Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model
To explore the changes in the time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging in relation to variations in the contrast agent(CA) dosage in the Walker 256 murine breast tumor model, and to determine the appropriate parameters for the ev...
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| creator | Wu, Menglin Lu, Li Zhang, Qi Guo, Qi Zhao, Feixiang Li, Tongwei Zhang, Xuening |
| description | To explore the changes in the time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging in relation to variations in the contrast agent(CA) dosage in the Walker 256 murine breast tumor model, and to determine the appropriate parameters for the evaluation ofneoadjuvantchemotherapy(NAC)response.
Walker 256 breast tumor models were established in 21 rats, which were randomly divided into three groups of7rats each. Routine scanning and DCE-magnetic resonance imaging (MRI) of the rats were performed using a 7T MR scanner. The three groups of rats were administered different dosages of the CA0.2mmol/kg, 0.3mmol/kg, and 0.5mmol/kg, respectively; and the corresponding TICs the semi-quantitative parameters were calculated and compared among the three groups.
The TICs were not influenced by the CA dosage and presented a washout pattern in all of the tumors evaluated and weren't influenced by the CA dose. The values of the initial enhancement percentage(Efirst), initial enhancement velocity(Vfirst), maximum signal(Smax), maximum enhancement percentage(Emax), washout percentage(Ewash), and signal enhancement ratio(SER) showed statistically significant differences among the three groups (F = 16.952, p = 0.001; F = 69.483, p |
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| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1950593260</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b0917ac110564474905dfd50a7eaa4b5</doaj_id><sourcerecordid>1950593260</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-3619245d052bfd3a0b0b1b8bcb0f391a81a21e6a16fcf0d0cc9f706a6ce667433</originalsourceid><addsrcrecordid>eNptkt1u1DAQhSMEoqXwBggsccNNFjs_TsxFpTYtsFJXQFmurYk9WbxK7MVOKvECPDdeNq1axI1tjc_5PB6dJHnJ6ILlFXu3dZO30C92zuKCskJklXiUHDORZynPaP743vkoeRbCltIyrzl_mhxlXFBWV_w4-X2NPYzGbsiFCxiI60jj7OghjORsgzauejDWhBE9ajI6sl42BKwm33Aw6dcJ7GjGSLhB8gU8DBiFEWPJRXOZrq6X78k5hOiMFSCryRuL5Nzjnr-eBufJymnsnydPOugDvpj3k-T7h8t18ym9-vxx2ZxdparM-JjmnImsKDUts7bTOdCWtqytW9XSLhcMagYZQw6Md6qjmioluopy4Ao5r4o8P0leH7i73gU5jzBIJkpaxmFxGhXLg0I72MqdNwP4X9KBkX8Lzm8k-NGoHmVLBatAMUZLXhRVIWipO11SqBCgaMvIOp1fm9oBtcL9YPsH0Ic31vyQG3cji4pXrC4i4O0M8O7nhGGUgwkK-x4suin2HXWCxc5ZlL75R_r_3xUHlfIuBI_dXTOMyn2sbl1yHys5xyraXt3_yJ3pNkf5H6KZyvU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1950593260</pqid></control><display><type>article</type><title>Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Wu, Menglin ; Lu, Li ; Zhang, Qi ; Guo, Qi ; Zhao, Feixiang ; Li, Tongwei ; Zhang, Xuening</creator><contributor>Fan, Xiaobing</contributor><creatorcontrib>Wu, Menglin ; Lu, Li ; Zhang, Qi ; Guo, Qi ; Zhao, Feixiang ; Li, Tongwei ; Zhang, Xuening ; Fan, Xiaobing</creatorcontrib><description>To explore the changes in the time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging in relation to variations in the contrast agent(CA) dosage in the Walker 256 murine breast tumor model, and to determine the appropriate parameters for the evaluation ofneoadjuvantchemotherapy(NAC)response.
