Substance P Inhibits Hyperosmotic Stress-Induced Apoptosis in Corneal Epithelial Cells through the Mechanism of Akt Activation and Reactive Oxygen Species Scavenging via the Neurokinin-1 Receptor

Hyperosmolarity has been recognized as an important pathological factor in dry eye leading to ocular discomfort and damage. As one of the major neuropeptides of corneal innervation, substance P (SP) has been shown to possess anti-apoptotic effects in various cells. The aim of this study was to deter...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149865-e0149865
Hauptverfasser:	Yang, Lingling, Sui, Wenjie, Li, Yunqiu, Qi, Xia, Wang, Yao, Zhou, Qingjun, Gao, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Animals Apoptosis Apoptosis - drug effects Biology and Life Sciences Calcium (intracellular) Calcium (mitochondrial) Cell cycle Cell Line Cornea Cytochrome Diabetes Discomfort Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelium, Corneal - cytology Eye Genetic aspects Glucose Glutathione Innervation Kinases Laboratories Medicine and Health Sciences Membrane potential Mice Mitochondria Neurokinin Neurokinin NK1 receptors Neuropeptides Neurotransmitter Agents - pharmacology Osmotic pressure Osmotic Pressure - physiology Oxygen Physical Sciences Physiological aspects Proteins Proto-Oncogene Proteins c-akt Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Neurokinin-1 - metabolism Scavenging Stress Stresses Substance P Substance P - pharmacology
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