</topic><topic>Somatosensory cortex</topic><topic>Somatosensory Cortex - growth & development</topic><topic>Tetrodotoxin</topic><topic>Thalamus</topic><topic>Thalamus - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Biology</collection><jtitle>PLoS biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lenschow, Constanze</au><au>Sigl-Glöckner, Johanna</au><au>Brecht, Michael</au><au>Kleinfeld, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of rat female genital cortex and control of female puberty by sexual touch</atitle><jtitle>PLoS biology</jtitle><addtitle>PLoS Biol</addtitle><date>2017-09-21</date><risdate>2017</risdate><volume>15</volume><issue>9</issue><spage>e2001283</spage><epage>e2001283</epage><pages>e2001283-e2001283</pages><issn>1545-7885</issn><issn>1544-9173</issn><eissn>1545-7885</eissn><abstract>Rat somatosensory cortex contains a large sexually monomorphic genital representation. Genital cortex undergoes an unusual 2-fold expansion during puberty. Here, we investigate genital cortex development and female rat sexual maturation. Ovariectomies and estradiol injections suggested sex hormones cause the pubertal genital cortex expansion but not its maintenance at adult size. Genital cortex expanded by thalamic afferents invading surrounding dysgranular cortex. Genital touch was a dominant factor driving female sexual maturation. Raising female rats in contact with adult males promoted genital cortex expansion, whereas contact to adult females or nontactile (audio-visual-olfactory) male cues did not. Genital touch imposed by human experimenters powerfully advanced female genital cortex development and sexual maturation. Long-term blocking of genital cortex by tetrodotoxin in pubescent females housed with males prevented genital cortex expansion and decelerated vaginal opening. Sex hormones, sexual experience, and neural activity shape genital cortex, which contributes to the puberty promoting effects of sexual touch.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28934203</pmid><doi>10.1371/journal.pbio.2001283</doi><orcidid>https://orcid.org/0000-0002-5387-0953</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 17β-Estradiol Afferent Pathways - growth & development Animals Biology and Life Sciences Brain research Cortex (olfactory) Cortex (somatosensory) Cues Deceleration Expansion Female Females Gonadal Steroid Hormones - physiology Hormones Male Males Maturation Medicine and Health Sciences Neural circuitry Neurosciences Olfactory stimuli Ovariectomy Pheromones Physiological aspects Puberty Random Allocation Rats Rats, Wistar Rodents Sex Sex hormones Sexual Behavior, Animal - physiology Sexual Maturation Somatosensory cortex Somatosensory Cortex - growth & development Tetrodotoxin Thalamus Thalamus - growth & development Touch Uterus - growth & development Vagina Visual cortex Visual perception Visual stimuli |
| title | Development of rat female genital cortex and control of female puberty by sexual touch |
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