Walker 256 breast tumor models were established in 21 rats, which were randomly divided into three groups of7rats each. Routine scanning and DCE-magnetic resonance imaging (MRI) of the rats were performed using a 7T MR scanner. The three groups of rats were administered different dosages of the CA0.2mmol/kg, 0.3mmol/kg, and 0.5mmol/kg, respectively; and the corresponding TICs the semi-quantitative parameters were calculated and compared among the three groups.
The TICs were not influenced by the CA dosage and presented a washout pattern in all of the tumors evaluated and weren't influenced by the CA dose. The values of the initial enhancement percentage(Efirst), initial enhancement velocity(Vfirst), maximum signal(Smax), maximum enhancement percentage(Emax), washout percentage(Ewash), and signal enhancement ratio(SER) showed statistically significant differences among the three groups (F = 16.952, p = 0.001; F = 69.483, p<0.001; F = 54.838, p<0.001; F = 12.510, p = 0.003; F = 5.248, p = 0.031; F = 9.733, p = 0.006, respectively). However, the values of the time to peak(Tpeak), maximum enhancement velocity(Vmax), and washout velocity(Vwash)did not differ significantly among the three dosage groups (F = 0.065, p = 0.937; F = 1.505, p = 0.273; χ2 = 1.423, p = 0.319, respectively); the washout slope(Slopewash), too, was uninfluenced by the dosage(F = 1.654, p = 0.244).
The CA dosage didn't affect the TIC type, Tpeak, Vmax, Vwash or Slopewash. These dose-independent parameters as well as the TIC type might be more useful for monitoring the NAC response because they allow the comparisons of the DCE data obtained using different CA dosages.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149279</identifier><identifier>PMID: 26901876</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Animal models ; Animals ; Biology and Life Sciences ; Breast ; Breast cancer ; Breast Neoplasms - diagnosis ; Cancer therapies ; Cell Line, Tumor ; Chemotherapy ; Contrast agents ; Contrast Media - administration & dosage ; Disease Models, Animal ; Dosage ; Female ; Hospitals ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Mammary Neoplasms, Animal ; Mathematical models ; Medical diagnosis ; Medicine and Health Sciences ; Mice ; NMR ; Nuclear magnetic resonance ; Patients ; Rats ; Research and Analysis Methods ; Slopes ; Statistical analysis ; Studies ; Tumors ; Velocity</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149279-e0149279</ispartof><rights>2016 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Wu et al 2016 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-3619245d052bfd3a0b0b1b8bcb0f391a81a21e6a16fcf0d0cc9f706a6ce667433</citedby><cites>FETCH-LOGICAL-c526t-3619245d052bfd3a0b0b1b8bcb0f391a81a21e6a16fcf0d0cc9f706a6ce667433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767184/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767184/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26901876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fan, Xiaobing</contributor><creatorcontrib>Wu, Menglin</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Guo, Qi</creatorcontrib><creatorcontrib>Zhao, Feixiang</creatorcontrib><creatorcontrib>Li, Tongwei</creatorcontrib><creatorcontrib>Zhang, Xuening</creatorcontrib><title>Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To explore the changes in the time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging in relation to variations in the contrast agent(CA) dosage in the Walker 256 murine breast tumor model, and to determine the appropriate parameters for the evaluation ofneoadjuvantchemotherapy(NAC)response.
Walker 256 breast tumor models were established in 21 rats, which were randomly divided into three groups of7rats each. Routine scanning and DCE-magnetic resonance imaging (MRI) of the rats were performed using a 7T MR scanner. The three groups of rats were administered different dosages of the CA0.2mmol/kg, 0.3mmol/kg, and 0.5mmol/kg, respectively; and the corresponding TICs the semi-quantitative parameters were calculated and compared among the three groups.
