Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model

The role of astrocytes in Parkinson's disease is still not well understood. This work studied the astrocytic response to the dopaminergic denervation. Rats were injected in the lateral ventricles with 6-hydroxydopamine (25μg), inducing a dopaminergic denervation of the striatum not accompanied...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0185989-e0185989
Hauptverfasser:	Morales, Ingrid, Sanchez, Alberto, Rodriguez-Sabate, Clara, Rodriguez, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animal models Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Autophagy Biology and Life Sciences Biomedical research Brain research Cell death Debris Degeneration Denervation Detritus Disease Models, Animal Dopamine Dopamine - metabolism Dopamine receptors Dopamine transporter Dopaminergic mechanisms Genetic aspects Glial fibrillary acidic protein Hydroxylase Laboratories Lysosomes Male Medicine and Health Sciences Movement disorders Neostriatum Neostriatum - drug effects Neostriatum - pathology Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neurons Neurosciences Oxidopamine - pharmacology Parkinson disease Parkinson Disease - pathology Parkinson's disease Phagocytosis Phagosomes Phosphatidylserine Protein transport Proteins Rats Rats, Sprague-Dawley Rodents Spheroids Synuclein Tyrosine Tyrosine 3-monooxygenase Ventricle (lateral)
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