Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution

The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a li...

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Veröffentlicht in:	PloS one 2007-03, Vol.2 (3), p.e299-e299
Hauptverfasser:	Han, Xue, Boyden, Edward S
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Activity patterns Anesthesiology and Pain Management/Anesthetic Mechanisms Animals Base Pairing Bioengineering Biophysics Biophysics/Experimental Biophysical Methods Biophysics/Membrane Proteins and Energy Transduction Biotechnology Brain Cardiac arrhythmia Cell Biology/Neuronal and Glial Cell Biology Cell Biology/Neuronal Signaling Mechanisms Chloride Codons Color Depolarization Disease DNA Primers Electrophysiology - methods Epilepsy Firing pattern Hippocampus - cytology Hippocampus - physiology Light Neural circuitry Neural networks Neurological Disorders Neurons Neurons - cytology Neurons - physiology Neurons - transplantation Neuroscience Neuroscience/Animal Cognition Neuroscience/Cognitive Neuroscience Neuroscience/Theoretical Neuroscience Neurosciences Pain Perturbation methods Pharmacology/Drug Development Photoinhibition Physiology Physiology/Neuronal Signaling Mechanisms Poisson Distribution Proteins Rats Rats, Sprague-Dawley Rhodopsin Sinuses Synchronization Temporal resolution Transfection Vision, Ocular - physiology
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