The TICs were not influenced by the CA dosage and presented a washout pattern in all of the tumors evaluated and weren't influenced by the CA dose. The values of the initial enhancement percentage(Efirst), initial enhancement velocity(Vfirst), maximum signal(Smax), maximum enhancement percentage(Emax), washout percentage(Ewash), and signal enhancement ratio(SER) showed statistically significant differences among the three groups (F = 16.952, p = 0.001; F = 69.483, p<0.001; F = 54.838, p<0.001; F = 12.510, p = 0.003; F = 5.248, p = 0.031; F = 9.733, p = 0.006, respectively). However, the values of the time to peak(Tpeak), maximum enhancement velocity(Vmax), and washout velocity(Vwash)did not differ significantly among the three dosage groups (F = 0.065, p = 0.937; F = 1.505, p = 0.273; χ2 = 1.423, p = 0.319, respectively); the washout slope(Slopewash), too, was uninfluenced by the dosage(F = 1.654, p = 0.244).
The CA dosage didn't affect the TIC type, Tpeak, Vmax, Vwash or Slopewash. These dose-independent parameters as well as the TIC type might be more useful for monitoring the NAC response because they allow the comparisons of the DCE data obtained using different CA dosages.</description><subject>Accuracy</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Contrast agents</subject><subject>Contrast Media - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Dosage</subject><subject>Female</subject><subject>Hospitals</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Mammary Neoplasms, Animal</subject><subject>Mathematical models</subject><subject>Medical diagnosis</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Rats</subject><subject>Research and Analysis Methods</subject><subject>Slopes</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tumors</subject><subject>Velocity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkt1u1DAQhSMEoqXwBggsccNNFjs_TsxFpTYtsFJXQFmurYk9WbxK7MVOKvECPDdeNq1axI1tjc_5PB6dJHnJ6ILlFXu3dZO30C92zuKCskJklXiUHDORZynPaP743vkoeRbCltIyrzl_mhxlXFBWV_w4-X2NPYzGbsiFCxiI60jj7OghjORsgzauejDWhBE9ajI6sl42BKwm33Aw6dcJ7GjGSLhB8gU8DBiFEWPJRXOZrq6X78k5hOiMFSCryRuL5Nzjnr-eBufJymnsnydPOugDvpj3k-T7h8t18ym9-vxx2ZxdparM-JjmnImsKDUts7bTOdCWtqytW9XSLhcMagYZQw6Md6qjmioluopy4Ao5r4o8P0leH7i73gU5jzBIJkpaxmFxGhXLg0I72MqdNwP4X9KBkX8Lzm8k-NGoHmVLBatAMUZLXhRVIWipO11SqBCgaMvIOp1fm9oBtcL9YPsH0Ic31vyQG3cji4pXrC4i4O0M8O7nhGGUgwkK-x4suin2HXWCxc5ZlL75R_r_3xUHlfIuBI_dXTOMyn2sbl1yHys5xyraXt3_yJ3pNkf5H6KZyvU</recordid><startdate>20160222</startdate><enddate>20160222</enddate><creator>Wu, Menglin</creator><creator>Lu, Li</creator><creator>Zhang, Qi</creator><creator>Guo, Qi</creator><creator>Zhao, Feixiang</creator><creator>Li, Tongwei</creator><creator>Zhang, Xuening</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160222</creationdate><title>Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model</title><author>Wu, Menglin ; Lu, Li ; Zhang, Qi ; Guo, Qi ; Zhao, Feixiang ; Li, Tongwei ; Zhang, Xuening</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-3619245d052bfd3a0b0b1b8bcb0f391a81a21e6a16fcf0d0cc9f706a6ce667433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Accuracy</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Contrast agents</topic><topic>Contrast Media - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Dosage</topic><topic>Female</topic><topic>Hospitals</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Mammary Neoplasms, Animal</topic><topic>Mathematical models</topic><topic>Medical diagnosis</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Rats</topic><topic>Research and Analysis Methods</topic><topic>Slopes</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tumors</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Menglin</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Guo, Qi</creatorcontrib><creatorcontrib>Zhao, Feixiang</creatorcontrib><creatorcontrib>Li, Tongwei</creatorcontrib><creatorcontrib>Zhang, Xuening</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Menglin</au><au>Lu, Li</au><au>Zhang, Qi</au><au>Guo, Qi</au><au>Zhao, Feixiang</au><au>Li, Tongwei</au><au>Zhang, Xuening</au><au>Fan, Xiaobing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-22</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0149279</spage><epage>e0149279</epage><pages>e0149279-e0149279</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To explore the changes in the time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging in relation to variations in the contrast agent(CA) dosage in the Walker 256 murine breast tumor model, and to determine the appropriate parameters for the evaluation ofneoadjuvantchemotherapy(NAC)response.
Walker 256 breast tumor models were established in 21 rats, which were randomly divided into three groups of7rats each. Routine scanning and DCE-magnetic resonance imaging (MRI) of the rats were performed using a 7T MR scanner. The three groups of rats were administered different dosages of the CA0.2mmol/kg, 0.3mmol/kg, and 0.5mmol/kg, respectively; and the corresponding TICs the semi-quantitative parameters were calculated and compared among the three groups.
The TICs were not influenced by the CA dosage and presented a washout pattern in all of the tumors evaluated and weren't influenced by the CA dose. The values of the initial enhancement percentage(Efirst), initial enhancement velocity(Vfirst), maximum signal(Smax), maximum enhancement percentage(Emax), washout percentage(Ewash), and signal enhancement ratio(SER) showed statistically significant differences among the three groups (F = 16.952, p = 0.001; F = 69.483, p<0.001; F = 54.838, p<0.001; F = 12.510, p = 0.003; F = 5.248, p = 0.031; F = 9.733, p = 0.006, respectively). However, the values of the time to peak(Tpeak), maximum enhancement velocity(Vmax), and washout velocity(Vwash)did not differ significantly among the three dosage groups (F = 0.065, p = 0.937; F = 1.505, p = 0.273; χ2 = 1.423, p = 0.319, respectively); the washout slope(Slopewash), too, was uninfluenced by the dosage(F = 1.654, p = 0.244).
The CA dosage didn't affect the TIC type, Tpeak, Vmax, Vwash or Slopewash. These dose-independent parameters as well as the TIC type might be more useful for monitoring the NAC response because they allow the comparisons of the DCE data obtained using different CA dosages.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26901876</pmid><doi>10.1371/journal.pone.0149279</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Accuracy Animal models Animals Biology and Life Sciences Breast Breast cancer Breast Neoplasms - diagnosis Cancer therapies Cell Line, Tumor Chemotherapy Contrast agents Contrast Media - administration & dosage Disease Models, Animal Dosage Female Hospitals Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Mammary Neoplasms, Animal Mathematical models Medical diagnosis Medicine and Health Sciences Mice NMR Nuclear magnetic resonance Patients Rats Research and Analysis Methods Slopes Statistical analysis Studies Tumors Velocity |
| title | Relating Doses of Contrast Agent Administered to TIC and Semi-Quantitative Parameters on DCE-MRI: Based on a Murine Breast Tumor Model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A53%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relating%20Doses%20of%20Contrast%20Agent%20Administered%20to%20TIC%20and%20Semi-Quantitative%20Parameters%20on%20DCE-MRI:%20Based%20on%20a%20Murine%20Breast%20Tumor%20Model&rft.jtitle=PloS%20one&rft.au=Wu,%20Menglin&rft.date=2016-02-22&rft.volume=11&rft.issue=2&rft.spage=e0149279&rft.epage=e0149279&rft.pages=e0149279-e0149279&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0149279&rft_dat=%3Cproquest_plos_%3E1950593260%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1950593260&rft_id=info:pmid/26901876&rft_doaj_id=oai_doaj_org_article_b0917ac110564474905dfd50a7eaa4b5&rfr_iscdi=true |